Patents by Inventor John Paul Madeley

John Paul Madeley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing modulators of p300 and/or CBP
    Patent number: 11453662
    Abstract: A process for producing a compound of the following formula (I) which process comprises: (a) treating a compound of the following formula (5) with a compound of the following formula (6) to generate an intermediate compound of the following formula (7); (b) treating a compound of formula (7) as defined above with a compound of the following formula (8); and (c) recovering a compound of formula (I) as defined above. The compound of formula (I) is a promising modulator of p300/CBP activity that has potential utility in treating cancers, including prostate cancer, haematological cancers, bladder cancer and lung cancer.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: September 27, 2022
    Assignee: CELLCENTRIC LTD
    Inventors: Paul Baguley, Donald Alan Gilbert, Gareth Harbottle, Colin Lindley, John Paul Madeley, James Vaughan Morey, David Michel Adrien Taddei, Jonathan Trevorrow, David Wood
  • PROCESS FOR PREPARING MODULATORS OF P300 AND/OR CBP
    Publication number: 20210163463
    Abstract: A process for producing a compound of the following formula (I) which process comprises: (a) treating a compound of the following formula (5) with a compound of the following formula (6) to generate an intermediate compound of the following formula (7); (b) treating a compound of formula (7) as defined above with a compound of the following formula (8); and (c) recovering a compound of formula (I) as defined above. The compound of formula (I) is a promising modulator of p300/CBP activity that has potential utility in treating cancers, including prostate cancer, haematological cancers, bladder cancer and lung cancer.
    Type: Application
    Filed: April 18, 2019
    Publication date: June 3, 2021
    Inventors: Paul BAGULEY, Donald Alan GILBERT, Gareth HARBOTTLE, Colin LINDLEY, John Paul MADELEY, James Vaughan MOREY, David Michel Adrien TADDEI, Jonathan TREVORROW, David WOOD
  • ENANTIOSELECTIVE PROCESS
    Publication number: 20090221824
    Abstract: A process for the production of compounds comprising the enantioselective hydrogenation of 2-substituted acrylic acid derivatives.
    Type: Application
    Filed: August 12, 2005
    Publication date: September 3, 2009
    Inventors: Paul Howard Briner, Matthew Colin Thor Fyfe, John Paul Madeley, Peter John Murray, Martin James Procter, Felix Spindler