Patents by Inventor John R. Silber

John R. Silber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IRON OXIDE NANOPARTICLE FOR SUPPRESSING DRUG-RESISTANT GENE FOR THE TREATMENT OF GLIOBLASTOMA
    Publication number: 20230405145
    Abstract: A nanoparticle for targeted siRNA delivery comprising an iron oxide core and a chitosan-polyethylene glycol-polyethylenimine copolymer coating surrounding the core, chlorotoxin covalently coupled to the coating, and an siRNA reversibly associated to the coating by non-covalent interaction. Methods for making the nanoparticle and methods for using the nanoparticle to suppress the expression of O6-methylguanine-DNA methyltransferase (MGMT), treating brain cancer, and killing cancer stem cells.
    Type: Application
    Filed: October 6, 2021
    Publication date: December 21, 2023
    Applicant: University of Washington
    Inventors: Miqin Zhang, Richard G. Ellenbogen, Kui Wang, Forrest M. Kievit, John R. Silber, Zachary Stephen, Peter A. Chiarelli
  • Nanoparticle for targeting brain tumors and delivery of O-benzylguanine
    Patent number: 9784730
    Abstract: Nanoparticle having a crosslinked chitosan-polyethylene oxide oligomer copolymer coating to which O6-benzylguanine is covalently coupled, compositions that include the nanoparticle, and methods for using the nanoparticle to treat brain cancers.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: October 10, 2017
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Richard G. Ellenbogen, Forrest Kievit, John R. Silber, Zachary Stephen, Omid Veiseh
  • NANOPARTICLE FOR TARGETING BRAIN TUMORS AND DELIVERY OF O6-BENZYLGUANINE
    Publication number: 20140286872
    Abstract: Nanoparticle having a crosslinked chitosan-polyethylene oxide oligomer copolymer coating to which O6-benzylguanine is covalently coupled, compositions that include the nanoparticle, and methods for using the nanoparticle to treat brain cancers.
    Type: Application
    Filed: March 21, 2014
    Publication date: September 25, 2014
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Richard G. Ellenbogen, Forrest Kievit, John R. Silber, Zachary Stephen, Omid Veiseh