Abstract: The invention is a method of predicting recurrence of colorectal cancer in a patient following surgery, the method comprising analysis of circulating tumor DNA from a patient's sample.

Abstract: The invention is a method of predicting response to therapy in a colorectal cancer patient, the method comprising analysis of circulating tumor DNA from a patient's sample.

Abstract: The invention is a method of predicting response to therapy in a colorectal cancer patient, the method comprising analysis of circulating tumor DNA from a patient's sample.

Abstract: The invention is a method of determining a likelihood that a cancer patient will respond to immunotherapy based on a mutation metric obtained by sequencing a small panel of nucleic acid targets in patient's cell-free DNA.

Abstract: The invention is a method of predicting recurrence of colorectal cancer in a patient following surgery, the method comprising analysis of circulating tumor DNA from a patient's sample.

Abstract: The invention is a method of predicting response to therapy in a colorectal cancer patient, the method comprising analysis of circulating tumor DNA from a patient's sample.

Abstract: The invention comprises novel methods and compositions for detecting whether a patient will be responsive to ALK inhibitors and methods of treating the patient.

Abstract: Methods and/or systems for scanning biometric objects and compiling 2-dimensional digital images thereof, such images as can provide enhanced resolution, with reduced distortion.

Abstract: Methods and/or systems for scanning biometric objects and compiling 2-dimensional digital images thereof, such images as can provide enhanced resolution, with reduced distortion.

Abstract: The invention relates to methods and reagents for diagnosing and treating diabetes.

Abstract: Sets of genetic markers for specific tumor classes are described, as well as methods of identifying a biological sample based on these markers. Genes that are differentially expressed between different stages of colorectal tumors are identified. Genes that are differentially expressed between tumors that have metastasized to the regional lymph nodes and tumors that have not metastasized to the regional lymph nodes are identified. Changes in gene expression pattern between two samples or between a sample and a control may be used to determine tumor stage. Also described are diagnostic, prognostic, and therapeutic screening uses for these markers, as well as oligonucleotide arrays comprising these markers.

Abstract: A field effect transistor (FET) having at least two independently biased gates can provide uniform electric field in the channel region of the FET. The same AC voltage may be applied to each gate for modulating the FET. One of the gates is positioned closer to the channel region than the other gate. Such a FET allows tailoring the electric field in the channel region of the FET so that it is substantially uniform. The FET exhibits desirable performance characteristics, including having a constant transconductance.

Abstract: The invention relates to methods and reagents for diagnosing and treating diabetes.

Abstract: The present invention provides a pancreatic islet transcription factor and methods of treating and diagnosing diabetes.

Abstract: The present invention provides polynucleotides encoding potassium channels as well as methods of using the potassium channels to treat and diagnose diabetes and a predisposition for diabetes.

Abstract: The invention provides arrays for analysis of compromised nucleic acid samples, for example, nucleic acids obtained from formalin fixed paraffin embedded samples and methods to analyzed these compromised samples. Arrays are disclosed in which the probe selection region used to select probes for the array is the 300 bases of the target MRNA that are immediately upstream of the start of the poly(A) tail of the mRNA. The probes selected for the array are more biased toward the 3? end of the mRNA than other arrays that are currently available.

Abstract: Many genes are affected in prostate cancers which have not been previously identified. This includes genes that have been up-regulated or down-regulated. Monitoring the expression levels of these genes is useful to identify the existence of prostate cancer. Also, monitoring the expression levels of these genes is useful to predict the effectiveness of treatment, outcome, use of therapeutics, and screening drugs useful for the treatment of prostate cancer.

Abstract: The invention relates to methods and reagents for diagnosing and treating diabetes.

Abstract: A disposable postage stamp marker is provided which consists of a frame and a device carried within the frame, for making a predetermined amount of visible impressions of small official government seals on mail to show that postage has been paid for the mail. An apparatus is carried within the frame and is coupled to the visible impressions making a device for enumerating the predetermined amount of visible impressions that can be made.