Patents by Inventor John P. Leach

John P. Leach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DOMINANT ACTIVE YAP, A HIPPO EFFECTOR, INDUCES CHROMATIN ACCESSIBILITY AND CARDIOMYOCYTE RENEWAL
    Publication number: 20250073276
    Abstract: The present disclosure encompasses methods for generating cells or tissue from existing cells with one or more mutated variants of Yap. In specific embodiments, the disclosure regards treatment of existing cardiomyocytes with one or more mutated variants of Yap that causes them to divide and generate new cardiomyocytes. In specific cases, the mutated variant of Yap has serine-to-alanine substitutions at 1, 2, 3, 4, 5, 6, or more serines of Yap.
    Type: Application
    Filed: October 9, 2024
    Publication date: March 6, 2025
    Applicant: Baylor College of Medicine
    Inventors: Tanner Monroe, John P. Leach, James F. Martin
  • HIPPO AND DYSTROPHIN COMPLEX SIGNALING IN CARDIOMYOCYTE RENEWAL
    Publication number: 20240279661
    Abstract: Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed.
    Type: Application
    Filed: April 11, 2024
    Publication date: August 22, 2024
    Applicants: Baylor College of Medicine, Texas Heart Institute
    Inventors: James F. Martin, Yuka Morikawa, Todd Ryan Heallen, John P. Leach