Abstract: We disclose a pharmaceutical composition adapted for oral delivery comprising native testosterone; a treatment regimen comprising administration of the composition(s); and methods and uses for the treatment of hormone related conditions such as hypogonadism in human male, female and transgender subjects.

Abstract: We disclose a pharmaceutical composition adapted for oral delivery comprising native testosterone; a treatment regimen comprising administration of the composition(s); and methods and uses for the treatment of hormone related conditions such as hypogonadism in human male, female and transgender subjects.

Abstract: Devices and methods are provided for slicing an item such as a bagel. An apparatus includes an upper assembly with a blade and interior vertical rails, and a lower assembly with a holding plate, movable centering plates, and exterior vertical rails with a slot for an external cutting device. The lower assembly also includes a cam mechanism to activate the centering plates. A method involves depressing actuators to separate the centering plates, creating space for a food item. When the food item is placed on the holding plate, the actuators are released, applying equal force to center the food item. The device also includes a centering device and an actuator that, upon receiving force, engages the centering device to hold the item in a cutting position for the blade. The device cuts the item within about +/?one-sixteenth of an inch.

Abstract: A system and method of creating a lattice structure for a part formed via additive manufacturing. The method includes generating a finite element mesh including a first finite element, generating a first natural space data structure such that the first finite element includes the first natural space data structure, generating a first unit cell corresponding to the first finite element, and generating a first design space data structure such that the first unit cell includes the first design space data structure and the first natural space data structure. The method further includes modifying the first unit cell via the first design space data structure and modifying the first unit cell via the first natural space data structure to correspond to the modifications of the first unit cell in the first design space data structure.

Abstract: A multi-layer armor plate comprises a strike plate, a structural mesh layer, an outer skin, a compliant mesh layer, and an inner skin layer. The strike plate has an outer surface and an inner surface. The structural mesh layer is positioned on the outer surface of the strike plate and includes lattice structure with a first structural compliance. The outer skin layer is positioned over the structural mesh layer. The compliant mesh layer is positioned on the inner surface and includes lattice structure with a second structural compliance that is greater than the first structural compliance. The inner skin layer is positioned over the compliant mesh layer.

Abstract: A media propelling system comprises a motor for rotating a wheel assembly that is configured to propel the media and a valve assembly configured to control flow rate of the media to the wheel assembly. The valve assembly includes a media valve configured to selectively open and close to control the flow rate of the media to the wheel assembly, an actuator that actuates the media valve to open or close the media valve and thereby change the flow rate of the media, and a control valve configured to receive pressurized material and dispense the pressurized material to the actuator to thereby control operation of the actuator. A control system is in communication with the motor and the control valve and is configured to control the control valve based on a comparison of a sensed or actual amperage of the motor and a target amperage of the motor.

Abstract: A dosimetry system for monitoring radiation exposure for a device under inspection comprises a support structure, a plurality of detectors, a signal processing unit, and a computing device. The support structure includes an upper surface on which the device under inspection is positioned. The detectors are positioned in proximity to the device under inspection. Each detector is configured to detect radiation and generate a radiation electronic signal whose level varies according to an amount of radiation to which the detector is exposed. The signal processing unit is configured to receive the radiation electronic signal from each detector and output data derived from the radiation electronic signals. The computing device is configured to receive the data from the signal processing unit and determine an accumulated radiation level for each detector.

Abstract: Devices and methods are provided for slicing an item such as a bagel. One slicer has an upper assembly, which has an upper interior portion, and a blade; and a lower assembly, separable from the upper assembly, has a holding plate to support the item when placed within the lower assembly, and movable centering plates to secure the item in a position that lies substantially in the center of the lower assembly to facilitate a substantially even bisection of the item when the upper assembly engages with the lower assembly. Another slicer has an upper assembly with interior vertical rails, and a blade affixed to the upper assembly within the rails; and a lower assembly similar to the first slicer with interior vertical rails containing a vertical slot down the center for receiving a knife for slicing items. The device cuts the item within about +/?one-sixteenth of an inch.

Abstract: A vane for insertion into a slot of a wheel of a blasting assembly such that the vane propels media as the wheel is rotated includes a body radially extending between a first vane end and a second vane end, between a first flange and a second flange, and having opposing vane side surfaces. An attachment portion integral with the second flange, the attachment portion configured to be received into the slot, and the attachment portion having a first vane end retaining surface and a second vane end retaining surface that are configured to abut the wheel. The first vane end retaining surface and the second vane end retaining surface are adjacent to each other, the first vane end retaining surface is convex, and the second vane end retaining surface is concave.

Abstract: We disclose a pharmaceutical composition adapted for oral delivery comprising native testosterone; a treatment regimen comprising administration of the composition(s); and methods and uses for the treatment of hormone related conditions such as hypogonadism in human male, female and transgender subjects.

Abstract: In wire processing systems and methods, a wire channel receives a wire. One or more fluid guides flow the fluid into the wire channel to move, along the wire, a component (e.g. a solder sleeve) positioned at least partially in the wire channel and coupled to the wire. Other features are also provided.

Abstract: The present invention provides a nanoparticle comprising: a core comprising a metal and/or a semiconductor; and a plurality of ligands covalently linked to the core, wherein said ligands comprise: (i) at least one dilution ligand comprising a carbohydrate, glutathione or an ethylene glycol-containing moiety; and (ii) a ligand of the formula D-L1-Z-L2, wherein D comprises an antifolate drug or folic acid, L1 comprises a first linker portion comprising a C2-C12 glycol and/or C2-C12 alkyl chain, L2 comprises a second linker portion comprising a C2-C12 glycol and/or C2-C12 alkyl chain, wherein L1 and L2 may be the same or different, and wherein Z represents a carbonyl-containing group linking L1 and L2, and wherein L2 is coupled to said core. Also provided are pharmaceutical compositions comprising such nanoparticles, medical uses thereof and methods for producing the nanoparticles.

Abstract: A system is provided for wire processing. The wire processing system may include a wire transport, a processing station that may provide wire to the wire transport, a processing station that may move an electrical component threaded onto the wire, and a processing station that may move the electrical component to a position on the wire for further processing.

Abstract: A device for applying a compressive force to the uterus, the device comprising a contact portion for contacting the uterus and providing a compressive force thereto, and at least two elongate handles each extending from the contact portion along a respective longitudinal axis. The at least two elongate handles are configured to facilitate insertion of the device into the body and handling of the device from outside the body when inserted. At least a part of the contact portion is configured to be radially moveable relative to the longitudinal axes between a first radial position and a second radial position where the second radial position is radially outward of the first radial position.

Abstract: The present invention provides a nanoparticle comprising: a core comprising a metal and/or a semiconductor; and a plurality of ligands covalently linked to the core, wherein said ligands comprise: (i) at least one dilution ligand comprising a carbohydrate, glutathione or a polyethyleneglycol moiety; and (ii) a ligand of the formula MTX-L-, wherein MTX-L-represents methotrexate coupled to said core via a linker L. Also provided are pharmaceutical compositions of the nanoparticle, including gel formulations, and medical uses of the nanoparticle and pharmaceutical compositions, including for the treatment of an inflammatory or autoimmune disorder, such as psoriasis.

Abstract: A system is provided for wire processing. The wire processing system may include a wire transport, a processing station that may provide wire to the wire transport, a processing station that may move an electrical component threaded onto the wire, and a processing station that may move the electrical component to a position on the wire for further processing.