Abstract: A computer-implemented method includes receiving one or more update requests; identifying, a set of foundational relationships for deletion from a graph database; inferring, using one or more relationship inference rules, a set of inferred relationships for deletion from the graph database; and deleting, from the graph database, the set of foundational relationships for deletion and the set of inferred relationships for deletion. Inferring the set of inferred relationships for deletion includes searching for relationships in the set of foundational relationships for deletion that match a relationship specified in a precondition of at least one of the one or more relationship inference rules; determining whether the precondition is satisfiable using at least one of the matching relationships; and, in response to the precondition being satisfiable, inferring at least one of the relationships of the set of inferred relationships for deletion using at least one of the matching relationships.

Abstract: A method of capturing a population of T-Cell receptor and/or immunoglobulin sequences with variable regions within a patient sample, the method comprising: extracting and/or preparing DNA fragments from the patient sample; ligating a nucleic acid adapter to the DNA fragments, the nucleic acid adapter suitable for recognition by a pre-selected nucleic acid probe; capturing DNA fragments existing in the patient sample using a collection of nucleic acid hybrid capture probes, wherein each capture probe is designed to hybridize to a known V gene segment and/or a J gene segment within the T cell receptor and/or immunoglobulin genomic loci.

Abstract: A method of capturing a population of T-Cell receptor and/or immunoglobulin sequences with variable regions within a patient sample, the method comprising: extracting and/or preparing DNA fragments from the patient sample; ligating a nucleic acid adapter to the DNA fragments, the nucleic acid adapter suitable for recognition by a pre-selected nucleic acid probe; capturing DNA fragments existing in the patient sample using a collection of nucleic acid hybrid capture probes, wherein each capture probe is designed to hybridize to a known V gene segment and/or a J gene segment within the T cell receptor and/or immunoglobulin genomic loci.

Abstract: A computer-implemented method includes receiving one or more update requests; identifying, a set of foundational relationships for deletion from a graph database; inferring, using one or more relationship inference rules, a set of inferred relationships for deletion from the graph database; and deleting, from the graph database, the set of foundational relationships for deletion and the set of inferred relationships for deletion. Inferring the set of inferred relationships for deletion includes searching for relationships in the set of foundational relationships for deletion that match a relationship specified in a precondition of at least one of the one or more relationship inference rules; determining whether the precondition is satisfiable using at least one of the matching relationships; and, in response to the precondition being satisfiable, inferring at least one of the relationships of the set of inferred relationships for deletion using at least one of the matching relationships.

Abstract: In an aspect, there is provided, a method of capturing a population of T-Cell receptor and/or immunoglobulin sequences with variable regions within a patient sample, said method comprising: extracting/preparing DNA fragments from the patient sample; ligating a nucleic acid adapter to the DNA fragments, the nucleic acid adapter suitable for recognition by a pre-selected nucleic acid probe; capturing DNA fragments existing in the patient sample using a collection of nucleic acid hybrid capture probes, wherein each capture probe is designed to hybridize to a known V gene segment and/or a J gene segment within the T cell receptor and/or immunoglobulin genomic loci.

Abstract: In an aspect, there is provided, a method of capturing a population of T-Cell receptor and/or immunoglobulin sequences with variable regions within a patient sample, said method comprising: extracting/preparing DNA fragments from the patient sample; ligating a nucleic acid adapter to the DNA fragments, the nucleic acid adapter suitable for recognition by a pre-selected nucleic acid probe; capturing DNA fragments existing in the patient sample using a collection of nucleic acid hybrid capture probes, wherein each capture probe is designed to hybridize to a known V gene segment and/or a J gene segment within the T cell receptor and/or immunoglobulin genomic loci.