Patents by Inventor John R. Chapman
John R. Chapman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120128552Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.Type: ApplicationFiled: January 24, 2012Publication date: May 24, 2012Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
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Publication number: 20120122649Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.Type: ApplicationFiled: January 26, 2012Publication date: May 17, 2012Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
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Patent number: 8177072Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.Type: GrantFiled: December 4, 2008Date of Patent: May 15, 2012Assignee: ThermoGenesis Corp.Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
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Patent number: 8167139Abstract: The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.Type: GrantFiled: July 6, 2007Date of Patent: May 1, 2012Assignee: ThermoGenesis Corp.Inventors: Philip H. Coelho, Bruce A. Baker, John R. Chapman, Junzhi Li, Prince Emmanuel, Robert S. Childers
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Publication number: 20120065048Abstract: The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.Type: ApplicationFiled: August 19, 2011Publication date: March 15, 2012Inventors: John R. Chapman, Rodney Sparks, Philip H. Coelho
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Publication number: 20120065047Abstract: The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.Type: ApplicationFiled: August 19, 2011Publication date: March 15, 2012Inventors: John R. Chapman, Rodney Sparks, Philip H. Coelho
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Publication number: 20100140182Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.Type: ApplicationFiled: December 4, 2008Publication date: June 10, 2010Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Philip D. Kingsley
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Patent number: 6596179Abstract: Apparatus for withdrawing whole blood from a donor, separating the whole blood to obtain a target cell population and returning a selected one of either the target cell population or at least a portion of the whole blood remainder to the donor or patient. A disposable separation inset for use in association with a rotatable separation device of the apparatus may also be provided. The disposable inset may include a chamber for receiving a cell suspension that includes the target cell, a receptacle for containing particles having a binding site for selectively binding to the target cell and a means for introducing the particles into the chamber.Type: GrantFiled: February 16, 2001Date of Patent: July 22, 2003Assignee: Baxter International Inc.Inventors: Richard Giesler, John R. Chapman, Dale R. Ellis, Daniel F. Bischof
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Publication number: 20010009757Abstract: A method combining the techniques of immunoaffinity separation and continuous flow centrifugal separation is provided for selective separation of a nucleated heterogeneous cell population from a heterogeneous cell mixture. The heterogeneous cell mixture is intimately contacted to promote binding thereto by particles having attached a substance that actively binds to a specific desired type of cell out of the cell mixture. The particles are selected so that the sedimentation velocity of the particle/cell conjugate differs sufficiently from those of other cells in the cell mixture to allow its separation by means of a continuous flow cell separator.Type: ApplicationFiled: February 16, 2001Publication date: July 26, 2001Inventors: Daniel F. Bischof, Richard Giesler, John R. Chapman, Dale R. Ellis
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Patent number: 6221315Abstract: Apparatus for separating a biological component from a biological fluid are disclosed. The apparatus includes a chamber for receiving a biological fluid including a biological component, and a rotor for creating a centrifugal field within the chamber. A source of particles may be included wherein the particles have a binding site for selectively binding to the biological component. The particles may be aseptically introduced into the chamber. The apparatus may withdraw whole blood from a donor, separate the whole blood to obtain a target cell population and return a selected one of either the target cell population or at least a portion of the whole blood remainder to the donor or patient. A disposable separation inset for use in conjunction with a rotatable separation device such as the apparatus described above may also be provided.Type: GrantFiled: April 12, 1999Date of Patent: April 24, 2001Assignee: Baxter International Inc.Inventors: Richard Giesler, John R. Chapman, Dale R. Ellis, Daniel F. Bischof
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Patent number: 6190609Abstract: Apparatus and methods for treating a biological fluid with light and for inactivating contaminants in biological fluid. The biological fluid is contacted with a light source providing a high intensity light to the biological fluid. The biological fluid may include a quantity of a photochemical agent that when activated by light is operable to cause inactivation of at least some of the contaminants.Type: GrantFiled: May 18, 1998Date of Patent: February 20, 2001Assignee: Baxter International Inc.Inventors: John R. Chapman, Peter R. H. Stark, Michael V. Swallow, Dale N. Larson
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Patent number: 5976884Abstract: Systems and methods treat biological fluids carrying contaminants by photoactivating materials mixed with the fluids. The systems and methods quantify the photoreactions that occur in a manner that permits correlation with clinical results.Type: GrantFiled: December 29, 1998Date of Patent: November 2, 1999Assignee: Baxter International Inc.Inventors: John R. Chapman, Jean M Mathias
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Patent number: 5948385Abstract: An antimicrobial material incorporated with a molecular halogen is provided. The antimicrobial material includes a plastic material and a molecular halogen entrapped within the plastic material. A directional release material is also provided in the present application. The directional release material allows for the control of the rate and site of halogen release. Still further, method of impregnating a plastic material are also provided.Type: GrantFiled: September 30, 1997Date of Patent: September 7, 1999Assignee: Baxter International Inc.Inventors: John R. Chapman, Ying-Cheng Lo, Winnie Kubey, Clifford J. Holmes, David Bell
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Patent number: 5922278Abstract: Apparatus and methods for treating a biological fluid with light and for inactivating contaminants in biological fluid. The biological fluid is contacted with a light source providing a high intensity light to the biological fluid. The biological fluid may include a quantity of a photochemical agent that when activated by light is operable to cause inactivation of at least some of the contaminants.Type: GrantFiled: November 19, 1996Date of Patent: July 13, 1999Assignee: Baxter International Inc.Inventors: John R. Chapman, Peter R. H. Stark, Michael A. Reed, Dale N. Larson, Daniel F. Cuffaro
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Patent number: 5916743Abstract: A method combining the techniques of immunoaffinity separation and continuous flow centrifugal separation is provided for selective separation of a nucleated heterogeneous cell population from a heterogeneous cell mixture. The heterogeneous cell mixture is intimately contacted to promote binding thereto by particles having attached a substance that actively binds to a specific desired type of cell out of the cell mixture. The particles are selected so that the sedimentation velocity of the particle/cell conjugate differs sufficiently from those of other cells in the cell mixture to allow its separation by means of a continuous flow cell separator.Type: GrantFiled: June 6, 1995Date of Patent: June 29, 1999Assignee: Baxter International Inc.Inventors: William C. Lake, Richard Giesler, Dennis Van Epps, John R. Chapman, Jeffrey A. Martinson, Dale R. Ellis, Frederick Aono, Daniel F. Bischof
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Patent number: 5866074Abstract: A vessel holds a liquid content for exposure to prescribed light energy. The vessel has a region transparent to the prescribed light energy. The liquid content of the vessel includes a solution comprising a material undergoing reduction oxidation as a result of exposure to the prescribed light energy, and a reducing agent for the photoactive material. A device measures optical absorbance of the vessel and the liquid content. The device operates in a first instance to measure a first optical absorbance value before exposing the vessel and the liquid content to the prescribed light energy. The device also operates in a second instance to measure a second optical absorbance value after exposing the vessel and the liquid content to the prescribed light energy, to obtain a difference between the first and second optical absorbance values. The difference comprises an illumination characteristic for the vessel with respect to the prescribed light energy.Type: GrantFiled: December 20, 1996Date of Patent: February 2, 1999Assignee: Baxter International Inc.Inventors: John R. Chapman, Jean M. Mathias
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Patent number: 5765615Abstract: A canter capable of curve-cutting featuring rotary, power-driven frustro-conical chipper heads for chipping a workpiece, which chipper heads are adjustable under the influence of movement structure to achieve five degrees of freedom of motion and adjustment which take into account the different topographical characteristics of different workpieces.Type: GrantFiled: September 20, 1996Date of Patent: June 16, 1998Assignee: Optimil Machinery, Inc.Inventors: John R. Chapman, Ernie R. Buchacher
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Patent number: 5663045Abstract: The present invention provides a method for testing a blood unit for viral contamination without rendering the blood unit unusable for therapeutic applications. The method comprises the steps of: removing and collecting from a blood unit a majority of the leukocytes present therein; and using the collected leukocytes to test the blood unit for viral contamination. The present invention also provides a method for validating viral inactivation processes.Type: GrantFiled: June 1, 1995Date of Patent: September 2, 1997Assignee: Baxter International Inc.Inventor: John R. Chapman
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Patent number: 5641622Abstract: A method combining the techniques of immunoaffinity separation and continuous flow centrifugal separation is provided for selective separation of a nucleated heterogeneous cell population from a heterogeneous cell mixture. The heterogeneous cell mixture is intimately contacted to promote binding thereto by particles having attached a substance that actively binds to a specific desired type of cell out of the cell mixture. The particles are selected so that the sedimentation velocity of the particle/cell conjugate differs sufficiently from those of other cells in the cell mixture to allow its separation by means of a continuous flow cell separator.Type: GrantFiled: June 7, 1994Date of Patent: June 24, 1997Assignee: Baxter International Inc.Inventors: William C. Lake, Richard Giesler, Dennis Van Epps, John R. Chapman, Jeffrey A. Martinson, Dale R. Ellis, Frederick Aono, Daniel F. Bischof
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Patent number: 5498520Abstract: The present invention provides a method for testing a blood unit for viral contamination without rendering the blood unit unusable for therapeutic applications. The method comprises the steps of: removing and collecting from a blood unit a majority of the leukocytes present therein with a leukocyte filter; and using the leukocytes collected in and on the filter to test the blood unit for viral contamination. The present invention also provides a method for validating viral inactivation processes.Type: GrantFiled: March 24, 1993Date of Patent: March 12, 1996Assignee: Baxter International Inc.Inventor: John R. Chapman