Abstract: Treatment compositions and methods for treating and/or preventing actinic keratosis comprising applying a chlorin treatment composition in a topical form to one or more actinic keratosis lesions. A treatment composition preferably comprises a copper chlorin, such as a sodium copper chlorophyllin complex, trisodium copper chlorin p6, disodium copper isochlorin e4, or trisodium copper chlorin e6 or a prodrug form of a copper chlorin such as diethyl copper chlorin e6. A treatment composition comprises around 0.002% to around 0.1% by weight of copper chlorin. Treatments disclosed herein may result in elimination of the actinic keratosis lesions.

Abstract: Compositions and methods for treating cancer, particularly leukemia, using a cytotoxic composition comprising monocytes activated by-glucan. The monocytes are preferably incubated with the ?-glucan and then processed to extract particles, such as microvesicles and exosomes from the treated monocytes to produce the cytotoxic composition. Preferably the cytotoxic composition comprises at least 50% exosomes having a size of 150 nm or less that are activated with ?-glucan. Zymosan is the preferred ?-glucan. The cytotoxic composition has an apoptosis effect. When a subject having cancer is treated according to preferred embodiments, the cytotoxic composition preferably induces a cytokine response in the subject's immune system. The combination of the cytotoxic composition and cytokine response are synergistic.

Abstract: Treatment compositions and methods for treating and/or preventing actinic keratosis comprising applying a chlorin treatment composition in a topical form to one or more actinic keratosis lesions. A treatment composition preferably comprises a copper chlorin, such as a sodium copper chlorophyllin complex, trisodium copper chlorin p6, disodium copper isochlorin e4, or trisodium copper chlorin e6. A treatment composition comprises around 0.002% to around 0.1% by weight of copper chlorin. Treatments disclosed herein may result in elimination of the actinic keratosis lesions.

Abstract: Compositions and methods for treating cancer, particularly leukemia, using a cytotoxic composition comprising monocytes activated by ?-glucan. The monocytes are preferably incubated with the ?-glucan and then processed to extract particles, such as microvesicles and exosomes from the treated monocytes to produce the cytotoxic composition. Preferably the cytotoxic composition comprises at least 50% exosomes having a size of 150 nm or less that are activated with ?-glucan. Zymosan is the preferred ?-glucan. The cytotoxic composition has an apoptosis effect. When a subject having cancer is treated according to preferred embodiments, the cytotoxic composition preferably induces a cytokine response in the subject's immune system. The combination of the cytotoxic composition and cytokine response are synergistic.

Abstract: Treatment compositions and methods for treating and/or preventing actinic keratosis comprising applying a chlorin treatment composition in a topical form to one or more actinic keratosis lesions. A treatment composition preferably comprises a copper chlorin, such as a sodium copper chlorophyllin complex, trisodium copper chlorin p6, disodium copper isochlorin e4, or trisodium copper chlorin e6. A treatment composition comprises around 0.002% to around 0.1% by weight of copper chlorin. Treatments disclosed herein may result in elimination of the actinic keratosis lesions.

Abstract: Treatment compositions and methods for treating and/or preventing human hair thinning or hair loss comprising applying a chlorin treatment composition to an area of skin/scalp in need of treatment. A treatment composition preferably comprises a copper chlorin, such as a sodium copper chlorophyllin complex, trisodium copper chlorin p6, disodium copper isochlorin e4, or trisodium copper chlorin e6. A treatment composition comprises around 0.02 to 0.1% by weight of a chlorin, preferably a copper chlorin. A density and/or diameter of hair in an area being treated may be increased by at least 5%, more preferably at least 15%. Immune privilege in an area being treated may also be restored as measured by change in certain immunoglobulin antibodies.

Abstract: Methods for increasing the density and diameter of human hair comprised of the step of applying to any skin area of the body and/or the scalp covered with hair, a topical hair volumizing composition comprised of a chelated copper chlorin compound, wherein the chelated copper chlorin compound is comprised of at least 75% of a chlorin species selected from the group consisting of trisodium copper (II) chlorin e6 and disodium copper (II) isochlorin e4, and the chelated copper chlorin compound is present at a concentration of from 0.02 to 0.1% by weight of the composition.

Abstract: Compositions and methods for treating and preventing inflammatory and autoimmune skin conditions, particularly rosacea, using one or more topically applied benzimidazole compounds in a pharmaceutically acceptable carrier for use on skin. A preferred benzimidazole compound comprises mebendazole. A treatment composition preferably comprises 0.05-0.075 weight percent mebendazole, and may comprise up to 20.0% mebendazole, in an aqueous carrier or vehicle comprising a cream, gel, lotion, liquid, emulsion, aerosol spray, non-aerosol spray,, suspension, or ointment and is applied at least once daily over a treatment period of at least two weeks to result in a reduction of cutaneous cytotoxic CD+8 T-cells, papules, pustules, swelling, appearance of redness or inflammation, and/or reduction in itchiness, and hot or burning sensation in the affected area compared to pre-treatment levels.

Abstract: Compositions and methods for treating alopecia, particularly chemotherapy-induced alopecia, using oxidizers or oxidants, pro-oxidant compounds, or activators of P53. Compositions comprising organic peroxides such as, cumene hydroperoxide, tert-Butyl hydroperoxide (t-BHP), hydrogen peroxide, benzoyl peroxide are preferred. Compositions may be applied subcutaneously, percutaneously, or topically. Most preferably, the compositions are applied to a treatment area prior to a round of chemotherapy to prevent or reduce hair loss in the treatment area.

Abstract: Compositions and methods for treating alopecia, particularly chemotherapy-induced alopecia, using oxidizers or oxidants, pro-oxidant compounds, or activators of P53. Compositions comprising organic peroxides such as, cumene hydroperoxide, tert-Butyl hydroperoxide (t-BHP), hydrogen peroxide, benzoyl peroxide are preferred. Compositions may be applied subcutaneously, percutaneously, or topically. Most preferably, the compositions are applied to a treatment area prior to a round of chemotherapy to prevent or reduce hair loss in the treatment area.

Abstract: Compositions and methods for treating and preventing inflammatory and autoimmune skin conditions, particularly rosacea, using one or more topically applied benzimidazole compounds in a pharmaceutically acceptable carrier for use on skin. A preferred benzimidazole compound comprises mebendazole. A treatment composition preferably comprises 0.05-0.20 weight percent mebendazole, and may comprise up to 20.0% mebendazole, in an aqueous or non-aqueous carrier or vehicle comprising a cream, gel, lotion, liquid, emulsion, microemulsion, aerosol spray, non-aerosol spray, serum, solution, suspension, or ointment and is applied at least once daily over a treatment period of at least two weeks to result in a reduction of cutaneous cytotoxic CD+8 T-cells, papules, pustules, swelling, appearance of redness or inflammation, and/or itchiness in the affected area compared to pre-treatment levels.

Abstract: Compositions and methods for treating cancer, particularly leukemia, using a cytotoxic composition comprising monocytes activated by ?-glucan. The monocytes are preferably incubated with the ?-glucan and then processed to extract particles, such as microvesicles and exosomes from the treated monocytes to produce the cytotoxic composition. Preferably the cytotoxic composition comprises at least 50% exosomes having a size of 150 nm or less that are activated with ?-glucan. Zymosan is the preferred ?-glucan. The cytotoxic composition has an apoptosis effect. When a subject having cancer is treated according to preferred embodiments, the cytotoxic composition preferably induces a cytokine response in the subject's immune system. The combination of the cytotoxic composition and cytokine response are synergistic.

Abstract: Compositions and methods for treating alopecia, particularly chemotherapy-induced alopecia, using oxidizers or oxidants, pro-oxidant compounds, or activators of P53. Compositions comprising organic peroxides such as, cumene hydroperoxide, tert-Butyl hydroperoxide (t-BHP), hydrogen peroxide, benzoyl peroxide are preferred. Compositions may be applied subcutaneously, percutaneously, or topically. Most preferably, the compositions are applied to a treatment area prior to a round of chemotherapy to prevent or reduce hair loss in the treatment area.

Abstract: Provided are compositions and methods for treatment of conditions and diseases of the skin, for example fine lines and wrinkles and rosacea. The compositions include a porphyrin that is a chlorophyllin, a chlorin compound, a complex of a chlorin compound, or a salt or ester of the chlorin compound or its complex.

Abstract: Sunless tanning compositions are substantially improved by adding methylsulfonyl methane [MSM] sequentially or simultaneously to compositions containing dihydroxyacetone [DHA].

Abstract: A method is provided for improving skin condition through a system whose steps include applying to the skin separately on a plurality of days a first composition that incorporates a retinoid which is either retinol or retinoic acid in a pharmaceutically acceptable carrier. Once the skin has acclimated to any irritation induced by the first composition, a second composition is applied to the skin daily for a subsequent period of time. The second composition will also include retinoid but at a level at least about 10% higher than that employed in the first composition. Once the skin has acclimated to the second composition, subsequent progressive increases of the active retinoid can be applied over subsequent periods of time. Finally, a maintenance level composition is utilized with the highest level of retinoid in the progressive program to minimize potential irritation.

Abstract: A method is provided for improving skin condition through a system whose steps include applying to the skin separately on a plurality of days a first composition that incorporates a C.sub.2 -C.sub.28 .alpha.- or .beta.-hydroxy carboxylic acid in a pharmaceutically acceptable carrier. Once the skin has acclimated to any irritation induced by the first composition, a second composition is applied to the skin daily for a subsequent period of time. The second composition will also include hydroxy carboxylic acid but at a level at least about 10% higher than that employed in the first composition. Once the skin has acclimated to the second composition, subsequent progressive increases of the active hydroxy carboxylic acid can be applied over subsequent periods of time Finally, a maintenance level composition is utilized with the highest level of hydroxy carboxylic acid in the progressive program to minimize potential irritation.

Abstract: A cosmetic composition is provided which includes green tea and a sunscreen compound which is effective to at least partially block ultraviolet radiation from harming human skin, and a pharmaceutically acceptable carrier.

Abstract: A process for the waving or straightening of hair by treating with an alkaline bisulphite and or sulfite preparation followed by neutralizing with hydrogen peroxide is improved by using an aqueous neutralizing solution in which the hydrogen peroxide is present in a concentration of from 0.65 to 3.4% by weight and proportional to the concentration by weight of available sulfur dioxide in the waving/straightening solution used prior to neutralization. The process avoids certain disadvantages associated with the prior art.