Patents by Inventor John Peter Clayton

John Peter Clayton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phthalidyl ester of 3-carbomoyloxy cephalosporin derivatives
    Patent number: 4107433
    Abstract: Phthalidyl and substituted phthalidyl esters of certain cephalosporins are absorbed by the oral route into the serum, where they are hydrolyzed to the parent antibacterially active cephalosporin.
    Type: Grant
    Filed: December 29, 1976
    Date of Patent: August 15, 1978
    Assignee: Beecham Group Limited
    Inventors: Peter Hubert Bentley, John Peter Clayton
  • Intermediates for the preparation of antibacterial compounds
    Patent number: 4102904
    Abstract: A novel acid of formula: ##STR1## which is termed "monic acid" and is prepared from pseudomonic acid, is a useful intermediate for the preparation of esters thereof.
    Type: Grant
    Filed: June 6, 1977
    Date of Patent: July 25, 1978
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John Peter Clayton, Norman Harold Rogers
  • Antibacterial compounds
    Patent number: 4102901
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: June 6, 1977
    Date of Patent: July 25, 1978
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John Peter Clayton, Norman Harold Rogers
  • Phthalidyl esters of 7-[(.alpha. amino, 2 substituted acetamido)-3-(heterocyclic-thio methyl)]cephalosporins
    Patent number: 4092476
    Abstract: Phthalidyl and substituted phthalidyl esters of certain cephalosporins are absorbed by the oral route into the serum, where they are hydrolyzed to the parent antibacterially active cephalosporin.
    Type: Grant
    Filed: December 29, 1976
    Date of Patent: May 30, 1978
    Assignee: Beecham Group Limited
    Inventors: Peter Hubert Bentley, John Peter Clayton
  • Penicillins
    Patent number: 4081545
    Abstract: A class of .alpha.-(heterocyclic carbonylamino) penicillins in which the heterocyclic group of the acyl moiety is a fused bicyclic ring having a nitrogen atom at the bridge position, shows good antibacterial activity.
    Type: Grant
    Filed: October 29, 1976
    Date of Patent: March 28, 1978
    Assignee: Beecham Group Limited
    Inventor: John Peter Clayton
  • Penicillins
    Patent number: 4048320
    Abstract: A class of 6-methoxy-.alpha.-carboxy penicillins have antibacterial activity against a wide range of Gram-negative organisms.
    Type: Grant
    Filed: January 7, 1976
    Date of Patent: September 13, 1977
    Assignee: Beecham Group Limited
    Inventors: John Peter Clayton, Peter Hubert Bentley
  • Lactonyl esters of penicillins
    Patent number: 4036829
    Abstract: Lactonyl esters of Penicillins of the formula ##STR1## WHEREIN R.sup.1 is an antibacterially active penicillin-completing side chain; R is hydrogen, methyl or phenyl; and Ra, Rb, Rc, Rd are hydrogen, lower alkyl, lower alkoxy, halo, and nitro, provided that when R is hydrogen and R.sup.1 is D-.alpha.-aminophenylacetamido and Ra, Rb, Rc, and Rd are not all hydrogen are disclosed to possess antibacterial properties.
    Type: Grant
    Filed: August 5, 1976
    Date of Patent: July 19, 1977
    Assignee: Beecham Group Limited
    Inventors: Harry Ferres, John Peter Clayton
  • Organic compounds
    Patent number: 4033979
    Abstract: Intermediates useful in the preparation of compounds having a penam or cephem ring structure, particularly penicillins and cephalosporins, and their preparation.
    Type: Grant
    Filed: January 21, 1976
    Date of Patent: July 5, 1977
    Assignee: Beecham Group Limited
    Inventors: Peter Hubert Bentley, John Peter Clayton
  • 6-Isocyanato-6-substituted penicillins
    Patent number: 3996235
    Abstract: Intermediates useful in the preparation of compounds having a penam or cephem ring structure, particularly penicillins and cephalosporins, and their preparation.
    Type: Grant
    Filed: April 10, 1975
    Date of Patent: December 7, 1976
    Assignee: Beecham Group Limited
    Inventors: Peter Hubert Bentley, John Peter Clayton
  • Penicillin monoesters, their production and intermediates thereof
    Patent number: 3981866
    Abstract: Mono-esters of .alpha.-carboxypenicillins and their preparation are described including intermediates for the mono-esters. The mono-esters are esterified on the .alpha.-carboxy group. They are well absorbed orally and de-esterified in vivo to give high serum concentrations of the parent .alpha.-carboxypenicillins.
    Type: Grant
    Filed: September 21, 1973
    Date of Patent: September 21, 1976
    Assignee: Beecham Group Limited
    Inventors: John Peter Clayton, Harry Ferres
  • Phthalide penicillin ester intermediates
    Patent number: 3963702
    Abstract: The phthalide ester of 6-[D(-)a-aminophenylacetamido] penicillanic acid and intermediates therefor are described. The phthalide penicillin ester is orally administered to obtain high serum concentrations of the parent penicillin.
    Type: Grant
    Filed: March 4, 1974
    Date of Patent: June 15, 1976
    Assignee: Beecham Group Limited
    Inventors: Harry Ferres, John Peter Clayton
  • Aminoalkyl esters of penicillins
    Patent number: 3941774
    Abstract: Novel substituted amino methyl esters of penicillins and cephalosporins for oral administration which are much better absorbed than the parent compounds.
    Type: Grant
    Filed: May 21, 1973
    Date of Patent: March 2, 1976
    Assignee: Beecham Group Limited
    Inventors: John Peter Clayton, Kenneth David Hardy, Angela Wendy Capel Guest
  • Penicillin esters
    Patent number: 3939180
    Abstract: 3-CROTONOLACTONE 3-BISCROTONO-LACTANE PENICILLINS WHICH POSSESS ANTIBACTERIAL ACTIVITY ARE DISCLOSED.
    Type: Grant
    Filed: December 9, 1974
    Date of Patent: February 17, 1976
    Assignee: Beecham Group limited
    Inventors: Harry Ferres, John Peter Clayton
  • Isocyanocephalosporanates
    Patent number: 3936446
    Abstract: Intermediates useful in the preparation of compounds having a penam or cephem ring structure, particularly penicillins and cephalosporins, and their preparation.
    Type: Grant
    Filed: February 19, 1974
    Date of Patent: February 3, 1976
    Assignee: Beecham Group Limited
    Inventors: Peter Hubert Bentley, John Peter Clayton