Patents by Inventor John R. Ogez

John R. Ogez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of insulin-like growth factor
    Patent number: 5446024
    Abstract: A process for purifying IGF-I from variants of IGF-I is provided. In this process a mixture containing IGF-I and its variants is loaded onto a reversed-phase liquid chromatography column and the IGF-I is eluted from the column with a buffer at a pH of about 6-8. The buffer contains an alcoholic or polar aprotic solvent at a concentration of about 20-30% (v/v). This process can be preceded by a hydrophobic-interaction chromatography step.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: August 29, 1995
    Assignee: Genentech, Inc.
    Inventors: Stuart E. Builder, John R. Ogez, Charles V. Olson, David Reifsnyder
  • Method of purifying recombinant proteins from corresponding host cell proteins
    Patent number: 5411864
    Abstract: A method for purifying a recombinant protein, e.g. human tissue plasminogen activator (t-PA) from a corresponding endogenous protein of the host cell, e.g. Chinese hamster t-PA, is disclosed. The method comprises contacting a fluid containing the recombinant protein with antibodies specifically binding the corresponding endogenous protein. Monoclonal antibodies directed against and an assay for Chinese hamster t-PA are also disclosed.
    Type: Grant
    Filed: November 5, 1987
    Date of Patent: May 2, 1995
    Assignee: Genentech, Inc.
    Inventors: Vincent R. Anicetti, Stuart E. Builder, Billie J. Marks, John R. Ogez, Eric J. Patzer, David A. Vetterlein
  • Purification and activity assurance of precipitated heterologous proteins
    Patent number: 4620948
    Abstract: A process for isolating and purifying refractile proteins from host cell culture including treating the host cell culture with a buffered solution to solubilize host protein, leaving refractile protein insoluble, treating the insoluble fraction with a strongly denaturing solution containing a reducing agent to solubilize the refractile protein, and renaturing the refractile protein.
    Type: Grant
    Filed: June 1, 1984
    Date of Patent: November 4, 1986
    Assignee: Genentech, Inc.
    Inventors: Stuart E. Builder, John R. Ogez
  • Purification and activity assurance of precipitated heterologous proteins
    Patent number: 4511502
    Abstract: A process for purifying heterologous proteins from higher molecular weight components, including dissolving the heterologous protein in a strong denaturing solution and removing the higher molecular weight components using a molecular sieve or high speed centrifugation.
    Type: Grant
    Filed: June 1, 1984
    Date of Patent: April 16, 1985
    Assignee: Genentech, Inc.
    Inventors: Stuart E. Builder, John R. Ogez