Patents by Inventor John R. Potoski
John R. Potoski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7714130Abstract: Methods of making Gonadotropin Releasing Hormone (“GnRH”) (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists, comprising reacting a compound having Formula I: with a compound having formula Lg—(CR13R14)k—D, are disclosed.Type: GrantFiled: June 16, 2005Date of Patent: May 11, 2010Assignee: WyethInventors: Alexander V. Gontcharov, Gulnaz Khafizova, John R. Potoski, Donna Mary Huryn
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Publication number: 20080146645Abstract: Processes are disclosed for preparing indolinone phenylaminopropanol derivatives, particularly chiral indolinone phenylaminopropanol derivatives of the general formula: The processes disclosed may be used to prepare, inter alia, 7-fluoro-1-[(1S, 2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one and 7-fluoro-1-[(1S, 2R)-1-(3,5-difluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one. Intermediates of the processes are also disclosed.Type: ApplicationFiled: August 22, 2007Publication date: June 19, 2008Applicant: WyethInventors: Anita Wai-Yin Chan, Zhixian Ding, Mousumi Ghosh, Mahmut Levent, Panolil Raveendranath, Jianxin Ren, Maotang Zhou, Asaf Alimardanov, Alexander V. Gontcharov, Antonia A. Nikitenko, John R. Potoski, Girija Raveendranath, Vijay Raveendranath, Sanjay Raveendranath
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Patent number: 6960686Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4?,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2?-disulfonic acid and its pharmaceutically acceptable salts.Type: GrantFiled: September 22, 2004Date of Patent: November 1, 2005Assignee: WyethInventors: Silvio Iera, Christopher A. Demerson, Jacqueline F. Lunetta, Maria Papamichelakis, Michael F. MacEwan, Wayne G. McMahon, John R. Potoski, Arthur G. Mohan, Antonia Nikitenko
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Patent number: 6806366Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.Type: GrantFiled: January 31, 2002Date of Patent: October 19, 2004Assignee: WyethInventors: Silvio Iera, Christopher A. Demerson, Jacqueline F. Lunetta, Maria Papamichelakis, Michael F. MacEwan, Wayne G. McMahon, John R. Potoski, Arthur G. Mohan
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Publication number: 20020151548Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.Type: ApplicationFiled: January 31, 2002Publication date: October 17, 2002Applicant: American Home Products CorporationInventors: Silvio Iera, Christopher A. Demerson, Jacqueline F. Lunetta, Maria Papamichelakis, Michael F. MacEwan, Wayne G. McMahon, John R. Potoski, Arthur G. Mohan
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Patent number: 6268504Abstract: The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: wherein: R1 and R2 are, independently, selected from H; C1-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R3, R4, R5, and R6 are independently selected from H, halogen, —NO2, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, —CN, —O—R1, —O—Ar, —S—R1, —S—Ar, —SO—R1, —SO—Ar, —SO2—R1, —SO2—Ar, —CO—R1, —CO—Ar, —CO2—R1, or —CO2—Ar; and Y is selected from a) the moiety: wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturatedType: GrantFiled: December 10, 1999Date of Patent: July 31, 2001Assignee: American Home Products CorporationInventors: Panolil Raveendranath, Joseph Zeldis, Galina Vid, John R. Potoski, Jianxin Ren, Silvio Iera
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Patent number: 6242605Abstract: The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: wherein: R1 and R2 are, independently, selected from H; C1-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is 0 or S; m is an integer from 1 to 3, preferably 2; R3, R4, R5, and R6 are independently selected from H, halogen, —NO2, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, —CN, —O—R1, —O—Ar, —S—R1, —S—Ar, —SO—R1, —SO—Ar, —SO2—R1, —SO2—Ar, —CO—R1, —CO—Ar, —CO2—R1, or —CO2—Ar; and Y is selected from a) the moiety: wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturatedType: GrantFiled: December 10, 1999Date of Patent: June 5, 2001Assignee: American Home Products CorporationInventors: Panolil Raveendranath, Joseph Zeldis, Galina Vid, John R. Potoski, Jianxin Ren, Silvio Iera
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Patent number: 6005102Abstract: The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are, independently, selected from H; C.sub.1 -C.sub.12 alkyl or C.sub.1 -C.sub.6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are independently selected from H, halogen, --NO.sub.2, alkyl, alkoxy, C.sub.1 -C.sub.6 perfluorinated alkyl, OH or the C.sub.1 -C.sub.4 esters or alkyl ethers thereof, --CN, --O--R.sup.1, --O--Ar, --S--R.sup.1, --S--Ar, --SO--R.sup.1, --SO--Ar, --SO.sub.2 --R.sup.1, --SO.sub.2 --Ar, --CO--R.sup.1, --CO--Ar, --CO.sub.2 --R.sup.1, or --CO.sub.2 --Ar; and Y is selected from a) the moiety: ##STR2## wherein R.sub.7 and R.sub.8 are independently selected from the group of H, C.sub.1 -C.sub.Type: GrantFiled: September 28, 1998Date of Patent: December 21, 1999Assignee: American Home Products CorporationInventors: Panolil Raveendranath, Joseph Zeldis, Galina Vid, John R. Potoski, Jianxin Ren, Silvio Iera
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Patent number: 4526977Abstract: 7-[2-(3-Amino-5-isoxazolyl)-2-alkyloxyiminoacetamido]-ceph-3-em-4-carboxyli c acid derivatives are antibacterial agents effective against gram-positive and gram-negative bacterium.Type: GrantFiled: April 7, 1983Date of Patent: July 2, 1985Assignee: American Home Products CorporationInventors: Thomas J. Commons, John R. Potoski
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Patent number: 4461901Abstract: Compounds of the formula: ##STR1## wherein X is SO.sub.2, SO or S; andA is an amine selected from the group: ##STR2## wherein R is hydrogen, (lower)alkyl, (lower)alkoxy or halo; n is 2-4; andthe pharmacologically acceptable salts thereof are disclosed.Type: GrantFiled: March 4, 1983Date of Patent: July 24, 1984Assignee: American Home Products CorporationInventors: John R. Potoski, Guy A. Schiehser, Donald P. Strike
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Patent number: 4458077Abstract: Compounds of the formulaAr--(CH.sub.2).sub.m --X--(CH.sub.2).sub.n --ONHRwherein R is ##STR1## wherein R.sup.1 is hydrogen or lower alkyl;X is O or CH.sub.2 ;m=0 or 1;n=2 or 3; andAr is a moiety selected from the group ##STR2## wherein R.sub.2 is hydrogen or lower alkyl, ##STR3## with the proviso that when Ar is ##STR4## and X is CH.sub.2, then R is other than ##STR5## and the pharmacologically acceptable salts thereof have H.sub.2 -antagonist activity and activity in decreasing gastric acid secretions.Type: GrantFiled: November 22, 1982Date of Patent: July 3, 1984Assignee: American Home Products CorporationInventor: John R. Potoski
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Patent number: 4394504Abstract: 7-[2-(3-Amino-5-isoxazolyl)-2-alkyloxy-iminoacetamido]-ceph-3-em-4-carboxyl ic acid derivatives are antibacterial agents effective against gram-positive and gram-negative bacterium.Type: GrantFiled: October 7, 1981Date of Patent: July 19, 1983Assignee: American Home Products CorporationInventors: Thomas J. Commons, John R. Potoski
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Patent number: 4225713Abstract: Compounds of the formula ##STR1## wherein: R is hydrogen, chlorine, or fluorine; andR.sup.1 is hydrogen, methyl, ethyl, propyl, or isopropyl;or a non-toxic acid addition salt thereof; exert an anti-hypertensive effect.Type: GrantFiled: November 3, 1978Date of Patent: September 30, 1980Inventors: Meier E. Freed, John R. Potoski
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Patent number: 4182869Abstract: Compounds of the formula ##STR1## wherein R is hydrogen (lower)alkyl, phen(lower)alkyl, benzoyl(lower)alkyl, or p-halobenzoyl(lower)alkyl; R.sup.1 is hydrogen or (lower)alkyl; R.sup.2 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, trifluoromethyl, or amino in the 7-, 8-, or 9-position; R.sup.3 is hydrogen, or (lower)alkyl; and R.sup.4 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, or trifluoromethyl in the 7-, 8-, or 9-position; or the non-toxic acid addition salts thereof; exert a hypotensive effect in hypertensive animals. Also disclosed are chemical intermediates including 4-carbobenzoxypiperazine-2-carboxylic acid.Type: GrantFiled: September 25, 1978Date of Patent: January 8, 1980Assignee: American Home Products CorporationInventors: Meier E. Freed, John R. Potoski
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Patent number: 4182872Abstract: Compounds of the formula ##STR1## wherein R is hydrogen (lower)alkyl, phen(lower)alkyl, benzoyl(lower)alkyl, or p-halobenzoyl(lower)alkyl; R.sup.1 is hydrogen or (lower)alkyl; R.sup.2 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, trifluoromethyl, or amino in the 7-, 8-, or 9-position; R.sup.3 is hydrogen, or (lower)alkyl; and R.sup.4 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, or trifluoromethyl in the 7-, 8-, or 9-position; or the non-toxic acid addition salts thereof; exert a hypotensive effect in hypertensive animals. Also disclosed are chemical intermediates, including 4-(lower)alkyl-1-(o-nitrophenyl)piperazine-2-carboxylic acids.Type: GrantFiled: September 25, 1978Date of Patent: January 8, 1980Assignee: American Home Products CorporationInventors: Meier E. Freed, John R. Potoski
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Patent number: 4138564Abstract: Compounds of the formula ##STR1## WHEREIN R is hydrogen, chlorine, or fluorine; andR.sup.1 is hydrogen, methyl, ethyl, propyl, or isopropyl;Or a non-toxic acid addition salt thereof; exert an anti-hypertensive effect.Type: GrantFiled: August 3, 1977Date of Patent: February 6, 1979Assignee: American Home Products CorporationInventors: Meier E. Freed, John R. Potoski
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Patent number: 4138567Abstract: Compounds of the formula ##STR1## wherein R is hydrogen (lower)alkyl, phen(lower)alkyl, benzoyl(lower)alkyl, or p-halobenzoyl(lower)alkyl; R.sup.1 is hydrogen or (lower)alkyl; R.sup.2 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, trifluoromethyl, or amino in the 7-, 8-, or 9-position; R.sup.3 is hydrogen, or (lower)alkyl; and R.sup.4 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, or trifluoromethyl in the 7-, 8-, or 9-position; or the non-toxic acid addition salts thereof; exert a hypotensive effect in hypertensive animals.Type: GrantFiled: September 22, 1977Date of Patent: February 6, 1979Assignee: American Home Products CorporationInventors: Meier E. Freed, John R. Potoski
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Patent number: 4089958Abstract: Compounds of the formula ##STR1## WHEREIN R is hydrogen (lower)alkyl, phen(lower)-alkyl, benzoyl(lower)alkyl, or p-halobenzoyl-(lower)alkyl; R.sup.1 is hydrogen or (lower)alkyl; R.sup.2 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, trifluoromethyl, or amino in the 7-, 8-, or 9-position; R.sup.3 is hydrogen, or (lower)alkyl; and R.sup.4 is hydrogen, (lower)-alkyl, (lower)alkoxy, chlorine, fluorine, or trifluoromethyl in the 7-, 8-, or 9-position; or the non-toxic acid addition salts thereof; exert a hyptotensive effect in hypertensive animals.Type: GrantFiled: December 20, 1976Date of Patent: May 16, 1978Assignee: American Home Products CorporationInventors: Meier E. Freed, John R. Potoski
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Patent number: 4076953Abstract: 1,3-Bridged-2-amino tetralins, having spiro substitution or the bridge, and intermediates thereto. The final products have analgesic activity.Type: GrantFiled: February 17, 1977Date of Patent: February 28, 1978Assignee: American Home Products CorporationInventors: Meier E. Freed, John R. Potoski
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Patent number: 4049701Abstract: Benzobicycloalkane amines, their pharmacologically acceptable addition salts, intermediates therefore the processes for their preparation and use. The compounds of the invention exert analgesic and anti-inflammatory activity.Type: GrantFiled: December 15, 1975Date of Patent: September 20, 1977Assignee: American Home Products CorporationInventors: Meier E. Freed, John R. Potoski