Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: A cylinder head defines an EGR crossover tube integrally formed in the cylinder head. The EGR crossover tube includes a first end fluidly coupled to an exhaust port of an engine. A second end is fluidly coupled to an intake port of the engine. A Venturi tube configuration is positioned between the first and second ends. A first sensor port extends through the cylinder head to the EGR crossover tube. The first sensor port is positioned at a restriction of the Venturi tube configuration. A second sensor port extends through the cylinder head to the EGR crossover tube. The second sensor port is positioned proximate the first end. A differential pressure sensor includes a first pressure sensor positioned in the first sensor port and a second pressure sensor positioned in the second sensor port.

Abstract: A cylinder head defines an EGR crossover tube integrally formed in the cylinder head. The EGR crossover tube includes a first end fluidly coupled to an exhaust port of an engine. A second end is fluidly coupled to an intake port of the engine. A Venturi tube configuration is positioned between the first and second ends. A first sensor port extends through the cylinder head to the EGR crossover tube. The first sensor port is positioned at a restriction of the Venturi tube configuration. A second sensor port extends through the cylinder head to the EGR crossover tube. The second sensor port is positioned proximate the first end. A differential pressure sensor includes a first pressure sensor positioned in the first sensor port and a second pressure sensor positioned in the second sensor port.

Abstract: Various embodiments provide a method of varying engine displacement. The method includes determining a change in a stroke distance of the engine required to obtain a pre-determined volumetric change in a displacement of the engine. The method includes machining a top surface of a crankcase so as to remove a height of material from the crankcase. The height is calculated to correspond to the change in the stroke of the engine required to obtain the volumetric change in the displacement of the engine. The method also includes coupling the crankcase to an engine block portion of the engine.

Abstract: A cam rocker lever comprises an annular piece with an inner diameter, a cam lobe, a first linear portion, and a second linear portion. The cam lobe is disposed within the inner diameter of the annular piece. The first linear portion extends from a first side of the annular piece, and a second linear portion extends from a second side of the annular piece opposite the first side. The first linear portion is configured to connect to a stem of a valve such that the valve is displaced when the first linear portion is displaced.

Abstract: A cam rocker lever comprises an annular piece with an inner diameter, a cam lobe, a first linear portion, and a second linear portion. The cam lobe is disposed within the inner diameter of the annular piece. The first linear portion extends from a first side of the annular piece, and a second linear portion extends from a second side of the annular piece opposite the first side. The first linear portion is configured to connect to a stem of a valve such that the valve is displaced when the first linear portion is displaced.