Patents by Inventor John R. Proudfoot

John R. Proudfoot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediate arylamine compounds
    Patent number: 7026476
    Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are and pharmaceutical compositions containing, intermediate compounds and processes of making such compounds.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: April 11, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Pier F. Cirillo, Steffen Breitfelder, Usha R. Patel, John R. Proudfoot, Alan D. Swinamer
  • Compounds useful as anti-inflammatory agents
    Patent number: 7019006
    Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: March 28, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Pier F. Cirillo, Steffen Breitfelder, Usha R. Patel, John R. Proudfoot, Alan D. Swinamer, Hidenori Takahashi, Thomas A. Gilmore, Rajiv Sharma
  • Methods of using soluble epoxide hydrolase inhibitors
    Patent number: 6890925
    Abstract: Disclosed are methods of using soluble epoxide hydrolase (sEH) inhibitors of the formulas I and Ia for diseases related to cardiovascular disease.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: May 10, 2005
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Richard H. Ingraham, John R. Proudfoot
  • Method of using soluble epoxide hydrolase inhibitors
    Patent number: 6831082
    Abstract: Disclosed are novel compounds of the formula Ia and methods of using soluble epoxide hydrolase (sEH) inhibitors of the formulas I and Ia for diseases related to cardiovascular disease.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: December 14, 2004
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Richard H. Ingraham, John R. Proudfoot
  • Methods of using soluble epoxide hydrolase inhibitors
    Publication number: 20040092567
    Abstract: Disclosed are methods of using soluble epoxide hydrolase (sEH) inhibitors of the formulas I and Ia for diseases related to cardiovascular disease.
    Type: Application
    Filed: September 25, 2003
    Publication date: May 13, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc
    Inventors: Richard H. Ingraham, John R. Proudfoot
  • Compounds useful as anti-inflammatory agents
    Patent number: 6660732
    Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: December 9, 2003
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rajashehar Betageri, Steffen Breitfelder, Pier F. Cirillo, Thomas A. Gilmore, Eugene R. Hickey, Thomas M. Kirrane, Monica H. Moriak, Neil Moss, Usha R. Patel, John R. Proudfoot, John R. Regan, Rajiv Sharma, Sanxing Sun, Alan D. Swinamer, Hidenori Takahashi
  • Intermediate arylamine compounds
    Publication number: 20030225077
    Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are and pharmaceutical compositions containing, intermediate compounds and processes of making such compounds.
    Type: Application
    Filed: April 28, 2003
    Publication date: December 4, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Pier F. Cirillo, Steffen Breitfelder, Usha R. Patel, John R. Proudfoot, Alan D. Swinamer
  • Method of using soluble epoxide hydrolase inhibitors
    Publication number: 20030022929
    Abstract: Disclosed are novel compounds of the formula Ia and methods of using soluble epoxide hydrolase (sEH) inhibitors of the formulas I and Ia for diseases related to cardiovascular disease.
    Type: Application
    Filed: June 14, 2002
    Publication date: January 30, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Richard H. Ingraham, John R. Proudfoot
  • Methods and labeled molecules for determining ligand binding to steroid receptors
    Publication number: 20030017503
    Abstract: The invention relates to fluorescence polarization (FP) methods for detecting and evaluating ligand binding to steroid receptors which are associated with heat shock proteins (hsps). The invention also relates to novel labeled molecules, in particular, fluorescence probes, which are useful in the methods of the invention.
    Type: Application
    Filed: May 20, 2002
    Publication date: January 23, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Susan E. Goldrick, Richard M. Nelson, James J. Crute, Ruby C. Wasti, Gerald H. Nabozny, John R. Proudfoot, David S. Thomson
  • Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
    Patent number: 6506747
    Abstract: 1-(4-aminophenyl)pyrazoles optionally substituted on the 3- and 5-positions of the pyrazole ring and on the amino group at the 4-position of the phenyl ring are disclosed and described, which pyrazoles inhibit IL-2 production in T-lymphocytes.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: January 14, 2003
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rajashekhar Betageri, Charles L. Cywin, Karl Hargrave, Mary Ann Hoermann, Thomas M. Kirrane, Thomas M. Parks, Usha R. Patel, John R. Proudfoot, Rajiv Sharma, Sanxing Sun, Xiao-Jun Wang
  • Compounds useful as anti-inflammatory agents
    Publication number: 20020082256
    Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.
    Type: Application
    Filed: September 25, 2001
    Publication date: June 27, 2002
    Inventors: Rajashehar Betageri, Steffen Breitfelder, Pier F. Cirillo, Thomas A. Gilmore, Eugene R. Hickey, Thomas M. Kirrane, Monica H. Moriak, Neil Moss, Usha R. Patel, John R. Proudfoot, John R. Regan, Rajiv Sharma, Sanxing Sun, Alan D. Swinamer, Hidenori Takahashi
  • Compounds useful as anti-inflammatory agents
    Publication number: 20020055507
    Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.
    Type: Application
    Filed: September 25, 2001
    Publication date: May 9, 2002
    Inventors: Rajashehar Betageri, Steffen Breitfelder, Pier F. Cirillo, Thomas A. Gilmore, Eugene R. Hickey, Thomas M. Kirrane, Monica H. Moriak, Neil Moss, Usha R. Patel, John R. Proudfoot, John R. Regan, Rajiv Sharma, Sanxing Sun, Alan D. Swinamer, Hidenori Takahashi
  • Compounds useful as anti-inflammatory agents
    Patent number: 6358945
    Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.
    Type: Grant
    Filed: February 16, 2000
    Date of Patent: March 19, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Steffen Breitfelder, Pier F. Cirillo, Thomas A. Gilmore, Eugene R. Hickey, John R. Proudfoot, John R. Regan, Alan D. Swinamer, Hidenori Takahashi
  • Src family SH2 domain inhibitors
    Patent number: 6284768
    Abstract: This invention relates to compounds of formula (I): wherein Ring a, A, B, C, D, E, R and Q are defined herein. These compounds possess the ability to disrupt the interaction between regulatory proteins possessing one or more SH2 domains and their native ligands.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: September 4, 2001
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rajashekhar Betageri, Pierre L. Beaulieu, Jean-Marie Ferland, Montse Llinas-Brunet, Neil Moss, Usha Patel, John R. Proudfoot, Mario Cardozo
  • Src family SH2 domain inhibitors
    Patent number: 6268365
    Abstract: This invention relates to compounds of formula (1): wherein Ring a, A, B, C, D, E, R and Q are defined herein. These compounds possess the ability to disrupt the interaction between regulatory proteins possessing one or more SH2 domains and their native ligands.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: July 31, 2001
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rajashekhar Betageri, Pierre L. Beaulieu, Jean-Marie Ferland, Montse Llinas-Brunet, Neil Moss, Usha Patel, John R. Proudfoot, Mario Cardozo
  • Compounds useful as phosphotyrosine mimics
    Patent number: 6156784
    Abstract: Disclosed are compositions containing compounds of the formula (I) below wherein A,B,C,G,Q and R are defined herein. The compounds are useful as phosphotyrosine mimics that, when incorporated into an appropriate molecular structure, inhibit the binding of tyrosine kinase-dependent regulatory proteins to their native phosphotyrosine-containing ligands or receptors. Also disclosed are methods for preparing the compounds of the formula (I).
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: December 5, 2000
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rajashekhar Betageri, Jean-Marie Ferland, Montse Llinas-Brunet, Neil Moss, John R. Proudfoot
  • Src family SH2 domain inhibitors
    Patent number: 6054470
    Abstract: This invention relates to compounds of formula (1): ##STR1## wherein Ring a, A, B, C, D, E, R and Q are defined herein. These compounds possess the ability to disrupt the interaction between regulatory proteins possessing one or more SH2 domains and their native ligands.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: April 25, 2000
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rajashekhar Betageri, Pierre L. Beaulieu, Jean-Marie Ferland, Montse Llinas-Brunet, Neil Moss, Usha Patel, John R. Proudfoot, Mario Cardozo
  • 5,6-Heteroaryl-dipyrido(2,3-B:3', 2'-F) azepines and their use in the prevention or treatment of HIV infection
    Patent number: 5919779
    Abstract: "There are disclosed compounds of the formula I, II or III ##STR1## wherein A and D are carbon or nitrogen and B is oxygen, sulfur or nitrogen which are useful in the prevention or treatment of HIV infection.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: July 6, 1999
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: John R. Proudfoot, Karl D. Hargrave, Suresh Kapadia
  • 5,11-dihydro-6H-dipyrido?3,2-b:2',3'-e!azepine-6-ones and their use in the prevention of treatment of HIV infection
    Patent number: 5908841
    Abstract: There are disclosed compounds of the formula 1 ##STR1## wherein X is an oxygen atom or nothing and R1, R2 and R3 are as defined in the specification, useful in the prevention or treatment of HIV infection.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: June 1, 1999
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: John R. Proudfoot, Karl D. Hargrave
  • Dipyridio?2,3-b:3',2'-! azepines and their use in the prevention or treatment of HIV infection
    Patent number: 5869482
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: February 9, 1999
    Assignee: Boehringer Ingelheim Pharmacueticals, Inc.
    Inventors: John R. Proudfoot, Alexey B. Dyatkin