Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy.

Abstract: Provided herein is technology relating to measuring and recording weather phenomena and particularly, but not exclusively, to apparatuses, methods, kits, and systems for measuring hydrometeor impacts, e.g., hail impacts.

Abstract: Provided herein is technology relating to measuring weather data and particularly, but not exclusively, to apparatuses, methods, and systems for sensing hydrometeors (e.g., rain) and measuring hydrometeor characteristics (e.g., volume, rate, size distribution, etc.).

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: Provided herein is technology relating to measuring weather data and particularly, but not exclusively, to apparatuses, methods, and systems for sensing hydrometeors (e.g., rain) and measuring hydrometeor characteristics (e.g., volume, rate, size distribution, etc.).

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: A method of treating polycystic kidney disease in a subject comprises administering to the subject an effective amount of a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy.

Abstract: A method of treating polycystic kidney disease in a subject comprises administering to the subject an effective amount of a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: A method of treating polycystic kidney disease in a subject comprises administering to the subject an effective amount of a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof.

Abstract: A method of treating polycystic kidney disease in a subject comprises administering to the subject an effective amount of a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof.

Abstract: A method of treating polycystic kidney disease in a subject comprises administering to the subject an effective amount of a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof.

Abstract: Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-? or TNF-?. Suitable conditions for treatment include multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes melitis and autoimmune inflammatory eye disease.

Abstract: A bracket for mounting components in a housing in which a first set of two legs extend from and substantially perpendicular to one surface of a plate and a second set of at least two legs extend from and perpendicular to the opposite surface of the plate. The bracket is connectable to the floor of the housing to support a first component at a predetermined height in said housing and is reversible to support a component of a greater height than the first component.

Abstract: Apparatus and method of anti-armor missile trajectory shaping for optimum rhead penetration of armor by a guided missile. The guidance system utilizes a terminal homing guidance unit in conjunction with a programmed control signal through the missile's autopilot to cause the missile to cruise at low altitudes and then dive onto the armor target. The terminal dive angle can be selected dependent upon the target's armor characteristics.

Abstract: In a missile system, a simple way to guide a missile in a predetermined tectory from launch to the impacting with a target for optimum warhead penetration of armor by a guided missile. Initially, the missile is guided in yaw by proportional navigation. Subsequently it is guided in pitch first by a pitch programmer until the missile reaches a predetermined gimbal angle between a line of sight of a seeker of the missile and a centerline of the missile, then in pitch by a pseudo-time-optimal closed loop controller to direct the missile pitch attitude at a predetermined rate toward a target until said missile reaches another predetermined gimbal angle, and finally by proportional navigation in pitch of the missile to the target.