Patents by Inventor John R. Wetterau, II

John R. Wetterau, II has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microsomal triglyceride transfer protein
    Patent number: 6492365
    Abstract: Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 10, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: John R. Wetterau, II, Daru Young Sharp, Richard E. Gregg
  • Method of treating acid lipase deficiency diseases with an MTP inhibitor and cholesterol lowering drugs
    Patent number: 6066653
    Abstract: A method is provided for inhibiting or treating diseases associated with acid lipase deficiency by administering to a patient an MTP inhibitor, alone or optionally, in combination with another cholesterol lowering drug, such as pravastatin.
    Type: Grant
    Filed: January 10, 1998
    Date of Patent: May 23, 2000
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Richard E. Gregg, John R. Wetterau, II
  • Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
    Patent number: 5883109
    Abstract: A method is provided for lowering serum lipids, cholesterol and/or triglycerides and thereby inhibiting atherosclerosis by administering to a patient an MTP inhibitor, in combination with a cholesterol lowering drug, such as pravastatin.
    Type: Grant
    Filed: May 12, 1997
    Date of Patent: March 16, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Richard E. Gregg, Hubert G. Pouleur, John R. Wetterau, II
  • Microsomal triglyceride transfer protein
    Patent number: 5789197
    Abstract: Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 4, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John R. Wetterau, II, Daru Young Sharp, Richard E. Gregg
  • Nucleic acids encoding microsomal trigyceride transfer protein
    Patent number: 5595872
    Abstract: Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.
    Type: Grant
    Filed: September 3, 1993
    Date of Patent: January 21, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: John R. Wetterau, II, Daru Y. Sharp, Richard E. Gregg, Scott A. Biller, John K. Dickson, R. Michael Lawrence, John E. Lawson, Henry M. Holava, Richard A. Partyka