Abstract: This disclosure describes example techniques and systems for identifying the presence and/or composition of nucleic acids in the blood of a host organism of a model species harboring tissue of a donor organism of another species. For example, the technique may involve identifying the presence and composition of nucleic acids in the blood of a mouse harboring tissue of a human or another companion animal. These cell-free nucleic acids that are identified can be used as biomarkers to determine the presence of a disease, its biological behavior, its rate of progression, and/or the response of the disease to one or more unique therapies. In other examples, the cell-free nucleic acids may be used as biomarkers to determine a response of the host species to the tissue of the donor organism or a response of tissue derived from the second organism to transplantation within the first organism of the first species.

Abstract: This disclosure describes example techniques and systems for identifying the presence and/or composition of nucleic acids in the blood of a host organism of a model species harboring tissue of a donor organism of another species. For example, the technique may involve identifying the presence and composition of nucleic acids in the blood of a mouse harboring tissue of a human or another companion animal. These cell-free nucleic acids that are identified can be used as biomarkers to determine the presence of a disease, its biological behavior, its rate of progression, and/or the response of the disease to one or more unique therapies. In other examples, the cell-free nucleic acids may be used as biomarkers to determine a response of the host species to the tissue of the donor organism or a response of tissue derived from the second organism to transplantation within the first organism of the first species.

Abstract: This disclosure describes example techniques and systems for identifying the presence and/or composition of nucleic acids in the blood of a host organism of a model species harboring tissue of a donor organism of another species. For example, the technique may involve identifying the presence and composition of nucleic acids in the blood of a mouse harboring tissue of a human or another companion animal. These cell-free nucleic acids that are identified can be used as biomarkers to determine the presence of a disease, its biological behavior, its rate of progression, and/or the response of the disease to one or more unique therapies. In other examples, the cell-free nucleic acids may be used as biomarkers to determine a response of the host species to the tissue of the donor organism or a response of tissue derived from the second organism to transplantation within the first organism of the first species.

Abstract: Large, complex pedigrees of animals and plants group individuals for improved visualization. A computer transforms data from each mating to display nodes having separate symbols only for groups of offspring having common sex and/or traits. Pedigrees can include complex breeding structures. Input parameters select particular individuals, grouping, and formatting, including visual properties such as colors for distinguishing various aspects of a pedigree. Layout includes curved as well as straight lines.

Abstract: A method based on direct and indirect counting is disclosed for rapid and accurate linkage analysis for codominant and dominant loci. Methods for estimating gender-specific recombination frequencies are available for cases where at least one of the two loci is multi-allelic and for bi-allelic loci with mixed parental linkage phases where at least one locus is codominant. The method makes use of the full data set, yields exact estimates of the recombination frequencies when the observed and expected genotypic frequencies are equal, and are computationally efficient.

Abstract: Large, complex pedigrees of animals and plants group individuals for improved visualization. A computer transforms data from each mating to display nodes having separate symbols only for groups of offspring having common sex and/or traits. Pedigrees can include complex breeding structures. Input parameters select particular individuals, grouping, and formatting, including visual properties such as colors for distinguishing various aspects of a pedigree. Layout includes curved as well as straight lines.