Abstract: Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system.

Abstract: An artificial fireplace comprising a screen and a fuel bed portion. An optical element is provided which is configured to transpose an image of one of the screen and fuel bed to create the impression of a burning fire.

Abstract: An artificial fireplace comprising a screen and a fuel bed portion. An optical element is provided which is configured to transpose an image of one of the screen and fuel bed to create the impression of a burning fire.

Abstract: A luminal prosthesis comprises a plurality of axially arranged radially expandable stent segments 22,23 having coupling parts 20,21 for coupling of the segments 22,23. The segments 22,23 are movable between a collapsed delivery configuration in which the coupling parts 20,21 of the segments are interengaged and a deployed configuration in which the coupling parts 20,21 are disengaged. The stent segments 22,23 have means to delay the disengagement of the coupling parts 20,21 until the stent segments are close to the deployed configuration. A female coupling part 20 comprises an axially extending passageway having an entrance 30 to receive a corresponding axially extending male part 21 of an adjacent stent segment. The delay means may comprise first mating parts 40,41 and second mating parts 50,51 which are axially spaced-apart along the passageway. The second mating parts 50,51 may be located at an end of the passageway remote from the entrance to delay separation.

Abstract: The present invention provides a reactor for the biological processing of fluid such as domestic or industrial waste water or the like, the reactor comprising a plurality of substantially horizontal layers of growth medium stacked one above the other, and having a colonizing biofilm thereon during use, the reactor being arranged to cause the path of flow of the fluid to reverse from one layer to the next, in order to maximize the length of the path of flow for a given footprint of the reactor.

Abstract: The present invention provides a reactor for the biological processing of fluid such as domestic or industrial waste water or the like, the reactor comprising a plurality of substantially horizontal layers of growth medium stacked one above the other, and having a colonizing biofilm thereon during use, the reactor being arranged to cause the path of flow of the fluid to reverse from one layer to the next, in order to maximize the length of the path of flow for a given footprint of the reactor.

Abstract: The invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages of a target or target library and a target-binder library, and selecting to eliminate the non-paired targets and binders. The invention also relates to antibodies that bind to complexes of target and target binders; nucleic acids encoding target and target binders peptides; and the use of sequence information inherent in the targets and target binders for target validation using in silico approaches. The invention further relates to diagnostics and therapeutics employing the disclosed target and target binder peptides or polynucletides and their use in small molecule drug discovery; diagnostic and therapeutic applications directed to cancers and similar disorders; and site directed assays for high throughput drug screening.

Abstract: The present invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages, one comprising a target or target library and the other comprising a target-binder library, and selecting to eliminate the non-paired targets and binders. Also related are complexes comprising target and target binders, as well as antibodies that bind to these complexes. Additionally, the present invention also relates to nucleic acids encoding target and target binders peptides. The invention also relates to the use of the sequence information inherent in the targets and target binders for target validation using in silico approaches. In addition, the invention also relates to diagnostics and therapeutics employing the disclosed target and target binder peptides or polynucletides and their use in small molecule drug discovery.

Abstract: Methods are disclosed for determining the activity and function of gene products based on their change to the phenotype of cells when contacted with a surrogate molecule identified through screening of a recombinant peptide library. By identifying peptides which bind gene products for which the function is not yet known, tools are provided for determining their function and obtaining drug candidates.