Patents by Inventor John P. Fruehauf

John P. Fruehauf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition to destabilize abnormal methylation enzymes and use thereof
    Publication number: 20230064307
    Abstract: The present invention relates to the discoveries of the mechanism of wound healing, the relationship of wound healing to the evolution of cancer, and the use of such discoveries for the perfection of wound healing to avoid ugly scar and cancer evolution, and for the use to take out both cancer cells and cancer stem cells to accomplish a permanent cure of cancer.
    Type: Application
    Filed: August 28, 2021
    Publication date: March 2, 2023
    Inventors: Ming C. Liau, Christine Liau Craig, Linda Liau Baker, John P. Fruehauf
  • Methods for cancer prognosis and diagnosis
    Patent number: 7323300
    Abstract: The invention provides methods for prognosis, diagnosis, staging and disease progression in human cancer patients related to expression levels of a plurality of genes that are differentially expressed in chemotherapeutic drug resistant and drug sensitive tumor cells.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: January 29, 2008
    Assignee: Oncotech, Inc.
    Inventors: John P. Fruehauf, Eugene Mechetner
  • Methods for cancer prognosis and diagnosis relating to tumor vascular endothelial cells
    Patent number: 6998234
    Abstract: The invention provides methods for prognosis, diagnosis, staging and disease progression in human cancer patients related to expression levels of a plurality of genes that are differentially expressed in anti-angiogenic agent-sensitive and anti-angiogenic agent-resistant vascular endothelial cells as compared to baseline vascular endothelial cells.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: February 14, 2006
    Assignee: Oncotech, Inc.
    Inventors: John P. Fruehauf, Eugene Mechetner
  • Genes related to sensitivity and resistance to chemotherapeutic drug treatment
    Publication number: 20040214203
    Abstract: The invention provides methods for prognosis, diagnosis, staging and disease progression in human cancer patients related to expression levels of a plurality of genes that are differentially expressed in chemotherapeutic drug resistant and drug sensitive tumor cells.
    Type: Application
    Filed: December 12, 2003
    Publication date: October 28, 2004
    Applicant: Oncotech, Inc.
    Inventor: John P. Fruehauf
  • Methods for cancer prognosis and diagnosis relating to tumor vascular endothelial cells
    Publication number: 20030096261
    Abstract: The invention provides methods for prognosis, diagnosis, staging and disease progression in human cancer patients related to expression levels of a plurality of genes that are differentially expressed in anti-angiogenic agent-sensitive and anti-angiogenic agent-resistant vascular endothelial cells as compared to baseline vascular endothelial cells.
    Type: Application
    Filed: May 10, 2002
    Publication date: May 22, 2003
    Applicant: Oncotech Inc.
    Inventors: John P. Fruehauf, Eugene Mechemer
  • Methods for cancer prognosis and diagnosis
    Publication number: 20030096290
    Abstract: The invention provides methods for prognosis, diagnosis, staging and disease progression in human cancer patients related to expression levels of a plurality of genes that are differentially expressed in chemotherapeutic drug resistant and drug sensitive tumor cells.
    Type: Application
    Filed: November 15, 2002
    Publication date: May 22, 2003
    Applicant: Oncotech, Inc.
    Inventors: John P. Fruehauf, Eugene Mechetner
  • Radiation resistance assay for predicting treatment response and clinical outcome
    Patent number: 6261795
    Abstract: The present invention provides a novel method for assaying radiation resistance of cancer cells by isolating cancer cells, irradiating the cells, incubating the cells with a labeled marker indicative of cell proliferation, measuring the amount of labeled marker incorporated into the cells in order to determine the effect of radiation on the proliferation of cells, and then determining the relative resistance of the cells to radiation. Also provided are methods of assaying radiation resistance of cancer cells which are exposed to radiation and radio-sensitizing or chemotherapeutic agents.
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: July 17, 2001
    Assignee: Oncotech, Inc.
    Inventors: John P. Fruehauf, Ricardo J. Parker
  • Radiation resistance assay for predicting treatment response and clinical outcome
    Patent number: 6008007
    Abstract: The present invention provides a novel method for assaying radiation resistance of cancer cells by isolating cancer cells, irradiating the cells, incubating the cells with a labeled marker indicative of cell proliferation, measuring the amount of labeled marker incorporated into the cells in order to determine the effect of radiation on the proliferation of cells, and then determining the relative resistance of the cells to radiation. Also provided are methods of assaying radiation resistance of cancer cells which are exposed to radiation and radio-sensitzing or chemotherapeutic agents.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: December 28, 1999
    Assignee: Oncotech, Inc.
    Inventors: John P. Fruehauf, Ricardo J. Parker
  • 5.5 kD TNF degradation product
    Patent number: 5543139
    Abstract: A particular TNF degradation product is effective as a cytotoxin with respect both to TNF-sensitive and TNF-resistant tumor cells. Pharmaceutical compositions containing this degradation product are thus useful in treating tumors which are otherwise resistant to TNF. In addition, TNF resistance can be measured as a function of the expression of EGF receptors in tumor cells.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: August 6, 1996
    Inventor: John P. Fruehauf