Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A sound damping wallboard and methods of forming a sound damping wallboard are disclosed. The sound damping wallboard comprises a gypsum layer with a gypsum surface having an encasing layer. The encasing layer is partially removed to expose the gypsum surface and form a gypsum surface portion and a first encasing layer portion on the gypsum layer. A sound damping layer is applied to the gypsum layer to cover at least part of the gypsum surface portion and the encasing layer portion.

Abstract: An apparatus and a system for stably positioning a nasal cannula in a manner effective for oral or nasal delivery of oxygen or gas mixtures to an individual are described. A generally rectangular cannula support member having at least one retention device secures a nasal cannula to the support member. A pad may be disposed between the support member and the face of the person to assist in positioning the support member without the requirement of tape, and for reducing skin irritation. Depending on the size of the cannula support member, the support member may be constructed from flexible materials to conform to the facial features of the wearer. The apparatus and the system may further include a flexible strip having shape memory.

Abstract: A harness for securely positioning a nasal cannula on the face of a person for orally administering oxygen and other gases is described. A flexible chin strap adapted for placement around the chin of the person may be attached to adjustable, flexible straps effective for draping around the ears of the person, which are in turn attached to a central, cannula attachment portion disposed between the cannula and the face of the person. The gas delivery tubes of the cannula are also disposed behind the ears, essentially following the path of the flexible straps of the harness. Once placed on a person, the harness holds the nasal cannula such that the nasal prongs may disposed facing toward the mouth opening in the vicinity of the lower lip thereof, and may deliver gases to a mouth-breathing individual. Another embodiment of the harness may be utilized to position a nasal cannula for nasal administration of gas.

Abstract: An apparatus and a system for stably positioning a nasal cannula in a manner effective for oral or nasal delivery of oxygen or gas mixtures to an individual are described. A generally rectangular cannula support member having at least one retention device secures a nasal cannula to the support member. A pad may be disposed between the support member and the face of the person to assist in positioning the support member without the requirement of tape, and for reducing skin irritation. Depending on the size of the cannula support member, the support member may be constructed from flexible materials to conform to the facial features of the wearer. The apparatus and the system may further include a flexible strip having shape memory.

Abstract: A method and a computer program for estimating item quantities in a building project that includes one or more items. The method includes steps for providing a spreadsheet template including a summary worksheet and one or more input worksheets with a plurality of cells for estimating a quantity of an item in a building project comprising one or more items, receiving a value of a parameter inputted by a user in a predetermined cell of an input worksheet, calculating the quantity of the item based on the value and a formula for the item, and generating a list including the quantity of the item on the summary worksheet. The program includes codes for performing the method and the spreadsheet template may be used by a spreadsheet program such as MICROSOFT EXCEL.

Abstract: A harness for securely positioning a nasal cannula on the face of a person for orally administering oxygen and other gases is described. A flexible chin strap adapted for placement around the chin of the person may be attached to adjustable, flexible straps effective for draping around the ears of the person, which are in turn attached to a central, cannula attachment portion disposed between the cannula and the face of the person. The gas delivery tubes of the cannula are also disposed behind the ears, essentially following the path of the flexible straps of the harness. Once placed on a person, the harness holds the nasal cannula such that the nasal prongs may disposed facing toward the mouth opening in the vicinity of the lower lip thereof, and may deliver gases to a mouth-breathing individual. Another embodiment of the harness may be utilized to position a nasal cannula for nasal administration of gas.