Patents by Inventor John P. O'Daly
John P. O'Daly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7455975Abstract: An electrochemical detection system which specifically detects selected nucleic acid segments is described. The system utilizes biological probes such as nucleic acid or peptide nucleic acid probes which are complementary to and specifically hybridize with selected nucleic acid segments in order to generate a measurable current when an amperometric potential is applied. The electrochemical signal can be quantified.Type: GrantFiled: January 3, 2007Date of Patent: November 25, 2008Assignee: ESA Biosciences, Inc.Inventors: Robert W. Henkens, John P. O'Daly, Marek Wojciechowski, Honghua Zhang, Najih Naser, R. Michael Roe, Thomas N. Stewart, Deborah M. Thompson, Rebecca Sundseth, Steven E. Wegner
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Patent number: 7169358Abstract: An electrochemical detection system which specifically detects selected nucleic acid segments is described. The system utilizes biological probes such as nucleic acid or peptide nucleic acid probes which are complementary to and specifically hybridize with selected nucleic acid segments in order to generate a measurable current when an amperometric potential is applied. The electrochemical signal can be quantified.Type: GrantFiled: February 25, 2002Date of Patent: January 30, 2007Inventors: Robert W. Henkens, John P. O'Daly, Marek Wojciechowski, Honghua Zhang, Najih Naser, R. Michael Roe, Thomas N. Stewart, Deborah M. Thompson, Rebecca Sundseth, Steven E. Wegner
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Publication number: 20040072158Abstract: An electrochemical detection system which specifically detects selected nucleic acid segments is described. The system utilizes biological probes such as nucleic acid or peptide nucleic acid probes which are complementary to and specifically hybridize with selected nucleic acid segments in order to generate a measurable current when an amperometric potential is applied. The electrochemical signal can be quantified.Type: ApplicationFiled: February 25, 2002Publication date: April 15, 2004Inventors: Robert W. Henkens, John P. O'Daly, Marek Wojciechowski, Honghua Zhang, Najih Naser, R. Michael Roe, Thomas N. Stewart, Deborah M. Thompson, Rebecca Sundseth, Steven E. Wegner
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Patent number: 6391558Abstract: An electrochemical detection system which specifically detects selected nucleic acid segments is described. The system utilizes biological probes such as nucleic acid or peptide nucleic acid probes which are complementary to and specifically hybridize with selected nucleic acid segments in order to generate a measurable current when an amperometric potential is applied. The electrochemical signal can be quantified.Type: GrantFiled: April 14, 2000Date of Patent: May 21, 2002Assignee: Andcare, Inc.Inventors: Robert W. Henkens, John P. O'Daly, Marek Wojciechowski, Honghua Zhang, Najih Naser, R. Michael Roe, Thomas N. Stewart, Deborah M. Thompson, Rebecca Sundseth, Steven E. Wegner
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Patent number: 5873990Abstract: An apparatus is disclosed which is a microprocessor based instrument designed to conveniently and rapidly measure various analytes in environmental and biological samples. The instrument operates as a stand-alone unit powered by a battery or a DC power module and may be equipped with a communication port allowing uploading test results to a computer. Several unique electronic, microchip and software configurations were developed for the device to make it a portable, low-cost, safe, automated and simple-to-operate instrument particularly adapted for precise and accurate measurement of metal ions such as heavy metals such as lead in human blood.Type: GrantFiled: August 21, 1996Date of Patent: February 23, 1999Assignee: Andcare, Inc.Inventors: Marek Wojciechowski, Frederick A. Ebeling, Robert W. Henkens, Najih A. Naser, John P. O'Daly, Steven E. Wegner
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Patent number: 5468366Abstract: The present invention provides a new device for use in measuring lead levels in biological and environmental samples. Using square wave coulometry and colloidal gold particles impregnated on carbon electrodes, the present invention provides a rapid, reliable, portable and inexpensive means of detecting low lead levels. The colloidal gold modified electrodes have microelectrode array characteristics and produce significantly higher stripping detection signals for lead than are produced at bulk gold electrode surfaces. The method is effective in determining levels of lead down to at least 5 .mu.g/dL in blood samples as small as 10 .mu.L.Type: GrantFiled: September 30, 1994Date of Patent: November 21, 1995Assignee: Andcare, Inc.Inventors: Steven Wegner, Michael A. Harpold, Terence M. McCaffrey, Susan E. Morris, Marek Wojciechowski, Junguo Zhao, Robert W. Henkens, Najih Naser, John P. O'Daly
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Patent number: 5391272Abstract: An electro-immunosensor which can be used to determine the presence of a wide range of analytes in solution is described. Also described are methods of determining subnanogram levels of analytes in a one-step procedure. This novel immunosensor comprises an analyte binding agent bound to an electrode and a analyte/enzyme conjugate bound to the analyte binding agent as part of a catalytic electrical circuit. Displacement of the conjugate by analyte causes a proportional decrease in current. The immunosensor may also be adapted to detect two analytes in a single step by using different enzymes conjugated to the analyte binding agents.Type: GrantFiled: March 8, 1994Date of Patent: February 21, 1995Assignee: Andcare, Inc.Inventors: John P. O'Daly, Robert W. Henkens, Junguo Zhao, Honghua Zhang
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Patent number: 5368707Abstract: The invention relates to methods of determining micromolar levels of lead ion in various fluids, including blood. Detection of lead or other heavy metal ion concentrations as low as 1 .mu.g/dL is achieved. The methods are adaptable to the detection of low levels of lead in whole blood, employing a novel separation and release of lead ion from lead chelating agents. The disclosed methods employ isocitrate dehydrogenase-based electrodes which are particularly suited for detecting nanomolar levels of lead.Type: GrantFiled: June 7, 1993Date of Patent: November 29, 1994Assignee: Andcare, Inc.Inventors: Robert W. Henkens, Junguo Zhao, Marek Wojciechowski, John P. O'Daly, Zhi-Wei Liang, Susan E. Morris
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Patent number: 5334296Abstract: Horseradish peroxidase (HRP) immobilized on colloidal gold and then deposited on an electrode surface can be reduced at a convenient rate at low voltage (Ag/AgCl) without an electron transfer mediator. Bioelectrodes combining both a colloidal gold-adsorbed oxidase and colloidal gold-adsorbed HRP located on an electrode surface are efficient biodetectors, particularly for the measurement of low glucose levels in samples when glucose oxidase is employed as the sensing enzyme. The biodetectors may be employed for mediatorless detection of a wide variety of analytyes depending on the oxidase employed.Type: GrantFiled: June 28, 1993Date of Patent: August 2, 1994Assignee: Andcare, Inc.Inventors: Robert W. Henkens, Junguo Zhao, John P. O'Daly
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Patent number: 5262313Abstract: Carrageenan-immobilized enzymes are prepared that are stable and retain high activity toward substrates when used in substantially water-immiscible organic solvents. The carrageenan-immobilized enzymes are preferably prepared by introducing droplets of an enzyme/carrageenan solution into a chilled alcohol saturated with a potassium salt and hardening the droplets in the alcohol. The alcohol is selected from n-butanol, benzyl alcohol, crotyl alcohol, n-propanol, isopropanol and sec-butanol. Reactions catalyzed by a .kappa.-carrageenan-immobilized esterase include steroselective transesterifications and hydrolysis reactions.Type: GrantFiled: June 14, 1991Date of Patent: November 16, 1993Assignee: Andcare, Inc.Inventors: Barbara S. Kitchell, Robert W. Henkens, Philip Brown, Steven W. Baldwin, Charles H. Lochmuller, John P. O'Daly
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Patent number: 5225064Abstract: Horseradish peroxidase (HRP) immobilized on colloidal gold and then deposited on an electrode surface can be reduced at a convenient rate at low voltage (Ag/AgCl) without an electron transfer mediator. Bioelectrodes combining both a colloidal gold-adsorbed oxidase and colloidal gold-adsorbed HRP located on an electrode surface are efficient biodetectors, particularly for the measurement of low glucose levels in samples when glucose oxidase is employed as the sensing enzyme. The biodetectors may be employed for mediatorless detection of a wide variety of analytes depending on the oxidase employed.Type: GrantFiled: March 6, 1992Date of Patent: July 6, 1993Assignee: Enzyme Technology Research Group, Inc.Inventors: Robert W. Henkens, Junguo Zhao, John P. O'Daly
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Patent number: 5217594Abstract: The invention relates to novel b of detecting metal ion concentrations less than about 10 .mu.g/dl fluid. Biosensors based on the enzyme isocitrate dehydrogenase are particularly suited for detecting trace lead ion concentrations in water and in blood. Bioelectrodes are fabricated from surface deposited colloidal gold adsorbed enzyme that retains high catalytic activity Other aspects of the invention include detection devices for convenient and rapid measurement of metal ions.Type: GrantFiled: January 15, 1992Date of Patent: June 8, 1993Assignee: Enzyme Technology Research Group, Inc.Inventors: Robert W. Henkens, Junguo Zhao, John P. O'Daly