Patents by Inventor John R. Perfect

John R. Perfect has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MOLECULAR PREDICTORS OF FUNGAL INFECTION
    Publication number: 20160194715
    Abstract: Methods for identifying fungal infection, assays for identifying genomic and protein markers of fungal infection, and methods for diagnosing the fungal infection. In one aspect, the method of identifying fungal infection by proteomic assay involves measuring the protein levels of proteins listed in Table 2A in a peripheral blood cell sample and comparing the determined protein levels to standard protein levels. In another aspect, subjects identified as being infected with fungal infection are treated with anti-fungals.
    Type: Application
    Filed: December 28, 2015
    Publication date: July 7, 2016
    Inventors: Aimee K. Zaas, Geoffrey S. Ginsburg, Joseph Lucas, Hamza Aziz, John R. Perfect
  • MOLECULAR PREDICTORS OF FUNGAL INFECTION
    Publication number: 20120077767
    Abstract: Methods for identifying fungal infection, assays for identifying genomic and protein markers of fungal infection, and methods for diagnosing the fungal infection. In one aspect, the method of identifying fungal infection by proteomic assay involves measuring the protein levels of proteins listed in Table 2A in a peripheral blood cell sample and comparing the determined protein levels to standard protein levels. In another aspect, subjects identified as being infected with fungal infection are treated with anti-fungals.
    Type: Application
    Filed: May 26, 2010
    Publication date: March 29, 2012
    Inventors: Aimee K. Zaas, Geoffrey S. Ginsburg, Joseph Lucas, Hamza Aziz, John R. Perfect
  • Synthesis and antimicrobial activity of novel dicationic “reversed amidines”
    Patent number: 7745456
    Abstract: The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R5 is H, alkyl or aryl; R6 is H, alkyl, aryl, or NR7R8, in which R7 and R8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR9, in which R9 is H or alkyl, and to the use of such compounds.
    Type: Grant
    Filed: July 9, 2007
    Date of Patent: June 29, 2010
    Assignees: The University of North Carolina at Chapel Hill, Duke University, Georgia State University Research Foundation, Inc.
    Inventors: David W. Boykin, Richard R. Tidwell, W. David Wilson, John R. Perfect, Chad F. Stephens
  • Synthesis and antimicrobial activity of novel dicationic “reversed amidines”
    Patent number: 7241795
    Abstract: The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino]aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R5 is H, alkyl or aryl; R6 is H, alkyl, aryl, or NR7R8, in which R7 and R8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR9, in which R9 is H or alkyl, and to the use of such compounds.
    Type: Grant
    Filed: March 2, 2004
    Date of Patent: July 10, 2007
    Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc., Duke University
    Inventors: David W. Boykin, Richard R. Tidwell, W. David Wilson, John R. Perfect, Chad F. Stephens
  • Synthesis and antimicrobial activity of novel dicationic "reversed amidines"
    Publication number: 20040235927
    Abstract: The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino]aminophenyl}furans and thiophenes of the general formula 1
    Type: Application
    Filed: March 2, 2004
    Publication date: November 25, 2004
    Inventors: David W. Boykin, Richard R. Tidwell, W. David Wilson, John R. Perfect, Chad F. Stephens
  • Synthesis and antimicrobial activity of novel dicationic “reversed amidines”
    Patent number: 6737440
    Abstract: The present invention relates to novel 2,5-bis {[alkyl(or aryl)imino]aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R5 is H, alkyl or aryl; R6 is H, alkyl, aryl, or NR7R8, in which R7 and R8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR9, in which R9 is H or alkyl, and to the use of such compounds.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: May 18, 2004
    Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc., Duke University
    Inventors: David W. Boykin, Richard R. Tidwell, W. David Wilson, John R. Perfect, Chad F. Stephens
  • Synthesis and antimicrobial activity of novel dicationic"reversed amidines"
    Publication number: 20030083362
    Abstract: The present invention relates to novel 2,5-bis {[alkyl (or aryl) imino] aminophenyl} furans and thiophenes of the general formula 1
    Type: Application
    Filed: November 6, 2001
    Publication date: May 1, 2003
    Inventors: David W. Boykin, Richard R. Tidwell, W. David Wilson, John R. Perfect, Chad F. Stephens
  • Antifungal activity of dicationic molecules
    Patent number: 6326395
    Abstract: Methods of treating fungal infections comprise administering a therapeutically effective amount of a compound described by Formulas [(I)-(VI)]. Examples of fungal infections include Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Fusarium solani, and combinations thereof.
    Type: Grant
    Filed: September 15, 1999
    Date of Patent: December 4, 2001
    Assignees: Duke University, University of North Carolina-Chapel Hill, Georgia State University Research Found, Inc.
    Inventors: Richard R. Tidwell, David W. Boykin, John R. Perfect