Abstract: The present disclosure relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods using such ADCs, and methods for making such ADCs.

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: A method of slowing the progression of myopia in a person, comprises applying to the eye of the person a contact lens or lenses to mold the surface of the cornea. On removal of the lens, the shape of the corneal surface includes a vision correction area for correcting the myopic vision of the person, and a myopic defocus area having a more positive power and located within the pupil area, to simultaneously present a controlled myopic defocus to the retina both when viewing in the distance and also when viewing at near, without the lens in place on the cornea. Contact lenses and their use are also claimed.

Abstract: A method of slowing the progression of myopia in a person, comprises applying to the eye of the person a contact lens or lenses to mould the surface of the cornea. On removal of the lens, the shape of the corneal surface includes a vision correction area for correcting the myopic vision of the person, and a myopic defocus area having a more positive power and located within the pupil area, to simultaneously present a controlled myopic defocus to the retina both when viewing in the distance and also when viewing at near, without the lens in place on the cornea. Contact lenses and their use are also claimed.

Abstract: A method of slowing the progression of myopia in a person, comprises applying to the eye of the person contact lens or lenses each including a vision correction area for correcting in use the myopic vision of a wearer, and a myopic defocus area having a less negative focal power, to simultaneously present a controlled myopic defocus to the retina both when viewing in the distance and also when viewing at near. Contact lenses and their use are also claimed.

Abstract: A method of slowing the progression of myopia in a person, comprises applying to the eye of the person contact lens or lenses each including a vision correction area for correcting in use the myopic vision of a wearer, and a myopic defocus area having a less negative focal power, to simultaneously present a controlled myopic defocus to the retina both when viewing in the distance and also when viewing at near. Contact lenses and their use are also claimed.

Abstract: Contact lenses and methods for preventing or slowing progression of myopia are described. The contact lenses include a vision correction area and a myopic defocus area. Various examples of the contact lenses are described. Methods include providing the present contact lenses, or applying one or more of the contact lenses to an eye or eyes of a person. The contact lenses and methods are particularly useful in children.

Abstract: A method of slowing the progression of myopia in a person, comprises applying to the eye of the person contact lens or lenses each including a vision correction area for correcting in use the myopic vision of a wearer, and a myopic defocus area having a less negative focal power, to simultaneously present a controlled myopic defocus to the retina both when viewing in the distance and also when viewing at near. Contact lenses and their use are also claimed.

Abstract: A method and system for receiving payment for postage by a delivery system operator from a customer is provided. The method includes receiving payment from the customer for a first postage value; receiving the parcel for delivery, the parcel including a machine-readable postage indicia indicating the amount of the received payment; determining parcel attributes; calculating a determined postage value for the parcel based on the determined parcel attributes; determining the first postage value from the indicia; and transmitting a postage payment adjustment amount based on a comparison between the first postage value and the determined postage value.

Abstract: Contact lenses and methods for preventing or slowing progression of myopia are described. The contact lenses include a vision correction area and a myopic defocus area. Various examples of the contact lenses are described. Methods include providing the present contact lenses, or applying one or more of the contact lenses to an eye or eyes of a person. The contact lenses and methods are particularly useful in children.

Abstract: A method and system for receiving payment for postage by a delivery system operator from a customer is provided. The method includes receiving payment from the customer for a first postage value; receiving the parcel for delivery, the parcel including a machine-readable postage indicia indicating the amount of the received payment; determining parcel attributes; calculating a determined postage value for the parcel based on the determined parcel attributes; determining the first postage value from the indicia; and transmitting a postage payment adjustment amount based on a comparison between the first postage value and the determined postage value.

Abstract: A detector head for in situ inspection of irradiated nuclear fuel assemblies submerged in a water-filled nuclear fuel storage pond. The detector head includes two parallel arms which extend from a housing and which are spaced apart so as to be positionable on opposite sides of a submerged fuel assembly. Each arm includes an ionization chamber and two fission chambers. One fission chamber in each arm is enclosed in a cadmium shield and the other fission chamber is unshielded. The ratio of the outputs of the shielded and unshielded fission chambers is used to determine the boron content of the pond water. Correcting for the boron content, the neutron flux and gamma ray intensity are then used to verify the declared exposure, cooling time and fissile material content of the irradiated fuel assembly.

Abstract: A process for condensing exhaust vapor comprises alternating modes of operation. In the first mode, the exhaust vapor contacts solid particles at a first temperature below the condensation temperature of the vapor and, simultaneously, solid particles at a second temperature above the first temperature are cooled to the first temperature. In the second mode, the exhaust vapor contacts the solid particles that were cooled in the first mode and, simultaneously, solid particles that were heated in the first mode are cooled to the first temperature. This cycle repeats continuously.

Abstract: Aqueous saline solutions are converted in part to potable water by passing a compressed aqueous saline solution through one or more beds of contained pellets of higher temperature to heat the aqueous solution to a flash vaporization temperature, then passing the solution to one or more flash vaporization zones. Vaporized potable water from each vaporization zone is separately passed to contained bed of pellets where water is condensed and pellets heated. Simultaneously, a bed of pelletized solids is heated to supplant the highest temperature bed in the system used for heating. By selective switching of beds, the system is kept in continuous operation with a heated bed of pellets replacing the highest temperature bed previously used to heat the aqueous saline solution. The bed used for water condensation is transferred to the heating cycle for subsequent introduction to the system.