Abstract: An injector is provided to deliver microquantities of viscous materials into the body, such as the eye, for surgical purposes. The injector comprises a syringe body with a plunger disposed therein coupled to a positive displacement mechanism capable of progressively advancing the plunger to precisely deliver microquantities of materials at a constant or predetermined delivery rate.

Abstract: The invention provides tools, materials and related methods to surgically access the suprachoroidal space of an eye for the purpose of performing minimally invasive surgery or to deliver drugs to the eye. The invention provides a flexible microcannula or microcatheter device (11, 13) that may be placed into the suprachoroidal space (12, 14) through a small incision (12A) of the overlying tissues, maneuvered into the appropriate region of the space, and then activated to treat tissues adjacent to the distal tip of the device.

Abstract: A low profile wearable infusion device comprises a generally cylindrical reservoir having a diameter greater than its height and a drive that causes a piston to move an incremental distance within the reservoir to cause the device to dispense a dose of medicament.

Abstract: A wearable infusion device comprises a component that causes a piston to move an incremental distance to cause the device to dispense a dose of medicament from a reservoir.

Abstract: An apparatus is provided for forming a tissue tract (8, 11A, 17A) from within a first passageway of an eye (11, 17) connecting to a second passageway in the eye (12, 16) comprising an elongated tool with a proximal end and distal end. The tool has an outer diameter in the range of about 50 to about 1000 microns.

Abstract: Apparatus and method is provided for capturing centrifugally-liberated liquid from a gas stream including separator components installed in a cyclonic vessel. A plurality of concentric shells supported on a base form annular cavities arranged about a gas outlet for capturing separated liquids from a spinning gas stream. The shells can be suspended from an insert manufactured with or retrofit to a vessel. Helical vanes aid in maintaining the spinning gas stream. In low moisture conditions, liquid removal through annular cavities can be supplemented with an annular layer of packing adjacent the vessel wall.

Abstract: Apparatus and method is provided for capturing centrifugally-liberated liquid from a gas stream including separator components installed in a cyclonic vessel. A plurality of concentric shells supported on a base form annular cavities arranged about a gas outlet for capturing separated liquids from a spinning gas stream. The shells can be suspended from an insert manufactured with or retrofit to a vessel. Helical vanes aid in maintaining the spinning gas stream. In low moisture conditions, liquid removal through annular cavities can be supplemented with an annular layer of packing adjacent the vessel wall.

Abstract: A method for inhibiting hyperplasia at an anastomotic junction of a vascular fistula or vascular graft comprises exposing the anastomotic junction to vibrational energy at a mechanical index and for a time sufficient to inhibit hyperplasia. Kits are described comprising the catheter or a probe suitable for performing the methods together with instructions for use setting forth the methods. The methods and kits are particularly suitable for treating anastomotic junctions formed to provide vascular access for hemodialysis, hemofiltration, and the like. The methods and kits are also suitable for treating other vascular grafts, such as those formed during cardiac bypass graft surgery, vascular repair, and the like.

Abstract: A wide beam ultrasound delivery system providing a uniform exposure field is used to enhance the uptake of injected substances and/or to enhance the transfection of DNA in the tissues of human subject, or reduce the amount of vascular intimal hyperplasia in human subjects following vascular injury.

Abstract: A method of treating a target region in a body lumen, said method comprising: directing a uniform dose of ultrasonic energy from an interior of the lumen radially outward over a treatment length of the lumen, wherein the dosage of ultrasonic energy received at any one point along the length varies by no more than plus or minus 6 decibels from that received at any other point along the length.

Abstract: A method for inhibiting hyperplasia at an anastomotic junction of a vascular fistula or vascular graft comprises exposing the anastomotic junction to vibrational energy at a mechanical index and for a time sufficient to inhibit hyperplasia. Kits are described comprising the catheter or a probe suitable for performing the methods together with instructions for use setting forth the methods. The methods and kits are particularly suitable for treating anastomotic junctions formed to provide vascular access for hemodialysis, hemofiltration, and the like. The methods and kits are also suitable for treating other vascular grafts, such as those formed during cardiac bypass graft surgery, vascular repair, and the like.

Abstract: A method for inhibiting hyperplasia at an anastomotic junction of a vascular fistula or vascular graft comprises exposing the anastomotic junction to vibrational energy at a mechanical index and for a time sufficient to inhibit hyperplasia. Kits are described comprising the catheter or a probe suitable for performing the methods together with instructions for use setting forth the methods. The methods and kits are particularly suitable for treating anastomotic junctions formed to provide vascular access for hemodialysis, hemofiltration, and the like. The methods and kits are also suitable for treating other vascular grafts, such as those formed during cardiac bypass graft surgery, vascular repair, and the like.

Abstract: A method of treating a target region in a body lumen, said method comprising: directing a uniform dose of ultrasonic energy from an interior of the lumen radially outward over a treatment length of the lumen, wherein the dosage of ultrasonic energy received at any one point along the length varies by no more than plus or minus 6 decibels from that received at any other point along the length.

Abstract: A method of treating a target region in a body lumen, said method comprising: directing a uniform dose of ultrasonic energy from an interior of the lumen radially outward over a treatment length of the lumen, wherein the dosage of ultrasonic energy received at any one point along the length varies by no more than plus or minus 6 decibels from that received at any other point along the length.

Abstract: The claimed invention provides an improved tracking tip for use with a work element in a catheter system having a flexible tubular catheter body. Use of a tracking tip according to the present invention will facilitate advancement of the work element within the catheter body and will substantially eliminate the possibility that the work element will puncture the catheter body. Preferred embodiments will comprise a wire coil and will often include a rounded end member, which may be in the form of a solder ball, at the distal tip of the wire coil. In some embodiments, the rounded end member may be coated with a lubricant or a suitable non-stick material to further improve tracking of the work element within the catheter body.

Abstract: The present invention provides improvement usable with an intravascular catheter having a single common distal lumen with a reduced profile connected to two or more proximal lumens. The catheter will be loadable over a guidewire into a region of interest within a patient's vascular system. According to one aspect of the present invention, means are provided to ensure that the guidewire enters into a desired one of the proximal lumens. In a preferred embodiment, a special tool is provided to achieve this. According to a second aspect of the present invention, the catheter is provided with a proximal housing and an axially expandable member to shield the rotating parts at the proximal end of the catheter and to allow for convenient movement of a work element within the catheter body.

Abstract: A catheter comprises a flexible tubular member having a drive cable disposed in a lumen thereof. A work element is secured to a distal end of the lumen while a coupling member for rotating the cable secured to the proximal end thereof. The cable includes a more flexible end located within the distal region of the catheter and a less flexible section located within the proximal region of the catheter. In this way, the drive cable is able to transmit torque sufficiently from the proximal end to the distal end even when the catheter is subject to tortuous twisting and bending as a result of positioning within confined regions of the body, such as the vascular system.

Abstract: Intravascular catheters including both a flexible catheter body and a less flexible housing mounted at a distal end of the catheter body are provided with a flexible distal tip, preferably having a conical geometry. Guidewire channel or lumen is formed within the tip, and optionally additional guidewire lumens are formed in the housing or the distal end of the catheter body, or both. The catheters may thus be inserted and withdrawn over a guidewire without the need for the entire length of the catheter to pass over the guidewire.