Patents by Inventor John Paul Ranieri
John Paul Ranieri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110256106Abstract: A fluid matrix comprising cross-linked remodelable collagen from a donor vertebrate animal is useful for regenerating hydrodynamic function in damaged intervertebral discs in vivo. The matrix may be injectable and may comprise cells and a plurality of purified cell growth factors. The matrix promotes cell growth and elaboration of proteoglycans to facilitate regeneration of native tissues. The collagen in the matrix may be cross-linked using photooxidative catalysis and visible light, and purified cell growth factors are preferably at least partly bone-derived.Type: ApplicationFiled: August 4, 2010Publication date: October 20, 2011Inventors: Jeffrey William Moehlenbruck, John Paul Ranieri
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Publication number: 20100021439Abstract: A fluid matrix comprising cross-linked remodelable collagen from a donor vertebrate animal is useful for regenerating hydrodynamic function in damaged intervertebral discs in vivo. The matrix may be injectable and may comprise cells and a plurality of purified cell growth factors. The matrix promotes cell growth and elaboration of proteoglycans to facilitate regeneration of native tissues. The collagen in the matrix may be cross-linked using photooxidative catalysis and visible light, and purified cell growth factors are preferably at least partly bone-derived.Type: ApplicationFiled: June 2, 2009Publication date: January 28, 2010Inventors: Jeffrey William Moehlenbruck, John Paul Ranieri
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Patent number: 7556649Abstract: A fluid matrix comprising cross-linked remodelable collagen from a donor vertebrate animal is useful for regenerating hydrodynamic function in damaged intervertebral discs in vivo. The matrix may be injectable and may comprise cells and a plurality of purified cell growth factors. The matrix promotes cell growth and elaboration of proteoglycans to facilitate regeneration of native tissues. The collagen in the matrix may be cross-linked using photooxidative catalysis and visible light, and purified cell growth factors are preferably at least partly bone-derived.Type: GrantFiled: March 29, 2004Date of Patent: July 7, 2009Assignee: Zimmer Orthobiologics, Inc.Inventors: Jeffrey William Moehlenbruck, John Paul Ranieri
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Patent number: 7147846Abstract: An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The adherent cells are transfected with at least one recombinant nucleic acid molecule encoding at least one protein that enhances patency of the graft. The prosthetic graft has a long-term patency and success rate that is superior to other previously described prosthetic grafts designed for such use. Also disclosed are methods of making and using such a graft.Type: GrantFiled: March 3, 2004Date of Patent: December 12, 2006Assignee: Zimmer Orthobiologics, Inc.Inventors: Diane Lee Anderson, John Paul Ranieri, Maurizio Capogrossi Colognesi, Marco Scoccianti, Antonio Facchiano
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Publication number: 20040235170Abstract: An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The adherent cells are transfected with at least one recombinant nucleic acid molecule encoding at least one protein that enhances patency of the graft. The prosthetic graft has a long-term patency and success rate that is superior to other previously described prosthetic grafts designed for such use. Also disclosed are methods of making and using such a graft.Type: ApplicationFiled: March 3, 2004Publication date: November 25, 2004Applicant: Centerpulse Biologics Inc.Inventors: Diane Lee Anderson, John Paul Ranieri, Maurizio Capogrossi Colognesi, Marco Scoccianti, Antonio Facchiano
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Patent number: 6733747Abstract: An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The adherent cells are transfected with at least one recombinant nucleic acid molecule encoding at least one protein that enhances patency of the graft. The prosthetic graft has a long-term patency and success rate that is superior to other previously described prosthetic grafts designed for such use. Also disclosed are methods of making and using such a graft.Type: GrantFiled: October 15, 2001Date of Patent: May 11, 2004Assignee: Centerpulse Biologics Inc.Inventors: Diane Lee Anderson, John Paul Ranieri, Maurizio Capogrossi Colognesi, Marco Scoccianti, Antonio Facchiano
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Patent number: 6723335Abstract: A fluid matrix comprising cross-linked remodelable collagen from a donor vertebrate animal is useful for regenerating hydrodynamic function in damaged intervertebral discs in vivo. The matrix may be injectable and may comprise cells and a plurality of purified cell growth factors. The matrix promotes cell growth and elaboration of proteoglycans to facilitate regeneration of native tissues. The collagen in the matrix may be cross-linked using photooxidative catalysis and visible light, and purified cell growth factors are preferably at least partly bone-derived.Type: GrantFiled: April 7, 2000Date of Patent: April 20, 2004Inventors: Jeffrey William Moehlenbruck, John Paul Ranieri
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Publication number: 20020173453Abstract: Herein is disclosed a method of treating renal injury in a mammal, comprising administering to the mammal a mixture of growth factors comprising at least two selected from bone morphogenic protein-2 (BMP-2), bone morphogenic protein-3 (BMP-3), bone morphogenic protein-4 (BMP-4), bone morphogenic protein-5 (BMP-5), bone morphogenic protein-6 (BMP-6), bone morphogenic protein-7 (BMP-7), transforming growth factor &bgr; (TGF-&bgr;1, transforming growth factor &bgr; (TGF-&bgr;2, transforming growth factor &bgr;3. (TGF-&bgr;3, or fibroblast growth factor 1 (FGF-1).Type: ApplicationFiled: December 15, 2000Publication date: November 21, 2002Inventors: Rama Akella, John Paul Ranieri
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Publication number: 20020077697Abstract: The present invention is directed to various products and processes comprising segments of vasculature from long-necked birds for use as vascular grafts. Also contemplated is a process for preparing this vasculature for use as a small-bore vascular graft. The isolated vasculature of the present invention is of sufficient length to be used in a variety of applications, and may be stored for extended lengths of time after isolation or processing before implantation.Type: ApplicationFiled: December 15, 2000Publication date: June 20, 2002Inventors: John Paul Ranieri, Diane L. Hern-Anderson, Anne Marie J. Gonin, Brian Keith McIlroy
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Publication number: 20020026235Abstract: An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The adherent cells are transfected with at least one recombinant nucleic acid molecule encoding at least one protein that enhances patency of the graft. The prosthetic graft has a long-term patency and success rate that is superior to other previously described prosthetic grafts designed for such use. Also disclosed are methods of making and using such a graft.Type: ApplicationFiled: October 15, 2001Publication date: February 28, 2002Applicant: Sulzer Biologics, Inc.Inventors: Diane Lee Anderson, John Paul Ranieri, Maurizio Capogrossi Colognesi, Marci Scoccianti, Antonio Facchiano
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Patent number: 6328762Abstract: An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The adherent cells are transfected with at least one recombinant nucleic acid molecule encoding at least one protein that enhances patency of the graft. The prosthetic graft has a long-term patency and success rate that is superior to other previously described prosthetic grafts designed for such use. Also disclosed are methods of making and using such a graft.Type: GrantFiled: April 27, 1999Date of Patent: December 11, 2001Assignee: Sulzer Biologics, Inc.Inventors: Diane Lee Anderson, John Paul Ranieri, Maurizio Capogrossi Colognesi, Marco Scoccianti, Antonio Facchiano