Abstract: A compound having the following structure of Formula (IV): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, A, B, X, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: Provided herein are VHH-containing polypeptides that bind ?? T-cells. Uses of the VHH-containing polypeptides are also provided.

Abstract: An apparatus and method of linear frequency modulation waveform bandwidth multiplication including a digital linear frequency modulation waveform synthesizer for generating a synthesized waveform having an upchirp component of linearly varying frequency during a first half signal duration of the synthesized waveform followed by a downchirp component having linearly varying frequency during a second half of the signal duration of the synthesized waveform. The synthesized waveform is upconverted and subsequently bandpass filtered to provide a filtered waveform to a mixer for mixing with local oscillation signals. The upchirp and downchirp components of the filtered waveform are respectively mixed by first and second local oscillation signals having respective first and second oscillation frequencies in the mixer.

Abstract: One meter and one foot resolution is achieved in a multi-mode SAR radar system in real time by wide bandwidth RF signal generation, precision motion compensation, polar reformatting, autofocusing and high dynamic range image processing. An exciter/receiver of this system includes means for providing wideband RF waveform generation and down-conversion, while a programmable digital signal processor includes improvements in software for implementing the functions of motion compensation including the presuming of data, polar reformatting, autofocusing and image processing.

Abstract: An apparatus for forming a weld between first and second thermoplastic materials in which the softening temperature of the second thermoplastic material is lower than that of the first thermoplastic material. The apparatus includes a supplier for supplying the first thermoplastic material and the second thermoplastic material to the same weld position with the second thermoplastic material at a first side of the first thermoplastic material, and a projector for projecting a laser beam to the weld position from a second side of the first thermoplastic material.

Abstract: A double zipper pouch having first and second pockets adjacent one another and with a common wall portion, each pocket having an opening for receiving contents such as identification papers. The first and second pockets are formed so that their openings are displaced relative to one another. Pressure actuated resealable fasteners are disposed adjacent the openings in each of the first and second pockets. First and second indicators are also disposed adjacent the openings to provide an indication of the location of the associated opening. The indicators are preferably different from one another so as to provide an identification for the associated pocket. An adhesive material is formed on the back of the first pocket for affixing the pouch to, for example, a package.

Abstract: A double zipper pouch having first and second pockets adjacent one another and with a common wall portion, each pocket having an opening for receiving contents such as identification papers. The first and second pockets are formed so that their openings are displaced relative to one another. Pressure actuated resealable fasteners are disposed adjacent the openings in each of the first and second pockets. First and second indicators are also disposed adjacent the openings to provide an indication of the location of the associated opening. The indicators are preferably different from one another so as to provide an identification for the associated pocket. An adhesive material is formed on the back of the first pocket for affixing the pouch to, for example, a package.