Abstract: The present disclosure provides recombinant adeno-associated virus (AAV) virions with altered capsid protein, where the recombinant AAV (rAAV) virions exhibit greater ability to cross barriers between intravitreal fluid and retinal cells, and thus greater infectivity of a retinal cell compared to wild-type AAV, and where the rAAV virions comprise a heterologous nucleic acid. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual.

Abstract: A cutting board and countertop are correspondingly constructed to enable the cutting board to be supported upon the countertop in multiple, varying height positions. The countertop preferably includes a main, substantially planar work surface provided with a frontal, upstanding lip, as well as at least one ledge provided at a position spaced across the work surface from the lip. The cutting board is generally constituted by substantially planar member having support elements provided on opposing, terminal side portions. In a first height position, the cutting board is arranged against both the lip and the ledge. In the second height position, the cutting board is inverted and positioned against the frontal lip and upon the ledge. In either position, the cutting board can readily slide along the countertop.

Abstract: An article support and transfer assembly includes a carrier frame, which is selectively shiftable between raised and lowered positions relative to a countertop work surface, and an article support tray which is mounted for sliding movement in opposing directions between a first extended position, wherein the article support tray projects, at least partially, over the work surface and, a second extended position, wherein the tray projects over a side edge portion of the countertop. The tray can be shifted between the first and second extended positions for loading and unloading thereof and arranged in an intermediate position wherein the tray can be lowered with the carrier frame into a base associated with the countertop.

Abstract: A combination shelf and serving tray assembly includes a tray provided with a platform removably supported upon a frame mounted within a refrigerator cabinet. The platform can be removed from the cabinet and used as a serving tray. A lower end of the platform is provided with various spaced projections in the form of legs or nubs, preferably having elastomeric tips. The frame includes fore-to-aft extending rails having slots formed therein into which the legs are adapted to extend. The length of the slots and the spacing between the legs permit sliding of the tray between extended and retracted positions within the refrigerator cabinet.

Abstract: A refrigerator cabinet includes a shell within which is defined at least one food compartment. For enhancing the access to the food storage compartment, the shell is provided with an open frontal zone which includes a frontal facing portion and a sideward facing portion. A door is hingedly connected adjacent one side of the cabinet, extends across the front of the cabinet and wraps around to an opposing side of the cabinet. In this fashion, a section of the door actually defines an extension of one side of the refrigerator cabinet such that, when the door is opened, enhanced access to within the refrigerator is provided.

Abstract: A workstation includes a countertop having a substantially planar upper surface below which extends an upstanding post that defines a substantially vertical axis. Further arranged under the countertop is a drawer that is interconnected to the upstanding post through a set of rail members. The set of rail members includes a first rail member fixed to the drawer and a second rail member which is slidably interconnected with the first rail member. The second rail member is further rotatably mounted to the upstanding post such that a drawer can slide between extended and retracted positions and also pivot about the vertical axis of the post. The drawer includes a handle which extends across both front and side wall portions of the drawer to enhance maneuvering of the drawer to a desired position.