Abstract: The present disclosure relates to novel pore-forming toxins of Type A C. perfringens and immunogenic compositions and vaccines thereof. The present disclosure further relates to methods and uses of treating or preventing enteric disease and assays for diagnosing enteric disease.

Abstract: The present disclosure relates to a novel toxin of Type A C. perfringens and immunogenic compositions and vaccines thereof. The present disclosure further relates to methods and uses of treating or preventing enteric disease and assays for diagnosing enteric disease in mammals.

Abstract: There is provided a vaccine for controlling Clostridium perfringens in animals, and particularly necrotic enteritis in poultry. The vaccine may comprise a C. perfringens antigenic polypeptide or variant thereof, a nucleic acid encoding the C. perfringens antigenic polypeptide or variant thereof, or a recombinant cell producing the C. perfringens antigenic polypeptide or variant thereof.

Abstract: The present disclosure relates to novel pore-forming toxins of Type A C. perfringens and immunogenic compositions and vaccines thereof. The present disclosure further relates to methods and uses of treating or preventing enteric disease and assays for diagnosing enteric disease.

Abstract: The present disclosure relates to a novel toxin of Type A C. perfringens and immunogenic compositions and vaccines thereof. The present disclosure further relates to methods and uses of treating or preventing enteric disease and assays for diagnosing enteric disease in mammals.

Abstract: A method and system for automated corrective and predictive maintenance is described herein. In one embodiment, a failure notification associated with a tool is received, wherein the failure notification indicates one or more failure events for the tool. Maintenance data associated with the tool is obtained, wherein the maintenance data includes one or more maintenance events for the tool. An optimal schedule is created for the tool by merging the failure notification and the maintenance data.

Abstract: There is provided a vaccine for controlling Clostridium perfringens in animals, and particularly necrotic enteritis in poultry. The vaccine may comprise a C. perfringens antigenic polypeptide or variant thereof, a nucleic acid encoding the C. perfringens antigenic polypeptide or variant thereof, or a recombinant cell producing the C. perfringens antigenic polypeptide or variant thereof.

Abstract: There is provided a vaccine for controlling Clostridium perfringens in animals, and particularly necrotic enteritis in poultry. The vaccine may comprise a C. perfringens antigenic polypeptide or variant thereof, a nucleic acid encoding the C. perfringens antigenic polypeptide or variant thereof, or a recombinant cell producing the C. perfringens antigenic polypeptide or variant thereof.

Abstract: A method and system for automated corrective and predictive maintenance is described herein. In one embodiment, a failure notification associated with a tool is received, wherein the failure notification indicates one or more failure events for the tool. Maintenance data associated with the tool is obtained, wherein the maintenance data includes one or more maintenance events for the tool. An optimal schedule is created for the tool by merging the failure notification and the maintenance data.

Abstract: The invention relates methods of treating a patient with locally advanced or metastatic solid tumors with a combination of an inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase or PI3K) and an inhibitor of mitogen activated protein kinase (MEK) described herein.

Abstract: There is provided a vaccine for controlling Clostridium perfringens in animals, and particularly necrotic enteritis in poultry. The vaccine may comprise a C. perfringens antigenic polypeptide or variant thereof, a nucleic acid encoding the C. perfringens antigenic polypeptide or variant thereof, or a recombinant cell producing the C. perfringens antigenic polypeptide or variant thereof.

Abstract: A cable includes a filler including a plurality of points of weakness or discontinuities spaced along its length. The points of weakness or discontinuities may be evenly spaced along the length of the cable and may be formed by partially or fully cutting through the filler. The filler may be formed from a plastics material and may be shaped, in cross section, to have a number of arms to enable it to separate other components of the cable. The filler may be electrically conductive or semi-conductive to enable it to act as screen between other components of the cable.

Abstract: The invention concerns a method for rapid identification and characterization of binding partners for a target molecule, and for providing binding partners with improved binding affinity. More specifically, the invention concerns an improved tethering method for the rapid identification of at least two binding partners that bind near one another to a target molecule.

Abstract: The invention concerns a method for rapid identification and characterization of binding partners for a target molecule, and for providing binding partners with improved binding affinity. More specifically, the invention concerns an improved tethering method for the rapid identification of at least two binding partners that bind near one another to a target molecule.

Abstract: A cable includes a filler (12) including a plurality of points of weakness (13) or discontinuities spaced along its length. The points of weakness or discontinuities may be evenly spaced along the length of the cable and may be formed by partially or fully cutting through the filler. The filler may be formed from a plastics material and may be shaped, in cross section, to have a number of arms to enable it to separate other components of the cable. The filler may be electrically conducive or semi-conductive to enable it to act as screen between other components of the cable.

Abstract: The invention concerns the identification of protein kinase inhibitors that preferentially bind to the inactive conformation of a target protein kinase. The inhibitors are identified by locking the target protein kinase in an inactive conformation, and using Tethering to identify inhibitors preferentially targeting the inactive conformation.

Abstract: The invention concerns a method for rapid identification and characterization of binding partners for a target molecule, and for providing binding partners with improved binding affinity. More specifically, the invention concerns an improved tethering method for the rapid identification of at least two binding partners that bind near one another to a target molecule.

Abstract: A filament forming apparatus and cooling apparatus for and method of inducing a uniform air flow between a filament forming area beneath a bushing and the cooling apparatus are disclosed. The cooling apparatus includes an air housing extending beneath the bushing. The air housing has a top wall and side walls defining an air chamber therebetween.

Abstract: A thermal camera is mounted within a helmet and is arranged such that the optical path in free space from its output is wholly within the volume defined by the helmet and the helmet faceplate. The output iminges on a concave mirror/lens combination located below the wearer's sightline. The arrangement is particularly suitable for fire fighting and search and rescue applications.