Patents by Inventor John P. Verge
John P. Verge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4769482Abstract: This invention provides novel alkane derivatives which are leukotriene antagonists, formulations of those derivatives, and a method of using those derivatives for the treatment of conditions characterized by an excessive release of leukotrienes.Type: GrantFiled: December 15, 1986Date of Patent: September 6, 1988Assignee: Eli Lilly and CompanyInventors: Winston S. Marshall, John P. Verge
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Patent number: 4740514Abstract: There are described compounds of the formula ##STR1## in which R.sup.1 is hydrogen or C.sub.1-6 alkyl, R.sup.2 is hydrogen, C.sub.1-6 alkyl or C.sub.3-6 alkenyl, X and Y are each oxygen, sulphur, sulphinyl or sulphonyl, n is 2 to 6 and Z is 1H-tetrazol-5-yl, 1H-tetrazol-5-ylthio, 1H-tetrazol-5-ylsulphinyl, 1H-tetrazol-5-ylsulphonyl, cyano or thiocyano, provided that when both X and Y are oxygen Z is 1H-tetrazol-5-ylthio, 1H-tetrazol-5-ylsulphinyl, 1H-tetrazol-5-ylsulphonyl or thiocyano; and salts thereof. The compounds in which Z is other than cyano or thiocyano have pharmaceutical activity and inhibit leukotriene action or formation.Type: GrantFiled: May 27, 1986Date of Patent: April 26, 1988Assignee: Lilly Industries LimitedInventors: John Goldsworthy, Winston S. Marshall, John P. Verge
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Patent number: 4675334Abstract: Compounds of formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently selected from H, OH, C.sub.1 -C.sub.4 alkyl, R.sub.4 --CO and halogen, where R.sub.4 is C.sub.1 -C.sub.4 alkyl; R.sub.5 and R.sub.6 are each independently selected from H, C.sub.1 -C.sub.4 alkyl and optionally-substituted phenyl; R.sub.7 is an alkylene group having from 1 to 4 carbon atoms, optionally containing a substituted or unsubstituted phenyl group; p is 0 or 1; and Z is a 1H-tetrazol-5-yl or a --CN group; and salts thereof, may be prepared by reacting a compound of formula. ##STR2## with a compound of formula ##STR3## wherein R.sub.1 -R.sub.7 are as defined in claim 1, in an organic solvent at a temperature in the range of 40.degree.-120.degree. C.Type: GrantFiled: July 11, 1984Date of Patent: June 23, 1987Assignee: Lilly Industries LimitedInventors: David J. Steggles, John P. Verge
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Patent number: 4675333Abstract: There are described compounds of the formula ##STR1## in which R.sup.1 is hydrogen or C.sub.1-6 alkyl, R.sup.2 is hydrogen, C.sub.1-6 alkyl or C.sub.3-6 alkenyl, R.sup.3 is hydrogen or C.sub.1-6 alkyl, R.sup.4 is hydrogen or an N-protecting group, n is 2, 3, 4 or 5, and X is oxygen, sulphur or --CH.sub.2 --, provided that when X is --CH.sub.2 -- n is 0; and salts thereof. The compounds in which R.sup.4 is hydrogen have pharmaceutical activity.Type: GrantFiled: December 5, 1984Date of Patent: June 23, 1987Assignee: Lilly Industries LimitedInventors: David J. Steggles, John P. Verge
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Patent number: 4661505Abstract: This invention provides novel alkane derivatives which are leukotriene antagonists, formulations of those derivatives, and a method of using those derivatives for the treatment of conditions characterized by an excessive release of leukotrienes.Type: GrantFiled: November 3, 1982Date of Patent: April 28, 1987Assignee: Eli Lilly and CompanyInventors: Winston S. Marshall, John P. Verge
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Patent number: 4595540Abstract: There are described compounds of the formula ##STR1## in which R.sup.1 is hydrogen or C.sub.1-6 alkyl, R.sup.2 is hydrogen, C.sub.1-6 alkyl or C.sub.3-6 alkenyl, X and Y are each oxygen, sulphur, sulphinyl or sulphonyl, n is 2 to 6 and Z is 1H-tetrazol-5-yl, 1H-tetrazol-5-ylthio, 1H-tetrazol-5-ylsulphinyl, 1H-tetrazol-5-ylsulphonyl, cyano or thiocyano, provided that when both X and Y are oxygen Z is 1H-tetrazol-5-ylthio, 1H-tetrazol-5-ylsulphinyl, 1H-tetrazol-5-ylsulphonyl or thiocyano; and salts thereof. The compounds in which Z is other than cyano or thiocyano have pharmaceutical activity and inhibit leukotriene action or formation.Type: GrantFiled: October 19, 1983Date of Patent: June 17, 1986Assignee: Lilly Industries LimitedInventors: John Goldsworthy, Winston S. Marshall, John P. Verge
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Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease
Patent number: 4390541Abstract: Compounds of the following formula are described: ##STR1## in which n is 0, 1 or 2, R.sup.1 is C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphonyl, trifluoromethyl, halo or nitro, and R.sup.2 and R.sup.3 are each independently hydrogen or C.sub.1-4 alkyl, and salts thereof. The compounds are useful in the treatment of immediate hypersensitivity conditions and are prepared by reaction of the appropriate formylquinolone with malonic acid, ylid or phosphonate.Type: GrantFiled: December 3, 1981Date of Patent: June 28, 1983Assignee: Lilly Industries LimitedInventors: John Goldsworthy, William J. Ross, John P. Verge -
Patent number: 4293563Abstract: Novel hydantoin compounds are described of the formula (I): ##STR1## wherein Ar is phenyl optionally substituted by up to three radicals selected from the group comprising C.sub.1-6 alkoxy, halogen, 1,3-dioxol-2-yl, hydroxy C.sub.1-4 alkoxy C.sub.1-4 alkyl, phenyl, hydroxyl, nitrile, C.sub.1-4 haloalkyl, C.sub.1-4 alkyl, C.sub.2-4 alkenyloxy, C.sub.1-4 alkoxycarbonyl or phenoxy optionally substituted by C.sub.1-4 haloalkyl, C.sub.1-4 alkoxy or halogen;or is thiophene optionally substituted by phenyl or by one or two C.sub.1-4 alkyl groups;R.sup.1 and R.sup.2 are independently hydrogen or taken together represent a chemical bond;R.sup.3 is hydrogen, C.sub.1-6 alkyl or C.sub.2-4 alkenyl; andR.sup.4 is C.sub.1-6 alkyl, C.sub.2-4 alkenyl, phenyl or benzyl;provided that R.sup.3 cannot be hydrogen when Ar is unsubstituted phenyl and R.sup.4 is n-butyl. The compounds are useful in the treatment of immediate hypersensitivity diseases including asthma.Type: GrantFiled: May 12, 1980Date of Patent: October 6, 1981Assignee: Lilly Industries LimitedInventors: William B. Jamieson, William J. Ross, Robin G. Simmonds, John P. Verge
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Patent number: 4259343Abstract: A class of novel 2-oxazolyl ureas and carbamates having anti-allergic activity are described together with methods of making such compounds and pharmaceutical compositions containing the active compounds of the invention.Type: GrantFiled: February 5, 1979Date of Patent: March 31, 1981Assignee: Lilly Industries LimitedInventors: William J. Ross, Alec Todd, John P. Verge
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Patent number: 4241073Abstract: Novel hydantoin compounds are described of the formula (I): ##STR1## wherein Ar is phenyl optionally substituted by up to three radicals selected from the group comprising C.sub.1-6 alkoxy, halogen, 1,3-dioxol-2-yl, hydroxy C.sub.1-4 alkoxy C.sub.1-4 alkyl, phenyl, hydroxyl, nitrile, C.sub.1-4 haloalkyl, C.sub.1-4 alkyl, C.sub.2-4 alkenyloxy, C.sub.1-4 alkoxycarbonyl or phenoxy optionally substituted by C.sub.1-4 haloalkyl, C.sub.1-4 alkoxy or halogen;or is thiophene optionally substituted by phenyl or by one or two C.sub.1-4 alkyl groups;R.sup.1 and R.sup.2 are independently hydrogen or taken together represent a chemical bond;R.sup.3 is hydrogen, C.sub.1-6 alkyl or C.sub.2-4 alkenyl; andR.sup.4 is C.sub.1-6 alkyl, C.sub.2-4 alkenyl, phenyl or benzyl;provided that R.sup.3 cannot be hydrogen when Ar is unsubstituted phenyl and R.sup.4 is n-butyl. The compounds are useful in the treatment of immediate hypersensitivity diseases including asthma.Type: GrantFiled: May 14, 1979Date of Patent: December 23, 1980Assignee: Lilly Industries LimitedInventors: William B. Jamieson, William J. Ross, Robin G. Simmonds, John P. Verge
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Patent number: 4230709Abstract: Pharmaceutical formulations are described, which comprise a hydantoin of formula (I): ##STR1## wherein R.sup.1 is C.sub.1-4 alkyl, R.sup.2 is hydrogen or C.sub.1-4 alkyl; or R.sup.1 and R.sup.2 taken together either represent a C.sub.4-6 alkylene group or a group of formula: ##STR2## where R.sup.5 and R.sup.6 independently represent hydrogen or C.sub.1-4 alkyl;R.sup.3 is C.sub.1-6 alkyl or benzyl;R.sup.4 is hydrogen or C.sub.1-6 alkyl;provided that R.sup.2 and R.sup.4 cannot both be hydrogen;or R.sup.1 and R.sup.4 taken together represent a C.sub.2-4 alkylene group;associated with a pharmaceutically-acceptable carrier therefor. The compounds, some of which are novel, are useful in the treatment of immediate hypersensitivity diseases such as asthma.Type: GrantFiled: May 14, 1979Date of Patent: October 28, 1980Assignee: Lilly Industries LimitedInventors: William B. Jamieson, William J. Ross, Robin G. Simmonds, John P. Verge
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Patent number: 4230716Abstract: Hydantoin compounds are described of the formula (I) : ##STR1## wherein R.sup.1 is phenyl, C.sub.1-4 hydroxyalkyl or carboxy C.sub.1-4 alkyl and wherein R.sub.2 is C.sub.1-6 alkyl. The compounds are useful in the prophylactic treatment of immediate hypersensitivity diseases including asthma.Type: GrantFiled: May 14, 1979Date of Patent: October 28, 1980Assignee: Eli Lilly Industries LimitedInventors: William B. Jamieson, William J. Ross, Robin G. Simmonds, John P. Verge
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Patent number: 4175131Abstract: A class of novel 2-oxazolyl ureas and carbamates having anti-allergic activity are described together with methods of making such compounds and pharmaceutical compositions containing the active compounds of the invention.Type: GrantFiled: December 27, 1977Date of Patent: November 20, 1979Assignee: Lilly Industries LimitedInventors: William J. Ross, Alex Todd, John P. Verge
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Patent number: 4166818Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,2,4-oxadiazole or 1,2,4-thiadiazole nucelus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.Type: GrantFiled: October 11, 1977Date of Patent: September 4, 1979Assignee: Lilly Industries LimitedInventors: William J. Ross, John P. Verge, William R. N. Williamson
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Patent number: 4163048Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,2,4-oxadiazole or 1,2,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds having anti-allergy activity.Type: GrantFiled: June 13, 1977Date of Patent: July 31, 1979Assignee: Lilly Industries LimitedInventors: William J. Ross, John P. Verge, William R. N. Williamson
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Patent number: 4158659Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.Type: GrantFiled: October 7, 1977Date of Patent: June 19, 1979Assignee: Lilly Industries LimitedInventors: William J. Ross, John P. Verge, William R. N. Williamson
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Patent number: 4152442Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.Type: GrantFiled: June 22, 1977Date of Patent: May 1, 1979Assignee: Lilly Industries LimitedInventors: William J. Ross, John P. Verge, William R. N. Williamson
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Patent number: 4150143Abstract: Oxazoles which are substituted in the 2,4 or 5-position with an N-substituted-acylamino group have anti-allergic activity. Methods of making such compounds, pharmaceutical compositions containing the active compounds of the invention and methods of treating asthma utilizing such compounds are provided.Type: GrantFiled: March 21, 1977Date of Patent: April 17, 1979Assignee: Lilly Industries LimitedInventors: Martin C. Neville, John P. Verge
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Patent number: 4123529Abstract: Phenylpiperazine derivatives of formula (I): ##STR1## where R.sup.1 is benzyl, C.sub.1-6 alkyl or optionally substituted phenyl; R.sup.2 is optionally substituted phenyl; R.sup.3 is hydrogen or C.sub.1-4 alkyl; Q is furan, thiophene, oxazole or thiazole; m is 1 to 3 and n is 0 or 1; and pharmaceutically-acceptable salts thereof are active in the chemotherapy of immediate hypersensitivity conditions such as asthma.Type: GrantFiled: July 8, 1977Date of Patent: October 31, 1978Assignee: Lilly Industries LimitedInventors: John P. Verge, William B. Jamieson
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Patent number: 4122183Abstract: A class novel 2,4 or 5-acylamino oxazoles having anti-allergic activity, methods of making such compounds and pharmaceutical compositions containing the active compounds of the invention. The compounds of the invention have been shown to be useful in the prophylactic and therapeutic treatment of immediate hypersensitivity diseases including asthma and in the alleviation of status asthmaticus.Type: GrantFiled: February 9, 1977Date of Patent: October 24, 1978Assignee: Lilly Industries LimitedInventors: Martin C. Neville, John P. Verge