Abstract: Described herein are novel compounds, compositions and methods for treatment of diseases including cancer using such compounds, compositions, and methods.

Abstract: Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, R4, R6, R7, R8 and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Abstract: Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X1, X2, X3, X4, Y, A, L1, L2, R1, R2, R5, m and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Abstract: Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof: wherein X1, X2, X3, X4, X5, A, L, R1, R2, R5, m and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Abstract: Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, R4, R6, R7, R8 and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Abstract: Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, R4, R6, R7, R8 and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Abstract: Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X1, X2, X3, X4, Y, A, L1, L2, R1, R2, R5, m and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Abstract: The subject invention is an improved lubrication system which supplies oil mist under pressure to externally inaccessible bearings and gears as well as supplying solid oil to externally accessible bearings, both from a single source. Both solid oil and oil mist are provided by use of conventional components. The system operates from power supplied by plant air and electricity. The subject invention employs a demister system, new to the art, which enhances the consolidation of oil particles within the gear housing, or other enclosures of moving parts to be lubricated. It reduces the amount of oil mist exhausted while retaining the benefits of a pressurized system to keep out contaminants and improves the health quality of the working environment.

Abstract: A control valve for selectively establishing connections between the spring applied parking brake in an air braked vehicle and either the parking brake air reservoir or the exhaust port of the control valve, and incorporating a lock which enables the operator to secure the control valve in the position in which the parking brakes are applied.