Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

Abstract: The present disclosure provides a system for anticipating environmental conditions within a critical environment needed to maintain a set of established environmental parameters within the critical environment. The system includes process equipment for maintaining the set of established environmental parameters within the critical environment and sensors to obtain sensor data from the environment. The system also includes controllers controlling the operation of the process equipment and an onsite server in communication with the sensor to receive the sensor data from the sensors and in communication with the controllers to transmit control data to the controllers, the onsite server further including a prediction engine.

Abstract: Systems and methods are described herein for resurfacing bones, and in particular, for detecting and resurfacing one or more femoroacetabular impingements (FAIs). A FAI resurfacing controller may be used to perform this detecting and resurfacing of FAIs. The FAI resurfacing controller may include a bone model generator to receive bone imaging and to generate a model of at least one osteophyte and of a surface of a native bone surrounding the at least one osteophyte. The FAI resurfacing controller may include an osteophyte identifier to set a virtual 3D boundary surface between native bone surface and the at least one osteophyte. The FAI resurfacing controller may include a resurfacing navigator to generate and output a navigation file. The navigation file may include the model with the 3D boundary surface between native bone surface and the at least one osteophyte.

Abstract: Systems and methods are described herein for resurfacing bones, and in particular, for detecting and resurfacing one or more femoroacetabular impingements (FAIs). A FAI resurfacing controller may be used to perform this detecting and resurfacing of FAIs. The FAI resurfacing controller may include a bone model generator to receive bone imaging and to generate a model of at least one osteophyte and of a surface of a native bone surrounding the at least one osteophyte. The FAI resurfacing controller may include an osteophyte identifier to set a virtual 3D boundary surface between native bone surface and the at least one osteophyte. The FAI resurfacing controller may include a resurfacing navigator to generate and output a navigation file. The navigation file may include the model with the 3D boundary surface between native bone surface and the at least one osteophyte.

Abstract: A method for sequencing veneer to lumbercore includes receiving a veneer grain width input and a veneer thickness input, determining a cut angle based on the veneer grain width input and the veneer thickness input, receiving a lumbercore width input and a lumbercore height input, determining a set of dimensions for a stack of lumber, and generating a template mapping the lumbercore to the stack of lumber, where the template is based on the lumbercore width input, the lumbercore height input, and the set of dimensions for the stack of lumber, where the lumbercore is rotated within the template at an angle relative to horizontal within the stack of lumber by an amount equal to the cut angle.

Abstract: A tread extraction assembly is provided. The tread extraction assembly includes a base frame, a first clamping assembly, and a second clamping assembly. The base frame defines a leading edge. The first clamping assembly includes a first clamp movable relative to the base frame. The second clamping assembly is coupled to the base frame and includes a second clamp positioned proximate to the leading edge. The tread extraction assembly also includes a linear rail and a linear bearing. The first clamping assembly is coupled to the linear bearing and movable along the linear rail by a linear actuator.

Abstract: A method for sequencing veneer to lumbercore includes receiving a veneer grain width input and a veneer thickness input, determining a cut angle based on the veneer grain width input and the veneer thickness input, receiving a lumbercore width input and a lumbercore height input, determining a set of dimensions for a stack of lumber, and generating a template mapping the lumbercore to the stack of lumber, where the template is based on the lumbercore width input, the lumbercore height input, and the set of dimensions for the stack of lumber, where the lumbercore is rotated within the template at an angle relative to horizontal within the stack of lumber by an amount equal to the cut angle.

Abstract: Systems and methods are described herein for resurfacing bones, and in particular, for detecting and resurfacing one or more femoroacetabular impingements (FAIs). A FAI resurfacing controller may be used to perform this detecting and resurfacing of FAIs. The FAI resurfacing controller may include a bone model generator to receive bone imaging and to generate a model of at least one osteophyte and of a surface of a native bone surrounding the at least one osteophyte. The FAI resurfacing controller may include an osteophyte identifier to set a virtual 3D boundary surface between native bone surface and the at least one osteophyte. The FAI resurfacing controller may include a resurfacing navigator to generate and output a navigation file. The navigation file may include the model with the 3D boundary surface between native bone surface and the at least one osteophyte.

Abstract: Systems and methods for using an augmented reality device during patient diagnosis. A method may include capturing an image of a patient, and presenting using an augmented reality display, while permitting the patient to be viewed through the augmented reality display, a virtual feature corresponding to anatomy of the patient obtained from the image. The method may include detecting impingement of the anatomy of the patient based on the image and displaying on the augmented reality display, an indication of the impingement at the virtual feature, such as by changing an attribute of the virtual feature.

Abstract: The present invention relates to systems, methods and apparatus for multi-dimensional conveyor which allows for the planting, growing and harvesting of plants and plant material in a manner which optimizes yield, allows for consistency, allows production and harvesting to be automated, and allows production to proceed in conditions which may be most favorable to biologic activities associated with plant products. The entire apparatus can be constructed of lightweight, cost-effective materials, which afford mass-production and mass-array into vast automatic growing operations.

Abstract: A loader device includes a support pedestal movable over a range of longitudinal travel along a longitudinal axis, a support carriage movably mounted to the support pedestal, a loader actuator, and a dismount actuator. The support carriage is movable over a range of vertical travel along a normal axis, which is perpendicular to the longitudinal axis. The support carriage has a support arm adapted to support a tire casing. The loader actuator and dismount actuator are respectively adapted to selectively move: (1) at least a portion of a tire casing supported upon the support carriage in a loading direction along the longitudinal axis off of the support arm onto the expandable rim hub and (2) at least a portion of a tire casing supported upon the expandable rim hub in an opposing unloading direction off of the expandable rim hub and onto the support arm of the loader device.

Abstract: Systems and methods for using an augmented reality device during patient diagnosis. A method may include capturing an image of a patient, and presenting using an augmented reality display, while permitting the patient to be viewed through the augmented reality display, a virtual feature corresponding to anatomy of the patient obtained from the image. The method may include detecting impingement of the anatomy of the patient based on the image and displaying on the augmented reality display, an indication of the impingement at the virtual feature, such as by changing an attribute of the virtual feature.

Abstract: An orthopedic implant includes a first portion including at least one feature modified to be patient-specific and match the anatomy of a specific patient from a three-dimensional digital image of a patient's joint using computer modeling. The orthopedic implant includes a non-custom inner bone-engaging surface including a plurality of planar surfaces configured for engagement with non-custom bone cuts.

Abstract: An acetabular device includes a patient-specific acetabular alignment guide including a bone engagement surface. The bone engagement surface has a first portion configured and shaped to be conforming and complementary to an acetabular rim surface and a second portion configured and shaped to be conforming and complementary to a periacetabular area of an acetabulum of a patient. The acetabular alignment guide includes a plurality of guiding formations extending through the second portion for guiding a plurality of alignment pins therethrough. The bone engagement surface and the plurality of guiding formations are prepared from a three-dimensional model of the acetabulum of the specific patient reconstructed pre-operatively from a scan of the patient.

Abstract: An orthopedic implant includes a first portion including at least one feature modified to be patient-specific and match the anatomy of a specific patient from a three-dimensional digital image of a patient's joint using computer modeling. The orthopedic implant includes a non-custom inner bone-engaging surface including a plurality of planar surfaces configured for engagement with non-custom bone cuts.

Abstract: A system and method for using augmented reality device for use during a surgical procedure are described. A system may include an augmented reality device to present a virtual indication, such as a virtual indication of a surgical instrument, a force vector, a direction, or the like. The augmented reality device may present a virtual aspect of a procedure, such as a virtual animation of a step of a procedure. The augmented reality device may present a virtual object, indication, aspect, etc., within a surgical field while permitting the surgical field or aspects of the surgical field to be viewed through the augmented reality display (e.g., presenting virtual objects mixed with real objects).

Abstract: Various systems, devices, and methods for facilitating efficient anatomical registration in surgical navigation are disclosed. Such systems, devices, and methods can provide for relatively rapid collection of individual physical space data corresponding to a plurality of surface points during a dynamic data collection mode of a detection unit. Additionally or alternatively, such systems, devices, and methods can provide for collection of a plurality of data at a single point collection mode of a detection unit. The system can have a data collection unit and a registration probe. A distal portion of the registration probe can have an engagement tip. The engagement tip can be a dynamic engagement tip or a functional engagement tip.

Abstract: An acetabular device includes a patient-specific acetabular alignment guide including a bone engagement surface. The bone engagement surface has a first portion configured and shaped to be conforming and complementary to an acetabular rim surface and a second portion configured and shaped to be conforming and complementary to a periacetabular area of an acetabulum of a patient. The acetabular alignment guide includes a plurality of guiding formations extending through the second portion for guiding a plurality of alignment pins therethrough. The bone engagement surface and the plurality of guiding formations are prepared from a three-dimensional model of the acetabulum of the specific patient reconstructed pre-operatively from a scan of the patient.

Abstract: A surgical device includes a guiding instrument; a protector comprised of a protective material held in a non-protecting state by the guiding instrument and having a protection state; and an actuator connected to the protector that is configured to advance the protector along the guiding instrument such that the protector is allowed to assume the protection state.

Abstract: Disclosed is an orthopedic implant that includes an anchor, a bore, and a compressible and expandable mesh. The anchor is configured to secure the implant at an implantation site and defines a longitudinal axis. The bore is defined by the anchor and extends along the longitudinal axis. The compressible and expandable mesh is aligned along the longitudinal axis and defines a plurality of openings. The mesh is configured to compress along the longitudinal axis and expand from the longitudinal axis to engage surrounding bone or tissue at the implantation site to secure the implant at the implantation site.