Abstract: Methods and compositions for the efficient and accurate determination of HIV susceptibility to an integrase inhibitor and/or HIV replication capacity are provided. In certain aspects, the methods involve detecting in a biological sample a nucleic acid encoding an HIV integrase that comprises a primary mutation at codon 143, wherein the mutation at codon 143 does not encode arginine (R) or cysteine (C), and wherein the presence of the integrase-encoding nucleic acid in the biological sample indicates that the HIV has a decreased susceptibility to an integrase inhibitor or altered replication capacity relative to a reference HIV. In certain embodiments, the HIV also contains one or more secondary mutations in integrase. Also provided are methods for determining the selective advantage of a mutation or mutation profile based on the difficulty to create the mutation, and its effect on susceptibility to an integrase inhibitor or replication capacity.

Abstract: Methods and compositions for the efficient and accurate determination of HIV susceptibility to an integrase inhibitor and/or HIV replication capacity are provided. In certain aspects, the methods involve detecting in a biological sample a nucleic acid encoding an HIV integrase that comprises a primary mutation at codon 143, wherein the mutation at codon 143 does not encode arginine (R) or cysteine (C), and wherein the presence of the integrase-encoding nucleic acid in the biological sample indicates that the HIV has a decreased susceptibility to an integrase inhibitor or altered replication capacity relative to a reference HIV. In certain embodiments, the HIV also contains one or more secondary mutations in integrase. Also provided are methods for determining the selective advantage of a mutation or mutation profile based on the difficulty to create the mutation, and its effect on susceptibility to an integrase inhibitor or replication capacity.

Abstract: A platform for ordering search results according to result popularity a directory assistance service, itself, to determine the popularity of the listings associated with a particular category and, therefore, the order in which those listings should be delivered resulting from a category search. Priority may be determined by the popularity of each search result. For example, directory assistance users in a particular location will likely know which businesses have a reputation for providing the best service or highest-quality products. Such factors will determine the popularity of these businesses. Businesses that are more popular are likely to be selected more frequently from the category search results than those that are less popular. The system may examine the history of search results for each listing and order the results of a particular category search according to the number of historical requests for each returned listing.

Abstract: Challenges to the analysis of search results may be mitigated by offering preview information when users navigate a computer-pointing device over pre-designated areas of a search result page. A separate icon in the pre-designated area enhances the advantages by providing intuitive preview ability with seamless and natural control over a variety of preview options, such as the type of preview information and the manner in which it is presented. In addition, while operating a preview-enabled search result page, users' behavior provides data and attributes, which may be re-incorporated into the searching algorithm to improve the relevancy of search results.

Abstract: Challenges to the analysis of search results may be mitigated by offering preview information when users navigate a computer-pointing device over pre-designated areas of a search result page. A separate icon in the pre-designated area enhances the advantages by providing intuitive preview ability with seamless and natural control over a variety of preview options, such as the type of preview information and the manner in which it is presented. In addition, while operating a preview-enabled search result page, users' behavior provides data and attributes, which may be re-incorporated into the searching algorithm to improve the relevancy of search results.

Abstract: Challenges to the analysis of search results may be mitigated by offering preview information when users navigate a computer-pointing device over pre-designated areas of a search result page. A separate icon in the pre-designated area enhances the advantages by providing intuitive preview ability with seamless and natural control over a variety of preview options, such as the type of preview information and the manner in which it is presented. In addition, while operating a preview-enabled search result page, users' behavior provides data and attributes, which may be re-incorporated into the searching algorithm to improve the relevancy of search results. ng algorithm to improve the relevancy of search results.