Patents by Inventor John P. Mueller

John P. Mueller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified myelin basic protein molecules
    Patent number: 7041503
    Abstract: Compositions and methods are provided for the clinical assessment, diagnosis, and treatment of multiple sclerosis. The compositions of the invention are molecules related to the 21.5 kDa fetal isoform of human myelin basic protein, and include nucleic acids and polypeptides. The nucleic acid molecules of the invention are useful in the efficient production of modified and unmodified 21.5 kDa myelin basic protein polypeptides, such polypeptides being useful for assaying T cells for responsiveness to myelin basic protein epitopes. The polypeptides of the invention are also useful as therapeutic agents that act by inducing T cell responses, including apoptosis, as a means of treating multiple sclerosis.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: May 9, 2006
    Assignees: The United States of America as represented by the Department of Health and Human Services, Alexion Pharmaceuticals, Inc.
    Inventors: Steven H. Nye, Michael J. Lenardo, Henry F. McFarland, Louis A. Matis, Eileen Elliott Mueller, John P. Mueller, Clara M. Pelfrey, Stephen P. Squinto, James A. Wilkins
  • MODIFIED MYELIN BASIC PROTEIN MOLECULES
    Publication number: 20040180808
    Abstract: Compositions and methods are provided for the clinical assessment, diagnosis, and treatment of multiple sclerosis. The compositions of the invention are molecules related to the 21.5 kDa fetal isoform of human myelin basic protein, and include nucleic acids and polypeptides. The nucleic acid molecules of the invention are useful in the efficient production of modified and unmodified 21.5 kDa myelin basic protein polypeptides, such polypeptides being useful for assaying T cells for responsiveness to myelin basic protein epitopes. The polypeptides of the invention are also useful as therapeutic agents that act by inducing T cell responses, including apoptosis, as a means of treating multiple sclerosis.
    Type: Application
    Filed: May 2, 1995
    Publication date: September 16, 2004
    Inventors: STEVEN H. NYE, MICHAEL J. LENARDO, HENRY F. MCFARLAND, LOUIS A. MATIS, EILEEN E. MUELLER, JOHN P. MUELLER, CLARA M. PELFREY, STEPHEN P. SQUINTO, JAMES A. WILKINS
  • HarA polypeptides and nucleic acids, and related methods and uses thereof
    Publication number: 20030157491
    Abstract: The present invention relates to harA polypeptides and nucleic acids encoding harA polypeptides and mutants thereof, derived from Enterococcus faecalis and Bacillus subtilis, as well as methods of using the polypeptides and nucleic acids in screening and diagnostic methods.
    Type: Application
    Filed: January 30, 2002
    Publication date: August 21, 2003
    Inventors: John P. Mueller, Eric T. Baima