Patents by Inventor John R. J. Sorenson
John R. J. Sorenson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8916712Abstract: The present invention provides compositions and methods for cytoprotection. In particular, it provides zinc chelate compositions comprising at least one zinc ion and at least one aminothiol ligand.Type: GrantFiled: February 6, 2014Date of Patent: December 23, 2014Assignee: The Board of Trustees of the University of ArkansasInventors: Alexei G. Basnakian, Richard B. Walker, John R. J. Sorenson
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Patent number: 8685951Abstract: The present invention provides compositions and methods for cytoprotection. In particular, it provides zinc chelate compositions comprising at least one zinc ion and at least one aminothiol ligand.Type: GrantFiled: March 26, 2008Date of Patent: April 1, 2014Assignee: The Board of Trustees of the University of ArkansasInventors: Alexei G. Basnakian, Richard B. Walker, John R. J. Sorenson deceased, Anne S. Martin
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Publication number: 20090042850Abstract: The present invention provides compositions and methods for cytoprotection. In particular, it provides zinc chelate compositions comprising at least one zinc ion and at least one aminothiol ligand.Type: ApplicationFiled: March 26, 2008Publication date: February 12, 2009Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASInventors: Alexei G. Basnakian, Richard B. Walker, John R.J. Sorenson, Anne Martin
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Patent number: 6306846Abstract: Disclosed herein are anti-inflammatory and anti-ulcer copper coordination compounds and a process for using them in the treatment of arthritis and gastrointestinal ulcers in animal bodies. The copper coordination compounds utilized are the reaction products of copper salts with: 1. aromatic carboxylic acids or their alkaline earth salts; 2. heterocyclic carboxylic acids or their alkaline earth salts; 3. amino acids or their alkaline earth salts; 4. amines; and 5. suitably substituted steroids. The process disclosed comprises administering to experimental animals, orally or parentrally (subcutaneously), in controlled dosages, the aforementioned copper coordination compounds for the treatment of inflammation (i.e., arthritis) and ulcers of the gastrointestinal tract.Type: GrantFiled: June 7, 1995Date of Patent: October 23, 2001Inventor: John R. J. Sorenson
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Patent number: 5541174Abstract: Disclosed herein are analgesic copper coordination compounds and a process for using them in the treatment of analgesia in animal bodies. The copper coordination compounds utilized are the reaction products of copper salts with:1. carboxylic acids or their alkaline earth salts;2. aromatic carboxylic acids or their alkaline earth salts;3. heterocyclic carboxylic acids or their alkaline earth salts;4. amino acids or their alkaline earth salts;5. anthranilic acids or their alkaline earth salts;6. salicylic acids or their alkaline earth salts;7. acetylsalicylates or their alkaline earth salts;8. arylacetic acids or their alkaline earth salts;9. disubstituted aminodithiocarbamates, and mixtures of any of the above.The process disclosed comprises administering to animals, orally or parenterally, in controlled dosages, the aforementioned copper coordination compounds.Type: GrantFiled: January 18, 1995Date of Patent: July 30, 1996Inventor: John R. J. Sorenson
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Patent number: 5521171Abstract: Disclosed herein are anti-inflammatory and anti-ulcer copper coordination compounds and a process for using them in the treatment of arthritis and gastrointestinal ulcers in animal bodies. The copper coordination compounds utilized are the reaction products of copper salts with:1. aromatic carboxylic acids or their alkaline earth salts;2. heterocyclic carboxylic acids or their alkaline earth salts;3. amino acids or their alkaline earth salts;4. amines; and5. suitably substituted steroids.The process disclosed comprises administering to experimental animals, orally or parentrally (subcutaneously), in controlled dosages, the aforementioned copper coordination compounds for the treatment of inflammation (i.e., arthritis) and ulcers of the gastrointestinal tract.Type: GrantFiled: March 24, 1995Date of Patent: May 28, 1996Inventor: John R. J. Sorenson
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Patent number: 5216021Abstract: Disclosed herein are analgesic copper coordination compounds and a process for using them in the treatment of analgesia in animal bodies. The copper coordination compounds utilized are the reaction products of copper salts with:1. carboxylic acids or their alkaline earth salts;2. aromatic carboxylic acids or their alkaline earth salts;3. heterocyclic carboxylic acids or their alkaline earth salts;4. amino acids or their alkaline earth salts;5. anthranilic acids or their alkaline earth salts;6. salicylic acids or their alkaline earth salts;7. acetylsalicylates or their alkaline earth salts;8. arylacetic acids or their alkaline earth salts;9. disubstituted aminodithiocarbamates, and mixtures of any of the above.The process disclosed comprises administering to animals, orally or parenterally, in controlled dosages, the aforementioned copper coordination compounds.Type: GrantFiled: March 4, 1991Date of Patent: June 1, 1993Inventor: John R. J. Sorenson
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Patent number: 4999347Abstract: Disclosed herein are analgesic copper coordination compounds and a process for using them in the treatment of analgesia in animal bodies. The copper coordination compounds utilized are the reaction products of copper salts with:1. carboxylic acids or their alkaline earth salts;2. aromatic carboxylic acids or their alkaline earth salts;3. heterocyclic carboxylic acids or their alkaline earth salts;4. amino acids or their alkaline earth salts;5. anthranilic acids or their alkaline earth salts;6. salicyclic acids or their alkaline earth salts;7. acetylsalicylates or their alkaline earth salts;8. arylacetic acids or their alkaline earth salts;9. disubstituted aminodithiocarbamates, and mixtures of any of the above.The process disclosed comprises administering to animals, orally or parenterally, in controlled dosages, the aforementioned copper coordination compounds.Type: GrantFiled: October 20, 1989Date of Patent: March 12, 1991Inventor: John R. J. Sorenson
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Patent number: 4952607Abstract: The present invention relates to copper complexes exhibiting superoxide dismutase-like activity in mammalian cells. The copper complexes, which act as superoxide radical (O.sub.2.sup.-) scavengers, are used in treating cancer by replacing the lost superoxide dismutase activity which characterizes tumor systems. The low molecular weight and lipid solubility of the copper complexes facilitate penetration of cell membranes. Depending upon the specific type of copper complex used, treatment may result in decreased tumor growth, increased survival of the host organism, decreased tumor metastasis or induced morphological differentiation of cancerous cells. The copper complexes used according to the invention include copper salicylate complexes, their solvates as well as mixtures thereof. A method for the treatment of cancer using these copper complexes is also disclosed.Type: GrantFiled: January 30, 1986Date of Patent: August 28, 1990Assignee: International Copper Research Association, Inc.Inventors: John R. J. Sorenson, Larry W. Oberley
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Patent number: 4758555Abstract: Copper-dependent enzymes are required for normal brain development and function. Copper deficiency can result in pathological disorders accompanied by convulsive seizures or tremors in man and animals. The present invention is directed to a method for treating convulsions or epilepsy comprising administration of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity. Those compounds include copper complexes of carboxylic acids, acylsalicylates, salicylates, amino acids, imines and known anticonvulsant and antiepileptic drugs.Type: GrantFiled: December 8, 1986Date of Patent: July 19, 1988Assignee: International Copper Research AssociationInventor: John R. J. Sorenson
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Patent number: 4758554Abstract: Copper-dependent enzymes are required for normal brain development and function. Copper deficiency can result in pathological disorders accompanied by convulsive seizures or tremors in man and animals. The present invention is directed to a method for treating convulsions or epilepsy comprising administration of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity. Those compounds include copper complexes of carboxylic acids, acylsalicylates, salicylates, amino acids, imines and known anticonvulsant and antiepileptic drugs.Type: GrantFiled: December 8, 1986Date of Patent: July 19, 1988Assignee: International Copper Research AssociationInventor: John R. J. Sorenson
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Patent number: 4757059Abstract: Copper-dependent enzymes are required for normal brain development and function. Copper deficiency can result in pathological disorders accompanied by convulsive seizures or tremors in man and animals. The present invention is directed to a method for treating convulsions or epilepsy comprising administration of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity. These compounds include copper complexes of carboxylic acids, acylsalicylates, salicylates, amino acids, imines and known anticonvulsant and antiepileptic drugs.Type: GrantFiled: December 8, 1986Date of Patent: July 12, 1988Assignee: International Copper Research AssociationInventor: John R. J. Sorenson
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Patent number: 4670428Abstract: Copper-dependent enzymes are required for normal brain development and function. Copper deficiency can result in pathological disorders accompanied by convulsive seizures or tremors in man and animals. The present invention is directed to a method for treating convulsions or epilepsy comprising administration of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity. Those compounds include copper complexes of carboxylic acids, acylsalicylates, salicylates, amino acids, imines and known anticonvulsant and antiepileptic drugs.Type: GrantFiled: August 14, 1984Date of Patent: June 2, 1987Assignee: International Copper Research Association, Inc.Inventor: John R. J. Sorenson
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Patent number: 4657928Abstract: Methods are described for using organic copper complexes or their solvates, which exhibit superoxide dismutase activity and act as superoxide radical scavengers, as radioprotectants to protect mammalian cells from damage caused by gamma- or x-irradiation. Treatment can result in the protection of normal tissues in cancer patients undergoing radiotherapy and in the protection of individuals who may be at risk with regard to hazardous effects of exposure to occupational or environmental ionizing radiation.Type: GrantFiled: September 25, 1984Date of Patent: April 14, 1987Assignee: International Copper Research Association, Inc.Inventor: John R. J. Sorenson
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Patent number: 4440754Abstract: Disclosed herein are anti-inflammatory and anti-ulcer copper coordination compounds and a process for using them in the treatment of arthritis and gastrointestinal ulcers in animal bodies. The copper coordination compounds utilized are the reaction products of copper salts with:1. aromatic carboxylic acids or their alkaline earth salts;2. heterocyclic carboxylic acids or their alkaline earth salts;3. amino acids or their alkaline earth salts;4. amines; and5. suitably substituted steroids.The process disclosed comprises administering to experimental animals, orally or parentrally (subcutaneously), in controlled dosages, the aforementioned copper coordination compounds for the treatment of inflammation (i.e., arthritis) and ulcers of the gastrointestinal tract.Type: GrantFiled: May 23, 1980Date of Patent: April 3, 1984Inventor: John R. J. Sorenson
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Patent number: 4221785Abstract: Disclosed herein are anti-inflammatory and anti-ulcer copper coordination compounds and a process for using them in the treatment of arthritis and gastrointestinal ulcers in animal bodies. The copper coordination compounds utilized are the reaction products of copper salts with:1. aromatic carboxylic acids or their alkaline earth salts;2. heterocyclic carboxylic acids or their alkaline earth salts;3. amino acids or their alkaline earth salts;4. amines; and5. suitably substituted steroids.The process disclosed comprises administering to experimental animals, orally or parentrally (subcutaneously), in controlled dosages, the aforementioned copper coordination compounds for the treatment of inflammation (i.e., arthritis) and ulcers of the gastrointestinal tract.Type: GrantFiled: May 30, 1978Date of Patent: September 9, 1980Inventor: John R. J. Sorenson