Abstract: A mass spectrometer (MS) that is adapted to allow rapid gas-phase hydrogen/deuterium exchange (HDX) labeling of ions in one or more traveling wave ion guides (TWIGs) with or without ion mobility separation. The addition of isotopic labeling by gas-phase HDX offers a sensitive alternative dimension for conformational detection, which enables high resolution detection of gaseous conformations based on shape and surface reactivity. Gas-phase, isotopic HDX labeling or “curtain” labeling, can be performed by infusing a reactive, isotopic labeling gas, e.g., ND3, into one or more of the traveling-ion wave guides (TWIG) in the MS. Analyte ions retained in the potential wells of a traveling wave generated by one or more of the TWIGs can be isotopic labeled at adjustable gas pressures. Labeling times can also be controlled by adjusting the speed of the traveling wave and can be performed within milliseconds of ionizations, probing protein conformations present in solution.

Abstract: A mass spectrometer (MS) that is adapted to allow rapid gas-phase hydrogen/deuterium exchange (HDX) labeling of ions in one or more traveling wave ion guides (TWIGs) with or without ion mobility separation. The addition of isotopic labeling by gas-phase HDX offers a sensitive alternative dimension for conformational detection, which enables high resolution detection of gaseous conformations based on shape and surface reactivity. Gas-phase, isotopic HDX labeling or “curtain” labeling, can be performed by infusing a reactive, isotopic labeling gas, e.g., ND3, into one or more of the traveling-ion wave guides (TWIG) in the MS. Analyte ions retained in the potential wells of a traveling wave generated by one or more of the TWIGs can be isotopic labeled at adjustable gas pressures. Labeling times can also be controlled by adjusting the speed of the traveling wave and can be performed within milliseconds of ionizations, probing protein conformations present in solution.

Abstract: An insert in a compact disc or laser disc case has a slot in the edge of the tray, through which a spring loaded clip protrudes. When a disc is inserted into the case the clip will be pushed against the low tension of a spring attached to the clip. When the clip is moved by the insertion of a disc a bright colored flag appears in a window in the case. When the disc is removed, the spring moves the flag so it is not visible, indicating that the case is empty.

Abstract: A hydraulic exercise device including an elongated base having first and second ends and a standard projecting upwardly from the first end of the base having a first end of a horizontal bench pivotally supported therefrom for oscillation about a horizontal transverse axis. The second end of the bench is disposed over the second end of the base and supported therefrom by generally vertical legs including upper and lower portions pivotally anchored to the bench and base, respectively. A lever has one thereof pivotally supported from the standard above the first end of the bench and the second end of the lever projects toward the second end of the base. A double acting hydraulic cylinder has one end connected to the second end of the lever and the other end connected to the standard at a point spaced vertically therealong from the first end of the lever.