Patents by Inventor John R. Yates, III

John R. Yates, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Automatic detection of quality spectra
    Patent number: 7230235
    Abstract: The present application provides systems and/or methods for accessing a portion of a mass-fragment spectrum, constructing a vector that is responsive to an intensity-balance of the spectrum, and selecting the spectrum responsive to the vector.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: June 12, 2007
    Assignees: Palo Alto Research Center Incorporated, The Scripps Research Institute
    Inventors: David Goldberg, Marshall W. Bern, John R. Yates, III
  • Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
    Patent number: 6017693
    Abstract: A method for correlating a peptide fragment mass spectrum with amino acid sequences derived from a database is provided. A peptide is analyzed by a tandem mass spectrometer to yield a peptide fragment mass spectrum. A protein sequence database or a nucleotide sequence database is used to predict one or more fragment spectra for comparison with the experimentally-derived fragment spectrum. In one embodiment, sub-sequences of the sequences found on the database which define a peptide having a mass substantially equal to the mass of the peptide analyzed by the tandem mass spectrometer are identified as candidate sequences. For each candidate sequence, a plurality of fragments of the sequence are identified and the masses and m/z ratios of the fragments are predicted and used to form a predicted mass spectrum.
    Type: Grant
    Filed: November 27, 1996
    Date of Patent: January 25, 2000
    Assignee: University of Washington
    Inventors: John R. Yates, III, Jimmy K. Eng
  • Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
    Patent number: 5538897
    Abstract: A method for correlating a peptide fragment mass spectrum with amino acid sequences derived from a database is provided. A peptide is analyzed by a tandem mass spectrometer to yield a peptide fragment mass spectrum. A protein sequence database or a nucleotide sequence database is used to predict one or more fragment spectra for comparison with the experimentally-derived fragment spectrum. In one embodiment, sub-sequences of the sequences found on the database which define a peptide having a mass substantially equal to the mass of the peptide analyzed by the tandem mass spectrometer are identified as candidate sequences. For each candidate sequence, a plurality of fragments of the sequence are identified and the masses and m/z ratios of the fragments are predicted and used to form a predicted mass spectrum.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: July 23, 1996
    Assignee: University of Washington
    Inventors: John R. Yates, III, James K. Eng