Abstract: The invention describes modulating the innate immune response to pathogens by the compounds comprising C35-C90 polyisoprenyls of Formula 1 and Formula 2, as well as their derivatives, as well as methods of their use, including activation and or modulation of the integrins, including those with CD11b chain. Such modulation consists of the upregulation of integrins and attenuation of pathological inflammation in a disease while sustaining the innate antiviral response via Toll-receptors. This invention is directed towards using the above as antimicrobial, immunoregulatory, anti-cancer, anti-inflammatory treatments for humans and animals, including in diseases where pathological inflammation is caused by coronaviruses (SARS-CoV-2, FIPV), herpesviruses, and other agents.