Patents by Inventor John R. Adler
John R. Adler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240042237Abstract: Methods of treatment and treatment systems for performing radiomodulatory stereotactic radiosurgery to treat brain disorders in which target neural tissues associated with the brain disorder are sensitized to radiation by administration of a molecular substance and/or non-targeted critical structures are protected from radiation by a molecular substance, in order to treat disorders of brain circuitry. Specific embodiments disclose means for treating pain, obesity and drug addiction.Type: ApplicationFiled: July 14, 2023Publication date: February 8, 2024Applicant: Zap Surgical Systems, Inc.Inventors: John R. Adler, JR., M. Bret Schneider
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Patent number: 11745029Abstract: Methods of treatment and treatment systems for performing radiomodulatory stereotactic radiosurgery to treat brain disorders in which target neural tissues associated with the brain disorder are sensitized to radiation by administration of a molecular substance and/or non-targeted critical structures are protected from radiation by a molecular substance, in order to treat disorders of brain circuitry. Specific embodiments disclose means for treating pain, obesity and drug addiction.Type: GrantFiled: May 30, 2019Date of Patent: September 5, 2023Assignee: Zap Surgical Systems, Inc.Inventors: John R. Adler, Jr., M. Bret Schneider
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Publication number: 20230270523Abstract: Removable marker implants having fiducial markers disposed on multiple elongate members extend and splay laterally outward when deployed thereby providing improved 3D localization and tracking of a portion of the patient's body for stereotactic radiosurgery. Such an approach is particularly useful for tracking of the uterus during radiosurgery treatment of uterine fibroids. Such implants can include an outer sheath that contains the multiple elongate members during delivery into the portion of the body. The elongate members can be slidably disposed within the shaft and advanced into an expanded deployed position by advancement of an applicator shaft or rod within the sheath. Marker implant can also be integrally formed implants with flexible arms having fiducial markers thereon that can be constrained in a sheath for delivery and resiliently splay laterally outward when released from the shaft. Methods of delivery and deployment are also provided.Type: ApplicationFiled: May 8, 2023Publication date: August 31, 2023Applicant: Zap Surgical Systems, Inc.Inventors: John R. Adler, JR., M. Bret Schneider
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Patent number: 11684446Abstract: Removable marker implants having fiducial markers disposed on multiple elongate members extend and splay laterally outward when deployed thereby providing improved 3D localization and tracking of a portion of the patient's body for stereotactic radiosurgery. Such an approach is particularly useful for tracking of the uterus during radiosurgery treatment of uterine fibroids. Such implants can include an outer sheath that contains the multiple elongate members during delivery into the portion of the body. The elongate members can be slidably disposed within the shaft and advanced into an expanded deployed position by advancement of an applicator shaft or rod within the sheath. Marker implant can also be integrally formed implants with flexible arms having fiducial markers thereon that can be constrained in a sheath for delivery and resiliently splay laterally outward when released from the shaft. Methods of delivery and deployment are also provided.Type: GrantFiled: February 11, 2020Date of Patent: June 27, 2023Assignee: Zap Surgical Systems, Inc.Inventors: John R. Adler, Jr., M. Bret Schneider
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Publication number: 20220241613Abstract: Devices and methods that allow a user to elect between performing treament planning by inverse planning or to be accomplished by utilizing one or more parameters input that are typically associated with forward planning are described herein. The systems can be configured to produce a treatment plan in a single iteration upon initiation of treatment planning or in response to determining or receiving a target geometry. While the system may be used iteratively in an extensively interactive fashion, viable inverse plans can be generated with a single user interaction, such as a single click, or optionally with no click at all. Advantageously, the system can optionally allows a clinnician to add or adjust parameters or constraints, for example in another iteration, to provide additional autonomy if desired.Type: ApplicationFiled: February 1, 2022Publication date: August 4, 2022Applicant: Zap Surgical Systems, Inc.Inventors: Radhika Mohan Bodduluri, Thibaut Loysel, Achim Schweikard, John R. Adler, JR.
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Patent number: 11076776Abstract: A method for measuring skin thickness. The method includes at a first 3D point on an outer surface of a patient, exposing the first point to near infrared (NIR) energy from an NIR source. The method includes measuring reflected energy emanating near the first 3D point, or beam incident point. The method includes determining a pattern of the reflected energy based on a distance from a center of the reflected energy, wherein the center is approximated by the first 3D point. The method includes determining a skin thickness measurement based on the pattern.Type: GrantFiled: February 12, 2019Date of Patent: August 3, 2021Assignees: Varian Medical Systems Particle Therapy GmbH, Varian Medical Systems, Inc.Inventors: John R. Adler, Jr., Ralf Bruder, Floris Ernst, Achim Schweikard
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Publication number: 20200268475Abstract: Removable marker implants having fiducial markers disposed on multiple elongate members extend and splay laterally outward when deployed thereby providing improved 3D localization and tracking of a portion of the patient's body for stereotactic radiosurgery. Such an approach is particularly useful for tracking of the uterus during radiosurgery treatment of uterine fibroids. Such implants can include an outer sheath that contains the multiple elongate members during delivery into the portion of the body. The elongate members can be slidably disposed within the shaft and advanced into an expanded deployed position by advancement of an applicator shaft or rod within the sheath. Marker implant can also be integrally formed implants with flexible arms having fiducial markers thereon that can be constrained in a sheath for delivery and resiliently splay laterally outward when released from the shaft. Methods of delivery and deployment are also provided.Type: ApplicationFiled: February 11, 2020Publication date: August 27, 2020Applicant: Zap Surgical Systems, Inc.Inventors: John R. Adler, JR., M. Bret Schneider
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Patent number: 10682529Abstract: Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased.Type: GrantFiled: February 23, 2018Date of Patent: June 16, 2020Assignee: Zap Surgical Systems, Inc.Inventors: M. Bret Schneider, John R. Adler, Jr.
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Publication number: 20190366123Abstract: Methods of treatment and treatment systems for performing radiomodulatory stereotactic radiosurgery to treat brain disorders in which target neural tissues associated with the brain disorder are sensitized to radiation by administration of a molecular substance and/or non-targeted critical structures are protected from radiation by a molecular substance, in order to treat disorders of brain circuitry. Specific embodiments disclose means for treating pain, obesity and drug addiction.Type: ApplicationFiled: May 30, 2019Publication date: December 5, 2019Applicant: Zap Surgical Systems, Inc.Inventors: John R. Adler, Jr., M. Bret Schneider
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Patent number: 10449393Abstract: A radiation system includes a support, a capsule rotatably coupled to the support, a radiation source movably coupled to the capsule, wherein the radiation source is configured to provide a treatment radiation beam, and is capable of being turned on or off in response to a control signal, and a collimator located next to the radiation source, wherein the capsule defines a space for accommodating a portion of a patient, and includes a shielding material for attenuating radiation resulted from an operation of the radiation source, and wherein the shielding material is configured to limit a radiation exposure level to 5 mR/hr or less within 5 meters from an isocenter.Type: GrantFiled: April 11, 2016Date of Patent: October 22, 2019Assignee: Varian Medical Systems, Inc.Inventors: John R. Adler, Jr., David H. Whittum, Steven W. Prince, James E. Clayton
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Publication number: 20190246954Abstract: A method for measuring skin thickness. The method includes at a first 3D point on an outer surface of a patient, exposing the first point to near infrared (NIR) energy from an NIR source. The method includes measuring reflected energy emanating near the first 3D point, or beam incident point. The method includes determining a pattern of the reflected energy based on a distance from a center of the reflected energy, wherein the center is approximated by the first 3D point. The method includes determining a skin thickness measurement based on the pattern.Type: ApplicationFiled: February 12, 2019Publication date: August 15, 2019Inventors: John R. ADLER, JR., Ralf BRUDER, Floris ERNST, Achim SCHWEIKARD
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Patent number: 10201291Abstract: A method for measuring skin thickness. The method includes at a first 3D point on an outer surface of a patient, exposing the first point to near infrared (NIR) energy from an NIR source. The method includes measuring reflected energy emanating near the first 3D point, or beam incident point. The method includes determining a pattern of the reflected energy based on a distance from a center of the reflected energy, wherein the center is approximated by the first 3D point. The method includes determining a skin thickness measurement based on the pattern.Type: GrantFiled: September 27, 2013Date of Patent: February 12, 2019Assignees: Varian Medical Systems, Inc., Varian Medical Systems Particle Therapy GMBHInventors: John R. Adler, Jr., Ralf Bruder, Floris Ernst, Achim Schweikard
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Publication number: 20180178042Abstract: Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased.Type: ApplicationFiled: February 23, 2018Publication date: June 28, 2018Inventors: M. Bret Schneider, John R. Adler, JR.
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Patent number: 9808651Abstract: Medical systems, devices, and methods provide improved radiosurgical techniques for treatment of anxiety disorders (such as Post-Traumatic Stress Disorder (PTSD), Generalized Anxiety Disorder (GAD), Panic Disorder, Social Phobia, Specific Phobia, and the like). Radiation can be directed from a radiation source outside the patient toward a target tissue deep within the patient's brain using a stereotactic radiosurgical platform, typically without having to impose the surgical trauma associated with accessing deep brain tissues. The target will often include at least a portion of the amygdala, with exemplary treatments being directed to targets that are limited to a sub-region of the amygdala. Rather than applying sufficient radiation to kill the neural tissue within the target, a cellularly sub-lethal dose of the radiation may be applied.Type: GrantFiled: May 22, 2013Date of Patent: November 7, 2017Inventors: M. Bret Schneider, John R. Adler, Jr.
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Patent number: 9757593Abstract: A radiation system includes: a first support; a first structure rotatably coupled to the first support so that the first structure is rotatable about a first axis relative to the first support; a second structure rotatably coupled to the first structure so that the second structure is rotatable about a second axis that forms a non-zero angle relative to the first structure; and a first radiation source connected to the second structure; wherein the first structure and the second structure are parts of a capsule for accommodating at least a portion of a patient.Type: GrantFiled: September 4, 2013Date of Patent: September 12, 2017Assignee: Varian Medical Systems, Inc.Inventors: John R. Adler, David H. Whittum, Steven W. Prince, James E. Clayton
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Publication number: 20170128744Abstract: A method of compensating for breathing and other motions of a patient during treatment includes periodically generating internal positional data about an internal target region. The method further includes generating external positional data about external motion of the patient's body using an external sensor and generating a correlation between one or more positions of the internal target region and one or more positions of an external region using the external positional data of the external sensor and the internal positional data of the internal target region. The method further includes predicting the position of the internal target region at some later time based on the correlation model.Type: ApplicationFiled: January 23, 2017Publication date: May 11, 2017Inventors: John R. Adler, Achim Schweikard
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Patent number: 9572997Abstract: A method of compensating for breathing and other motions of a patient during treatment includes periodically generating internal positional data about an internal target region. The method further includes generating external positional data about external motion of the patient's body using an external sensor and generating a correlation between one or more positions of the internal target region and one or more positions of an external region using the external positional data of the external sensor and the internal positional data of the internal target region. The method further includes predicting the position of the internal target region at some later time based on the correlation model.Type: GrantFiled: December 18, 2013Date of Patent: February 21, 2017Assignee: Accuray IncorporatedInventors: John R. Adler, Achim Schweikard
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Publication number: 20170043188Abstract: Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased.Type: ApplicationFiled: August 16, 2016Publication date: February 16, 2017Inventors: M. Bret Schneider, Doyle John Borchers, III, John R. Adler
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Patent number: D900838Type: GrantFiled: February 13, 2018Date of Patent: November 3, 2020Assignee: Zap Surgical Systems, Inc.Inventors: Radhika Mohan Bodduluri, Bernadette Seijo, John R. Adler, Jr., Ben Chen, Hongwu Wang, Jin-Wu Wang, Dezhi Liu, Cheng-Chieh Tsai, Yun-Yi Ting, Yan-Ling Liu, Ya-Shan Lin
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Patent number: D928820Type: GrantFiled: October 29, 2019Date of Patent: August 24, 2021Assignee: Zap Surgical Systems, Inc.Inventors: Radhika Mohan Bodduluri, Bernadette Seijo, John R. Adler, Jr., Ben Chen, Hongwu Wang, Jin-Wu Wang, Dezhi Liu, Cheng-Chieh Tsai, Yun-Yi Ting, Ya-Shan Lin, Yan-Ling Liu