Patents by Inventor John Pavey

John Pavey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
    Patent number: 8466284
    Abstract: The invention provides certain novel compounds as listed in the specification and pharmaceutically acceptable salts thereof and particular Forms thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: June 18, 2013
    Assignee: Astra Zeneca AB
    Inventors: David Chapman, Martin Lindsjö, Hans Lönn, Michael Lundkvist, Magnus Munck AF Rosenschöld, Antonios Nikitidis, Debra Ainge, John Pavey
  • Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
    Publication number: 20100280048
    Abstract: The invention provides certain novel 6-heteroaryl-5-methyl-3-oxo-4-[3(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide derivatives and pharmaceutically acceptable salts thereof and particular Forms thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
    Type: Application
    Filed: November 5, 2008
    Publication date: November 4, 2010
    Applicant: ASTRAZENECA R&D
    Inventors: Debra Ainge, David Chapman, Martin Lindsjo, Hans Lonn, Michael Lundkvist, Magnus Munck AF Rosen-Schold, Antonios Nikitidis, John Pavey
  • New oxabispidine compunds useful in the treatment of cardiac arrhythmias
    Publication number: 20090326221
    Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
    Type: Application
    Filed: September 1, 2009
    Publication date: December 31, 2009
    Applicant: AstraZeneca AB,
    Inventors: Annika Bjore, Magnus Bjorsne, David Cladingboel, Kurt-Jurgen Hoffman, John Pavey, Fritiof Ponten, Gert Strandlund, Peder Svensson, Colin Thomson, Michael Wilsterman
  • New process for the production of oxabispidines
    Publication number: 20090240051
    Abstract: There is provided a process for the preparation of a compound of formula I, or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R1, R2, R3, R4 and R41 to R46 have meanings given in the description, which process comprises the dehydrative cyclisation of a compound of formula II,
    Type: Application
    Filed: March 6, 2009
    Publication date: September 24, 2009
    Applicant: AstraZeneca AB
    Inventor: John Pavey
  • Novel Tricyclic Spiropiperidine Compounds, Their Synthesis and Their Uses as Modulators of Chemokine Receptor Activity
    Publication number: 20090176815
    Abstract: Compounds of formula (I) wherein R1, R3, R4, R5, R6, R7, and R10 are as defined in the specification, are described. The present invention also relates to pharmaceutical composition comprising said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof. Beside, the invention relates to salts and polymorphic forms of the new compounds as well as the preparation thereof.
    Type: Application
    Filed: January 16, 2009
    Publication date: July 9, 2009
    Inventors: Tomas Eriksson, Martin Hemmerling, Bo-Goran Josefsson, Svetlana Ivanova, Marguerite Mensonides-Harsema, John Mo, John Pavey, Austen Pimm, James Reuberson, Hakan Schulz, Per Strandberg
  • Process for the preparation of -(4-piperidinyl)--ethyl-phenylacetamides from -Boc-4-oxopiperidine
    Patent number: 7547789
    Abstract: The present invention concerns a process for the preparation of an N-(4-piperidinyl)-N-ethyl-phenylacetamide of formula (I); wherein R1 and R2 are independently selected from the group comprising: hydrogen, halogen, C1-4 alkyl, C1-4alkoxy, cyano and S(O)2(C1-4 alkyl).
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: June 16, 2009
    Assignee: Astrazeneca AB
    Inventors: Emma Anderson, John Pavey
  • New process for production of oxabispidines
    Publication number: 20090036675
    Abstract: There is provided a process for the preparation of a compound of formula I, (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R1, R2, R3, R4 and R41 to R46 have meanings given in the description, which process comprises the dehydrative cyclisation of a compound of formula II, (II).
    Type: Application
    Filed: September 15, 2008
    Publication date: February 5, 2009
    Applicant: AstraZeneca AB
    Inventor: John Pavey
  • Process for the production of oxabispidines
    Patent number: 7439355
    Abstract: There is provided a process for the preparation of a compound of formula I, (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R1, R2, R3, R4 and R41 to R46 have meanings given in the description, which process comprises the dehydrative cyclisaton of a compound of formula II. (II).
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: October 21, 2008
    Assignee: AstraZeneca AB
    Inventor: John Pavey
  • Process for the Preparation of N-(4-Piperidinyl)-N-Ethyl-Phenylacetamides from N-Boc-4-Oxopiperidine
    Publication number: 20080214824
    Abstract: The present invention concerns a process for the preparation of an N-(4-piperidinyl)-N-ethyl-phenylacetamide of formula (I); wherein R1 and R2 are independently selected from the group comprising: hydrogen, halogen, C1-4 alkyl, C1-4alkoxy, cyano and S(O)2(C1-4 alkyl).
    Type: Application
    Filed: December 14, 2005
    Publication date: September 4, 2008
    Inventors: Emma Anderson, John Pavey
  • Gas Bearing Spindles
    Publication number: 20080178795
    Abstract: A gas bearing spindle (2) for use in processing apparatus (1), for example ion implantation apparatus. The spindle (2) has a steel bearing surface (23) and a shaft (3) coated with chrome (3a) or another hard material.
    Type: Application
    Filed: April 11, 2006
    Publication date: July 31, 2008
    Inventor: Christopher John Pavey
  • Novel Compounds 243
    Publication number: 20080167332
    Abstract: Compounds of formula (I) wherein R1, R3, R4, R5, R6, R7, and R10 are as defined in the specification, are described. The present invention also relates to pharmaceutical composition comprising said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof. Beside, the invention relates to salts and polymorphic forms of the new compounds as well as the preparation thereof.
    Type: Application
    Filed: July 18, 2007
    Publication date: July 10, 2008
    Inventors: Scott Gibson, Barry Elkins, Mike Rogers, Ian Hassall, Hong Gu, Zhenyu Wang, Vinod Kumar, Synthana Suresh Kumar, Santosh Kavitake, Sidda Lingesha, Eric Merifield, David Ennis, John Pavey, Austen Pimm, James Reuberson, Bo-Goran Josefsson, Martin Hemmerling, Svetlana Ivanova, Marguerite Mensonides-Harsema, Hakan Schulz, John Mo, Tomas Eriksson, Per Strandberg
  • Novel Process 470
    Publication number: 20080081928
    Abstract: A process for preparing 2-chloro-5-(3-oxopropyl)-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide and compounds of formula (I).
    Type: Application
    Filed: September 5, 2007
    Publication date: April 3, 2008
    Applicant: AstraZeneca AB
    Inventors: David Ennis, Agnes Ford, Joel LeBars, John Pavey
  • Oxabispidine compounds useful in the treatment of cardiac arrhythmias
    Patent number: 7351821
    Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: April 1, 2008
    Assignee: AstraZeneca AB
    Inventors: Annika Björe, Magnus Björsne, David Cladingboel, Kurt-Jürgen Hoffmann, John Pavey, Fritiof Pontén, Gert Strandlund, Peder Svensson, Colin Thomson, Michael Wilsterman
  • Oxabispidine compounds useful in the treatment of cardiac arrhythmias
    Publication number: 20070117799
    Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
    Type: Application
    Filed: December 18, 2006
    Publication date: May 24, 2007
    Inventors: Annika Bjore, Magnus Bjorsne, David Cladingboel, Kurt-Jurgen Hoffmann, John Pavey, Fritiof Ponten, Gert Strandlund, Peder Svensson, Colin Thomson, Michael Wilsterman
  • Oxabispidine compounds useful in the treatment of cardiac arrhythmias
    Patent number: 7164017
    Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: January 16, 2007
    Assignee: AstraZeneca AB
    Inventors: David Cladingboel, John Pavey, Colin Thomson
  • New oxabispidine compounds useful in the treatment of cardiac arrhythmias
    Publication number: 20060166980
    Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
    Type: Application
    Filed: March 22, 2006
    Publication date: July 27, 2006
    Applicant: AstraZeneca AB
    Inventors: Annika Bjore, Magnus Bjorsne, David Cladingboel, Kurt-Jurgen Hoffmann, John Pavey, Fritiof Ponten, Gert Strandlund, Peder Svensson, Colin Thomson, Michael Wilsterman
  • Process for the production of oxabispidines
    Patent number: 6936712
    Abstract: There is provided a process for the preparation of a compound of formula I, (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R1, R2, R3, R4 and R41 to R46 have meanings given in the description, which process comprises the dehydrative cyclisaton of a compound of formula II, (II).
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: August 30, 2005
    Assignee: AstraZeneca AB
    Inventor: John Pavey
  • Process for the production of oxabispidines
    Publication number: 20050171100
    Abstract: There is provided a process for the preparation of a compound of formula I, (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R1, R2, R3, R4 and R41 to R46 have meanings given in the description, which process comprises the dehydrative cyclisaton of a compound of formula II. (II).
    Type: Application
    Filed: March 25, 2005
    Publication date: August 4, 2005
    Applicant: AstraZeneca AB
    Inventor: John Pavey
  • New oxabispidine compounds useful in the treatment of cardiac arrhythmias
    Publication number: 20030153564
    Abstract: There is provided compounds of formula I, 1
    Type: Application
    Filed: December 12, 2002
    Publication date: August 14, 2003
    Applicant: AstraZeneca AB
    Inventors: Annika Bjore, Magnus Bjorsne, David Cladingboel, Kurt-Jurgen Hoffmann, John Pavey, Fritiof Ponten, Gert Strandlund, Peder Svensson, Colin Thomson, Michael Wilsterman