Abstract: The present technology aims at providing a novel type of drug for treating a subject suffering from an inflammatory disease. Specifically, the present technology provides polypeptides comprising at least four immunoglobulin single variable domains (ISVDs), characterized in that at least two ISVDs bind to IL-13 and at least two ISVDs binds to TSLP. The present technology also provides nucleic acids, vectors and compositions.

Abstract: In certain embodiments, a system, a computer-implemented method, and computer-readable medium are disclosed for enhanced ophthalmic visualization. A plurality of images corresponding to different portions of the electromagnetic spectrum are obtained and combined, such as by pixel-wise subtraction to obtain a combined image. The images may be weighted with weights selected to enhance visualization of features, such as layers of the retina or features corresponding to pathologies. The combined image may be processed, such as by a machine learning model, to extract features.

Abstract: Various implementations disclosed herein include devices, systems, and methods that provide a view of a three-dimensional (3D) environment in which virtual content is presented. For example, an example process may include obtaining virtual content and positioning the virtual content within a view of a 3D environment by determining on-screen content and off-screen content, positioning the on-screen content on a virtual screen within the 3D environment, and positioning off-screen content outside of the virtual screen within the 3D environment. The method may further include presenting the view of the 3D environment including a presentation of the on-screen content on the virtual screen and the off-screen content outside of the virtual screen.

Abstract: In certain embodiments, an illumination system for a microscope includes an illumination source and a computer. The illumination source comprises light engines. The computer receives an illumination request comprising a color request and an intensity request. The color request includes color selections, where each color selection requests a color output for at least a subset of the light engines. The intensity request includes intensity selections, where each intensity selection requests an intensity output for at least a subset of the light engines. The computer determines intensity inputs according to the intensity request, where each intensity input provides an illumination instruction to a light engine. The computer determines color inputs according to the color request, where each color input provides a color instruction to a light engine. The computer generates light engine inputs from the intensity inputs and the color inputs and sends the light engine inputs to the light engines.

Abstract: A visualization system for use during an ophthalmic procedure. The system includes at least one illumination source configured to emit in a visible and an invisible light spectrum, a light filter configured to allow light within a filtered light spectrum, and an image sensor assembly configured to detect first and second sets of images from the visible and invisible light spectrums, respectively. The system also includes an electronic control unit (ECU) in communication with the at least one illumination source and the image sensor assembly. The ECU is programmed to activate the at least one illumination source to emit light in the visible and the invisible light spectrum and receive image data from the image sensor assembly representative of the first and second sets of images. The controller is also programmed to generate and display at least one composite image based on the first and second sets of images.

Abstract: The present disclosure provides a novel type of drug for treating a subject suffering from an inflammatory disease. Specifically, the disclosure provides polypeptides comprising at least three immunoglobulin single variable domains (ISVDs), characterized in that at least one ISV binds to OX40L and at least two ISVDs bind to IL-13. The present disclosure also provides nucleic acids, vectors and compositions.

Abstract: A tunable eye model includes a housing having an inner chamber and at least one aperture adjacent to an anterior portion of the inner chamber. A lens is at least partially disposed in the at least one aperture, and the lens has a variable focal length. An optical target of the tunable eye model is disposed over a posterior portion of the inner chamber. The optical target is configured to facilitate evaluation of a characteristic of an ophthalmic microscope when viewed through the lens with the ophthalmic microscope.

Abstract: The present technology aims at providing a novel type of drug for treating a subject suffering from an inflammatory disease. Specifically, the present technology provides polypeptides comprising at least four immunoglobulin single variable domains (ISVDs), characterized in that at least two ISVDs bind to IL-13 and at least two ISVDs binds to TSLP. The present technology also provides nucleic acids, vectors and compositions.

Abstract: Various implementations disclosed herein include devices, systems, and methods that provide a view of a three-dimensional (3D) environment in which virtual content is presented. For example, an example process may include obtaining virtual content and positioning the virtual content within a view of a 3D environment by determining on-screen content and off-screen content, positioning the on-screen content on a virtual screen within the 3D environment, and positioning off-screen content outside of the virtual screen within the 3D environment. The method may further include presenting the view of the 3D environment including a presentation of the on-screen content on the virtual screen and the off-screen content outside of the virtual screen.

Abstract: In certain embodiments, an ophthalmic system includes an anamorphic depth gauge (ADG) device and a computer. The ADG device measures the z-location in the interior of an eye and includes a detector array arranged at an oblique angle with respect to the z-axis. The array generates a detector signal in response to detecting a light beam, which has a z-focus in the interior of the eye. A set of line focus optical elements focuses the light beam to form a line focus on the detector array, and a set of nominal focus optical elements focuses the light beam to form a nominal focus on the detector array. The computer: generates an image using the detector signal; determines the position of the nominal focus on the line focus according to the image; and determines the z-location of the z-focus from the position of the nominal focus on the line focus.

Abstract: A visualization system for use with an ophthalmic microscope having a pair of image sensors includes a first pair and multiple second pairs of interchangeable eyepieces each having a corresponding magnification level and field-of-view (FOV), and digital binoculars in communication with the image sensors. The digital binoculars include a housing configured to connect to the ophthalmic microscope and defining a housing cavity, a pair of annular bases connected to the housing configured to separately engage the first and multiple second pairs of interchangeable eyepieces to provide the FOV, and surrounding a corresponding center axis or designated position, and a pair of micro displays positioned within the housing cavity. Each respective one of the micro displays is arranged on the corresponding center axis or designated position.

Abstract: Optical systems for forming uniform illumination are disclosed. The optical system includes a light source coupled to a plurality of first light carriers providing a plurality of light intensities and a second light carrier coupled to the plurality of first light carriers. The second light carrier spatially homogenizes the plurality of light intensities to form a homogenized light intensity. The optical system further includes an illumination module coupled to the second light carrier and operable to receive the homogenized light intensity.

Abstract: The present technology aims at providing a novel type of drug for treating a subject suffering from an inflammatory disease. Specifically, the present technology provides polypeptides comprising at least four immunoglobulin single variable domains (ISVDs), characterized in that at least two ISVDs bind to IL-13 and at least two ISVDs binds to TSLP. The present technology also provides nucleic acids, vectors and compositions.

Abstract: An illuminated contact lens system for illuminating an interior of a patient's eye includes a contact lens, an external light source, and a light engine. The lens refracts directed light into the eye. The light source emits the directed light toward the eye. The light engine transmits electronic control signals that cause the light source to emit the directed light. A prism array connected to an annular tube containing the light source may optionally shape the directed light into a conical distribution pattern. A control board may drive the light source in response to the electronic control signals, and may be optionally used as a proximity sensor. A method includes receiving the electronic control signals from the light engine via the control board, illuminating the light source, and emitting the directed light from the toward the eye.

Abstract: There is disclosed a labyrinth seal arrangement for gas turboexpanders and the like which reduces process gas losses. The labyrinth seal includes a plurality of axially spaced seal sets with teeth facing a seal member. A plurality of vent ports in between each seal set permits extraction of gradually lower pressure process gas.

Abstract: In certain embodiments, an optical system for obtaining surgical information includes a probe housing a first optical fiber, a light source, a photoanalyzer, and an optical circulator optically coupled to each of the first optical fiber, the light source, and the photoanalyzer. The optical circulator has a first port configured to receive source light generated from the light source, a second port configured to transmit the source light from the first port to the first optical fiber, and a third port configured to transmit return light in the first optical fiber from the second port to the photoanalyzer. The first optical fiber is configured to emit at least a portion of the source light in the first optical fiber from the probe to contact a body structure, and collect light returning from the body structure as a result of the portion of the source light contacting the body structure.

Abstract: The present example provides a scalable tooling system using highly parallel convection heating for processing of high temperature composite materials. A single-sided mold is provided with vacuum pressure to cast and consolidate a raw material. The mold is integrally heated by a plurality of discretized heat sources providing a plurality of convection airflow sources to minimize the hot and cold spots inherit to typical convection oven processing. Airflow is arranged by orifices aligned conformally to the mold's profile surface such that rapid heating rates may be achieved while maintaining temperature control along the mold surface.

Abstract: A visualization system for an ophthalmic procedure on a target eye, e.g., lens replacement surgery, includes first and second light sources respectively operable for directing visible and NIR light toward the target eye. A hot mirror directs reflected light from the eye along two paths, i.e., a visible light path for reflected visible light and an NIR light path for reflected NIR light. First and second cameras are respectively positioned in the visible and NR light paths to detect the reflected visible or NIR light and output a visible or NIR image. An electronic control unit (ECU) executes a method to detect a perimeter edge of an imaged portion of the target eye in the NIR image using edge detection logic, merges the visible image with the NIR image to construct a combined image, and indicates the perimeter edge in the combined image.