Patents by Inventor John R. Coombe

John R. Coombe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MK2 inhibitors, the synthesis thereof, and intermediates thereto
    Patent number: 12049470
    Abstract: The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.
    Type: Grant
    Filed: January 28, 2022
    Date of Patent: July 30, 2024
    Assignee: Celgene Corporation
    Inventors: Alexander L. Ruchelman, John R. Coombs, Keming Zhu, Daniel Lim, Candice Lee Joe, David T. George, Bin Zheng, Dong Lin
  • MK2 INHIBITORS, THE SYNTHESIS THEREOF, AND INTERMEDIATES THERETO
    Publication number: 20220259222
    Abstract: The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.
    Type: Application
    Filed: January 28, 2022
    Publication date: August 18, 2022
    Inventors: Alexander L. Ruchelman, John R. Coombs, Keming Zhu, Daniel Lim, Candice Lee Joe, David T. George, Bin Zheng, Dong Lin
  • Reduction of radioactive emissions from nuclear-reactor plant
    Patent number: 4187146
    Abstract: Radioactive emissions by reason of primary-liquid-to-secondary-liquid leakage in the steam generator of pressurized water reactor power plants are reduced by a demineralizer in the discharge from the blowdown tank and also by transmitting blowdown venting vapor to the condenser. For major failures resulting in power blackout an auxiliary turbine is provided. This turbine is connected to be energized by vapor (steam) by-passed from the main steam line. The auxiliary turbine drives the pumps which pump the cooling water for the condenser. The steam which drives the auxiliary turbine is also discharged to the condenser. The condensed water flows back into the steam generators where it is discharged through the blowdown tank.
    Type: Grant
    Filed: October 13, 1977
    Date of Patent: February 5, 1980
    Assignee: Westinghouse Electric Corp.
    Inventors: Ti-Ke Shen, John R. Coombe