Patents by Inventor John R. Speakman

John R. Speakman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Triple isotope method and analyzer for total energy expenditure measurements
    Patent number: 8823923
    Abstract: A method of measuring energy expenditure in a living subject comprises: (a) administering a specified dose of doubly-labeled water (2H218O) to a living subject; (b) obtaining samples at three or more times of body water from the living subject; (c) measuring 2H/1H, 17O/16O and 18O/16O ratios in each of the obtained samples using optical spectroscopy; and (d) determining (1) a combined value of flux of body water and exhaled carbon dioxide from a change in measured 18O/16O over time, (2) a value of flux of body water alone from a change in measured 2H/1H over time, and (3) a reference value of isotopic background fluctuation from a change in measured 17O/16O over time. Using 17O measurements to estimate background fluctuations of the 2H and 18O decreases the required isotope dosing of subjects or decreases uncertainty at current dosing levels.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: September 2, 2014
    Assignee: ABB Research Ltd.
    Inventors: Elena S. F. Berman, John R. Speakman, Manish Gupta, Edward L. Melanson, Jr., Susan L. Fortson, Douglas S. Baer
  • TRIPLE ISOTOPE METHOD AND ANALYZER FOR TOTAL ENERGY EXPENDITURE MEASUREMENTS
    Publication number: 20130027705
    Abstract: A method of measuring energy expenditure in a living subject comprises: (a) administering a specified dose of doubly-labeled water (2H218O) to a living subject; (b) obtaining samples at three or more times of body water from the living subject; (c) measuring 2H/1H, 17O/16O and 18O/16O ratios in each of the obtained samples using optical spectroscopy; and (d) determining (1) a combined value of flux of body water and exhaled carbon dioxide from a change in measured 18O/16O over time, (2) a value of flux of body water alone from a change in measured 2H/1H over time, and (3) a reference value of isotopic background fluctuation from a change in measured 17O/16O over time. Using 17O measurements to estimate background fluctuations of the 2H and 18O decreases the required isotope dosing of subjects or decreases uncertainty at current dosing levels.
    Type: Application
    Filed: March 21, 2012
    Publication date: January 31, 2013
    Applicant: LOS GATOS RESEARCH
    Inventors: Elena S.F. Berman, John R. Speakman, Manish Gupta, Edward L. Melanson, JR., Susan L. Fortson, Douglas S. Baer