Abstract: This technology relates in part to optical methods for analyzing particles, including nanoparticles, thereby determining their presence, identity, origin, size and/or number in a sample of interest.

Abstract: This technology relates in part to optical methods for analyzing particles, including nanoparticles, thereby determining their presence, identity, origin, size and/or number in a sample of interest.

Abstract: This technology relates in part to optical methods for analyzing particles, including nanoparticles, thereby determining their presence, identity, origin, size and/or number in a sample of interest.

Abstract: This technology relates in part to optical methods for analyzing particles, including nanoparticles, thereby determining their presence, identity, origin, size and/or number in a sample of interest.

Abstract: This technology relates in part to optical methods for analyzing particles, including nanoparticles, thereby determining their presence, identity, origin, size and/or number in a sample of interest.

Abstract: A method and an apparatus to adapt the performance of a cathode humidification unit as a membrane in a fuel cell stack degrades over time. An algorithm compares a sensed humidity profile of the fuel cell stack and model humidity profile of a cathode humidification unit model to calculate a new degradation factor. The cathode humidification unit model uses the degradation factor in the performance of the cathode humidification unit.

Abstract: System and methods for controlling and optimizing coolant system parameters in a fuel cell system to obtain a requested cabin temperature in a fuel cell vehicle are presented. A method for managing a temperature in a vehicle cabin may include receiving an indication relating to a desired vehicle cabin temperature and a plurality of measured operating parameters. Based on the measured operating parameters, a projected output temperature of a cabin heat exchanger may be estimated. A determination may be made that the projected output temperature of the cabin heat exchanger is less than the indication. Based on the determination a fuel cell coolant parameter may be adjusted.

Abstract: A system and method for operating a fuel cell stack of a fuel cell system in a vehicle when an error in cathode air flow rate is detected. The system and method include estimating a cathode air flow rate and detecting an error in the estimated cathode air flow rate. The system and method also include utilizing high frequency resistance measurements from a high frequency resistance sensor to control a relative humidity of the fuel cell stack when the error in the estimated cathode air flow rate has been detected.

Abstract: A system and method for determining if an RH sensor that measures the relative humidity of cathode inlet air provided to a fuel cell stack or an HFR circuit that measures stack water content is operating properly. The method provides the cathode inlet air through a WVT unit that increases the water content of the cathode inlet air. The method uses a water buffer model for determining the water content of the fuel cell stack based on inputs from a plurality of system components and revises a water transfer model using the HFR humidification signal or the RH signal to correct for WVT unit degradation. The method determines whether the RH sensor or the HFR circuit is operating properly, such as by determining if the HFR humidification signal is increasing at a rate that is faster than what the stack water content is able to increase.

Abstract: System and methods for controlling and optimizing coolant system parameters in a fuel cell system to obtain a requested cabin temperature in a fuel cell vehicle are presented. A method for managing a temperature in a vehicle cabin may include receiving an indication relating to a desired vehicle cabin temperature and a plurality of measured operating parameters. Based on the measured operating parameters, a projected output temperature of a cabin heat exchanger may be estimated. A determination may be made that the projected output temperature of the cabin heat exchanger is less than the indication. Based on the determination a fuel cell coolant parameter may be adjusted.

Abstract: A method and an apparatus to adapt the performance of a cathode humidification unit as a membrane in a fuel cell stack degrades over time. An algorithm compares a sensed humidity profile of the fuel cell stack and model humidity profile of a cathode humidification unit model to calculate a new degradation factor. The cathode humidification unit model uses the degradation factor in the performance of the cathode humidification unit.

Abstract: A system and method for operating a fuel cell stack of a fuel cell system in a vehicle when an error in cathode air flow rate is detected. The system and method include estimating a cathode air flow rate and detecting an error in the estimated cathode air flow rate. The system and method also include utilizing high frequency resistance measurements from a high frequency resistance sensor to control a relative humidity of the fuel cell stack when the error in the estimated cathode air flow rate has been detected.

Abstract: A system and method for determining if an RH sensor that measures the relative humidity of cathode inlet air provided to a fuel cell stack or an HFR circuit that measures stack water content is operating properly. The method provides the cathode inlet air through a WVT unit that increases the water content of the cathode inlet air. The method uses a water buffer model for determining the water content of the fuel cell stack based on inputs from a plurality of system components and revises a water transfer model using the HFR humidification signal or the RH signal to correct for WVT unit degradation. The method determines whether the RH sensor or the HFR circuit is operating properly, such as by determining if the HFR humidification signal is increasing at a rate that is faster than what the stack water content is able to increase.

Abstract: Systems and methods to control the delivery of coolant to a coolant loop within a vehicular fuel cell system. During periods of low power output from one or more fuel cell stacks, operation of a pump used to circulate coolant through the loop is intermittent, thereby reducing pump usage during such times. The frequency of pump operation, as measured by a pump on/off (i.e., pulsed) cycle, may be adjusted to keep a local temperature rise within the one or more stacks to no more than a small amount over the bulk stack temperature.

Abstract: The present invention is directed to processes of separating, analyzing and/or collecting selected species within a target sample by use of magnetic microspheres including magnetic particles, the magnetic microspheres adapted for attachment to a receptor agent that can subsequently bind to selected species within the target sample. The magnetic microspheres can be sorted into a number of distinct populations, each population with a specific range of magnetic moments and different receptor agents can be attached to each distinct population of magnetic microsphere.

Abstract: The present invention provides methods and kits for detecting chromosome translocations. The present invention further provides methods for diagnosing cancer.

Abstract: Methods for rapidly detecting single or multiple sequence alleles in a sample nucleic acid are described. Provided are all of the oligonucleotide pairs capable of annealing specifically to a target allele and discriminating among possible sequences thereof, and ligating to each other to form an oligonucleotide complex when a particular sequence feature is present (or, alternatively, absent) in the sample nucleic acid. The design of each oligonucleotide pair permits the subsequent high-level PCR amplification of a specific amplicon when the oligonucleotide complex is formed, but not when the oligonucleotide complex is not formed. The presence or absence of the specific amplicon is used to detect the allele. Detection of the specific amplicon may be achieved using a variety of methods well known in the art, including without limitation, oligonucleotide capture onto DNA chips or microarrays, oligonucleotide capture onto beads or microspheres, electrophoresis, and mass spectrometry.

Abstract: Methods for rapidly detecting single or multiple sequence alleles in a sample nucleic acid are described. Provided are all of the oligonucleotide pairs capable of annealing specifically to a target allele and discriminating among possible sequences thereof, and ligating to each other to form an oligonucleotide complex when a particular sequence feature is present (or, alternatively, absent) in the sample nucleic acid. The design of each oligonucleotide pair permits the subsequent high-level PCR amplification of a specific amplicon when the oligonucleotide complex is formed, but not when the oligonucleotide complex is not formed. The presence or absence of the specific amplicon is used to detect the allele. Detection of the specific amplicon may be achieved using a variety of methods well known in the art, including without limitation, oligonucleotide capture onto DNA chips or microarrays, oligonucleotide capture onto beads or microspheres, electrophoresis, and mass spectrometry.

Abstract: The present invention is directed to processes of separating, analyzing and/or collecting selected species within a target sample by use of magnetic microspheres including magnetic particles, the magnetic microspheres adapted for attachment to a receptor agent that can subsequently bind to selected species within the target sample. The magnetic microspheres can be sorted into a number of distinct populations, each population with a specific range of magnetic moments and different receptor agents can be attached to each distinct population of magnetic microsphere.

Abstract: The present invention provides methods and kits for detecting chromosome translocations. The present invention further provides methods for diagnosing cancer.