Patents by Inventor JOHN PHILIP TITE

JOHN PHILIP TITE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110002953
    Abstract: The present invention relates to the use of a 1H-imidazo[4,5-c]quinolin-4-amine derivative as an adjuvant for use with nucleic acid vaccination.
    Type: Application
    Filed: September 15, 2010
    Publication date: January 6, 2011
    Inventors: Lindy Louise THOMSEN, John Philip Tite, Peter Topley
  • Publication number: 20090274726
    Abstract: The present invention relates to synthetic genes, processes for designing said synthetic genes and their uses in gene therapy and improved DNA vaccination. The novel synthetic genes and processes are codon shuffled so that they have reduced homology relative to a naturally occurring gene encoding the same protein without altering the overall codon usage frequency of the gene. In particular the present invention relates to improved polynucleotides and methods for the treatment or prevention of disease comprising codon-shuffled GM-CSF nucleic acid sequences. Nucleic acid vaccines of the present invention may comprise a combination of a nucleotide sequence encoding codon-shuffled GM-CSF, a nucleotide encoding an antigen against which it is desired to raise an immune response and a toll-like receptor (TLR) agonist.
    Type: Application
    Filed: September 3, 2007
    Publication date: November 5, 2009
    Inventors: Sara Jane Brett, Michael Nail Burden, Peter Franz Ertl, Paul Andrew Hamblin, John Philip Tite
  • Publication number: 20090208515
    Abstract: The present invention relates to virus vectors comprising oligonucleotides encoding HIV polypeptides, more particularly wherein the virus vector is an adenovirus. In particular, such adenoviruses are non-human primate adenoviruses such as simian adenoviruses, more particularly chimpanzee adenoviruses. In particular the invention relates to adenovirus vectors which comprise HIV polynucleotide sequences which encode multiple different HIV antigens, for example two or three or more HIV antigens. The invention further relates to methods of preparing the virus vectors, to the virus vectors produced by the methods and to the use of the vectors in medicine especially prophylactic or therapeutic vaccination.
    Type: Application
    Filed: May 10, 2006
    Publication date: August 20, 2009
    Inventors: Peter Franz Ertl, John Philip Tite, Catherine Ann Van Wely
  • Publication number: 20090203144
    Abstract: The invention provides a nucleotide sequence that encodes an HIV-1 gag protein or fragment thereof containing a gag epitope and a second HIV antigen or a fragment encoding an epitope of said second HIV antigen, operably linked to a heterologous promoter. Preferred polynucleotide sequences further encodes nef or a fragment thereof and RT or a fragment thereof.
    Type: Application
    Filed: January 17, 2008
    Publication date: August 13, 2009
    Inventors: ANDREW BEATON, PETER FRANZ ERTL, GERALD WAYNE GOUGH, ANDREW LEAR, JOHN PHILIP TITE, CATHERINE ANN VAN WELY
  • Publication number: 20090104153
    Abstract: The present invention relates to methods of eliciting an immune response by use of a prime-boost schedule for delivering a polynucleotide encoding a heterologous non-self antigen. In particular, the invention relates to a prime-boost schedule wherein the priming polynucleotide composition is delivered by an adenoviral vector, and the boosting polynucleotide composition is coated on or incorporated in a particle and is administered by a particle acceleration device.
    Type: Application
    Filed: December 20, 2006
    Publication date: April 23, 2009
    Inventors: Karen A. Barber, Gillian Margaret Baxter, Sara Jane Brett, Paul Andrew Hamblin, John Philip Tite, Olivier Vidalin
  • Publication number: 20080188469
    Abstract: The present invention relates to improvements in DNA vaccination and in particular, methods of vaccinating a mammal against disease states, and to the use of imidazo[4,5-c]quinolin-4-amine derivative adjuvants in the manufacture of medicaments for boosting previously vaccinated individuals.
    Type: Application
    Filed: January 8, 2008
    Publication date: August 7, 2008
    Inventors: Lindy Louise Thomsen, John Philip Tite
  • Publication number: 20040076633
    Abstract: The present invention relates to the use of a 1H-imidazo[4,5-c]-4-amine derivative as an adjuvant for use with nucleic acid vaccination.
    Type: Application
    Filed: September 23, 2003
    Publication date: April 22, 2004
    Inventors: Lindy Loise Thomsen, John Philip Tite, Peter Topley