Patents by Inventor John R. TEIJARO

John R. TEIJARO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS FOR USE IN ANTI-CANCER IMMUNOTHERAPY
    Publication number: 20220226281
    Abstract: The present disclosure relates to the reversal of T cell exhaustion using aplysiatoxin analogs or PKC theta agonist compounds for anti-cancer immunotherapy. The treatment with aplysiatoxin analogs or PKC theta agonist compounds improve the anti-tumour activity of a T cell, inducing a NFAT-dependent T cell activation, increasing the pool of immune-checkpoint inhibitor responsive T cells, increasing lymphocyte infiltration and increasing the population of activated CD4+ and/or CD8+ cells. The methods of the present disclosure provide treatment of tumors and infections.
    Type: Application
    Filed: May 28, 2020
    Publication date: July 21, 2022
    Inventors: Steven Bruce Cohen, Dan Lu, Farhana Barmare, Ippei Usui, Venkata Rami Reddy Macherla, Elizabeth Paige Stout, Jacob Neal Beverage, Eduardo Esquenazi, Peter A. Jordan, Phil S. Baran, John R. Teijaro
  • CYSTEINE REACTIVE PROBES AND USES THEREOF
    Publication number: 20200292555
    Abstract: Disclosed herein are methods, compositions, probes, polypeptides, assays, and kits for identifying a cysteine containing protein as a binding target for a small molecule fragment. Also disclosed herein are methods, compositions, and probes for mapping a biologically active cysteine site on a protein and screening a small molecule fragment for interaction with a cysteine containing protein.
    Type: Application
    Filed: June 2, 2020
    Publication date: September 17, 2020
    Inventors: Benjamin F. CRAVATT, Keriann M. BACKUS, Bruno E. CORREIA, Megan M. BLEWETT, John R. TEIJARO
  • Cysteine reactive probes and uses thereof
    Patent number: 10670605
    Abstract: Disclosed herein are methods, compositions, probes, polypeptides, assays, and kits for identifying a cysteine containing protein as a binding target for a small molecule fragment. Also disclosed herein are methods, compositions, and probes for mapping a biologically active cysteine site on a protein and screening a small molecule fragment for interaction with a cysteine containing protein.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: June 2, 2020
    Assignee: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Benjamin F. Cravatt, Keriann M. Backus, Bruno E. Correia, Megan M. Blewett, John R. Teijaro
  • CYSTEINE REACTIVE PROBES AND USES THEREOF
    Publication number: 20170115303
    Abstract: Disclosed herein are methods, compositions, probes, polypeptides, assays, and kits for identifying a cysteine containing protein as a binding target for a small molecule fragment. Also disclosed herein are methods, compositions, and probes for mapping a biologically active cysteine site on a protein and screening a small molecule fragment for interaction with a cysteine containing protein.
    Type: Application
    Filed: October 21, 2016
    Publication date: April 27, 2017
    Inventors: Benjamin F. CRAVATT, Keriann M. BACKUS, Bruno E. CORREIA, Megan M. BLEWETT, John R. TEIJARO