Abstract: Provided is an aerosol generating device including a battery, a first cartridge including a first material containing nicotine and a pH adjuster and a first heater configured to heat the first material, and a controller configured to control power supplied to the first heater from the battery.

Abstract: A computer that includes a processor and a memory, the memory including instructions executable by the processor to input an image to a first neural network to generate a first detected object and input the image to a second neural network to generate a reconstructed image which is input to a third neural network to generate a second detected object. The image can be divided into portions and the portions input to respective fourth neural networks to generate portions of a third detected object. The first detected object, the second detected object, the portions of the third detected object, and context data can be input to a partially observable Markov decision process to generate a high confidence detected object.

Abstract: Extended release, abuse deterrent dosage forms comprising crush-resistant controlled-release particles that provide abuse deterrent properties to the dosage forms. The crush-resistant controlled-release particles, which comprise plastic/elastic polymers and at least one active pharmaceutical ingredient (API) or a pharmaceutically acceptable salt thereof, are prepared by a hot melt extrusion process.

Abstract: In certain embodiments, an optical system for obtaining surgical information includes a probe housing a first optical fiber, a light source, a photoanalyzer, and an optical circulator optically coupled to each of the first optical fiber, the light source, and the photoanalyzer. The optical circulator has a first port configured to receive source light generated from the light source, a second port configured to transmit the source light from the first port to the first optical fiber, and a third port configured to transmit return light in the first optical fiber from the second port to the photoanalyzer. The first optical fiber is configured to emit at least a portion of the source light in the first optical fiber from the probe to contact a body structure, and collect light returning from the body structure as a result of the portion of the source light contacting the body structure.

Abstract: The present example provides a scalable tooling system using highly parallel convection heating for processing of high temperature composite materials. A single-sided mold is provided with vacuum pressure to cast and consolidate a raw material. The mold is integrally heated by a plurality of discretized heat sources providing a plurality of convection airflow sources to minimize the hot and cold spots inherit to typical convection oven processing. Airflow is arranged by orifices aligned conformally to the mold's profile surface such that rapid heating rates may be achieved while maintaining temperature control along the mold surface.

Abstract: A method of making an optical article having a gradient tint and a gradient polarization. The method includes contacting one or more dye compositions including at least one of a dichroic dye, a photochromic-dichroic dye, or any combination thereof, with an optical element having a continuous coating including at least one alignment zone. At least a portion of the dye composition diffuses into the coating at a predetermined concentration gradient along at least a portion of the coating.

Abstract: An optical article that includes an optical element and an anisotropic coating layer formed over at least a portion of the optical element. The anisotropic coating layer can include a first light-influencing zone comprising at least one first anisotropic material and a second light-influencing zone comprising at least one second anisotropic material. The at least one of the first light-influencing zone and the second light-influencing zone further include at least one dichroic material and/or at least one photochromic-dichroic material such that the first light-influencing zone and the second light-influencing zone exhibit a different color property, a different photochromic-dichroic reversible change, a different amount of polarization, or a combination thereof.

Abstract: A visualization system for an ophthalmic procedure on a target eye, e.g., lens replacement surgery, includes first and second light sources respectively operable for directing visible and NIR light toward the target eye. A hot mirror directs reflected light from the eye along two paths, i.e., a visible light path for reflected visible light and an NIR light path for reflected NIR light. First and second cameras are respectively positioned in the visible and NR light paths to detect the reflected visible or NIR light and output a visible or NIR image. An electronic control unit (ECU) executes a method to detect a perimeter edge of an imaged portion of the target eye in the NIR image using edge detection logic, merges the visible image with the NIR image to construct a combined image, and indicates the perimeter edge in the combined image.

Abstract: A surgical microscope is configured to capture images of an eye of a patient and defines an optical axis. An illumination source is configured to emit a plurality of beams onto the eye of the patient at a plurality of angles relative to the optical axis. A controller is coupled to the surgical microscope and the illumination source, the controller configured to independently control values for illumination parameters for each beam of the plurality of beams to facilitate imaging of the eye of the patient. The illumination parameters may compensate for reflections from the iris, offset of the eye relative to the optical axis, and reflections of ambient light. The illumination parameters may be controlled subject to inputs received from a surgeon or other user.

Abstract: In certain embodiments, a system, a computer-implemented method, and computer-readable medium are disclosed for enhanced ophthalmic visualization. A plurality of images corresponding to different portions of the electromagnetic spectrum are obtained and combined, such as by pixel-wise subtraction to obtain a combined image. The images may be weighted with weights selected to enhance visualization of features, such as layers of the retina or features corresponding to pathologies. The combined image may be processed, such as by a machine learning model, to extract features.

Abstract: In certain embodiments, a system, a computer-implemented method, and computer-readable medium are disclosed for performing integrated analysis of MSI and OCT images to diagnose eye disorders. MSI and OCT are processed using separate input machine learning models to create input feature maps that are input to an intermediate machine learning model. The intermediate machine learning model processes the input feature maps and outputs a final feature map that is processed by one or more output machine learning models that output one or more estimated representations of a pathology of the eye of the patient. A single device captures OCT and non-OCT images using (a) a sensor of a first imaging device that is shared with a second imaging device and/or (b) an optical component for directing light form the retina to the first imaging device or the second imaging device.

Abstract: This invention generally relates to the field of somatic gene therapy. The invention provides a nucleic acid construct comprising a transgene encoding a therapeutic protein, a tetracycline-responsive aptazyme sequence, and inverted terminal repeats (ITRs). The nucleic acid construct can be transferred to a subject in need thereof in the form of a viral vector, in particular an adeno-associated virus (AAV) vector. The Tet-responsive aptazyme sequence allows for a tightly controlled expression of the transgene in the subject, thereby avoiding toxic side effects. The nucleic acid construct and the viral vectors comprising same are particularly useful in the treatment of proliferative diseases like cancer.

Abstract: An entertainment system including a removable seat-back display unit and a docking station. The seat-back display unit can include a rotating latch butterfly release mechanism that prevents unauthorized release of the display unit from the docking station. The system can include a three-point attachment system that provides additional protection against accidental detachment of the display unit, and provide safety in the event of partial dislodging. The system can include a current control pin system that ensures that current is not provided from the docking station to the display unit until the respective connectors have been properly engaged. The system can also include a heat dissipation system that employs the docking station to share the heat dissipation load with the display unit.

Abstract: Various implementations disclosed herein include devices, systems, and methods that provide a view of a three-dimensional (3D) environment in which virtual content is presented. For example, an example process may include obtaining virtual content and positioning the virtual content within a view of a 3D environment by determining on-screen content and off-screen content, positioning the on-screen content on a virtual screen within the 3D environment, and positioning off-screen content outside of the virtual screen within the 3D environment. The method may further include presenting the view of the 3D environment including a presentation of the on-screen content on the virtual screen and the off-screen content outside of the virtual screen.

Abstract: The present technology aims at providing a novel type of drug for treating a subject suffering from an inflammatory disease. Specifically, the present technology provides polypeptides comprising at least four immunoglobulin single variable domains (ISVDs), characterized in that at least two ISVDs bind to IL-13 and at least two ISVDs binds to TSLP. The present technology also provides nucleic acids, vectors and compositions.

Abstract: A trailer-based system and related method are described for efficiently transporting, configuring and deploying a power flow control system, including connection to a power transmission line. The system may include preconfigured modules using bolted attachments, hoist rings and a corona ring structure. Standardized clamps are also used. A plurality of power flow control modules is operable while mounted on the trailer. The power flow control modules are configurable to inject reactive power into the power transmission line.

Abstract: There is disclosed a labyrinth seal arrangement for gas turboexpanders and the like which reduces process gas losses. The labyrinth seal includes a plurality of axially spaced seal sets with teeth facing a seal member. A plurality of vent ports in between each seal set permits extraction of gradually lower pressure process gas.

Abstract: A method of making an optical article having a gradient tint and a gradient polarization. The method includes providing an optical element including a coating having at least one alignment zone. A dye composition is contacted with the coating. The dye composition includes at least one of: a dichroic dye, a photochromic-dichroic dye, or a combination thereof to diffuse at least a portion of the dye composition into the coating at a predetermined concentration gradient along at least a portion of the coating to provide the gradient tint and the gradient polarization. A kit for making an optical article having a gradient tint and a gradient polarization. An optical article prepared from a method for making an optical article having a gradient tint and a gradient polarization.

Abstract: There is disclosed a labyrinth seal arrangement for gas turboexpanders and the like which reduces process gas losses. The labyrinth seal includes a plurality of axially spaced seal sets with teeth facing a seal member. A plurality of vent ports in between each seal set permits extraction of gradually lower pressure process gas.