Abstract: A mechanical instrumental accessory for liquid handling (FIG. 1A) that can be manually operated or automated (FIG. 1C). Probe spacing distances are not limited as in fixed instruments (FIG. 100). FIG. 7B show a view of the automatic macro MPX™ with a replaceable cam plate (63) that slides up and down a pin adaptor (56) and can be made to move the probes to less than 4.5 mm probe-to-probe for special applications. The MPX™ liquid handling accessory (FIG. 1A) expands and contracts spacing for liquid transfer probes, needles, or tubing to have variable or equal spacing control of the adjacent probes. The interface assembly of the MPX™ liquid handling accessory (FIG. 5) allows a variety of attached sizes of liquid delivery tips and probe types. Cams (62) (FIG. 10A) are replaceable to allow for changes in application requirements.