Abstract: The invention provides novel ?2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ?2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

Abstract: The present invention describes terminal phosphate blocked nucleoside polyphosphates that are stable at high temperature and their use in nucleic acid amplification and analysis. Current invention further describes charge modified terminal phosphate blocked nucleoside polyphosphates for improved incorporation and direct loading of nucleic acid sequencing reactions onto separating media.

Abstract: The clocks of remote computing devices are synchronized within a range of certainty through the determination of an upper bound and a lower bound around a reference time. A message from a computing device is propagated up a network tree of devices to a device having a reference time, which encodes the reference time and returns the message down the tree. Each receiving device can determine that the reference time could not have occurred before their transmission of the message, nor could it have occurred after their receipt of the return message. Cryptographic hashes can be used to guard against malicious computing devices. Alternate paths and scheduling of messages can be used to provide a narrower spread between the upper and lower bounds, and clock drift can be accounted for by increasing the spread over time.

Abstract: The invention provides a circuit that can observe data within shift registers without altering the data. The circuit includes selectors connected to the inputs and outputs of the shift registers. The selectors selectively connect the input with the output of a selected shift register to form a wiring loop for the selected shift register. A control device connected to the wiring loop uses the wiring loop to cause the data to be continually transferred from the output of the selected shift register to the input of the selected shift register and back through the selected shift register in a circular manner. The control device includes a counter used for determining the length of a selected shift register and a set of registers to store, for future use when rotating data in the shift registers, the length of each shift register. The control device also includes a data output accessible from outside the circuit.

Abstract: Hydrogen generators and integrated hydrogen generator/fuel cells systems are operated by determining the condition of the hydrogen generator and the condition of the fuel to the hydrogen generator for selection of predetermined flow rates for each of the externally-provided raw materials. The processes of the invention can provide rapid transitions between hydrogen production rates while enabling enhanced efficiency and stability during transient operations.

Abstract: A surgical access device has a surgical retractor having a noncompliant outer ring with an annular axis, an inner ring, and a sleeve coupling the outer ring to the inner ring. The noncompliant outer ring is adapted to roll over itself around the annular axis to roll the sleeve around the outer ring to retract and seal an opening in a biological body wall. The access device may include a lid adapted for being coupled to the noncompliant outer ring of the surgical retractor. The outer ring of the surgical retractor has a cross-sectional shape that prohibits the lid from being partially or incorrectly coupled to the outer ring of the surgical retractor.

Abstract: A powered unit for performing blower operations or vacuuming operations is provided. The powered unit includes a blower tube, a barrier for preventing unintentional contact with moving parts in the powered unit, and a retention feature. The retention feature is located within the blower tube and the retention feature is configured for securing the barrier within the blower tube. The retention feature is included of an annular groove in the blower tube. The barrier is secured in the blower tube by a snap engagement with the retention feature. The barrier can also be deformed as it is inserted into the blower tube. The barrier then returns to its non-deformed shape when the barrier is secured in the retention feature in the blower tube.

Abstract: A surgical access device has a surgical retractor having a noncompliant outer ring with an annular axis, an inner ring, and a sleeve coupling the outer ring to the inner ring. The noncompliant outer ring is adapted to roll over itself around the annular axis to roll the sleeve around the outer ring to retract and seal an opening in a biological body wall. The access device may include a lid adapted for being coupled to the noncompliant outer ring of the surgical retractor. The outer ring of the surgical retractor has a cross-sectional shape that prohibits the lid from being partially or incorrectly coupled to the outer ring of the surgical retractor.

Abstract: A creep steering control system for a utility vehicle is operable from a rearward-facing position. The creep steering control system includes a pivotable actuator alongside a rearward-facing seat that provides electronic output based on the position of the actuator. A linkage is provided between the pivotable actuator and steering wheel behind the seat.

Abstract: Interoperability is enabled between participants in a network by determining values associated with a value metric defined for at least a portion of the network. Information flow is directed between two or more of the participants based at least in part on semantic models corresponding to the participants and on the values associated with the value metric. The semantic models may define interactions between the participants and define at least a portion of information produced or consumed by the participants. The determination of the values and the direction of the information flow may be performed multiple times in order to modify the one or more value metrics. The direction of information flow may allow participants to be deleted from the network, may allow participants to be added to the network, or may allow behavior of the participants to be modified.

Abstract: The present invention relates to, inter alia, methods for the treatment of wallboards and the treated wallboards. In particular, the invention relates to the treatment of wallboards with a fungicidally effective amount of a strobilurin or strobilurin-type fungicide. In a particular embodiment the fungicide is azoxystrobin. The invention also provides for the treatment of wallboards and building materials with combinations of fungicides present in synergistic amounts.

Abstract: Methods and apparatuses for improved damping in high-temperature superconducting levitation systems are disclosed. A superconducting element (e.g., a stator) generating a magnetic field and a magnet (e.g. a rotor) supported by the magnetic field are provided such that the superconducting element is supported relative to a ground state with damped motion substantially perpendicular to the support of the magnetic field on the magnet. Applying this, a cryostat housing the superconducting bearing may be coupled to the ground state with high damping but low radial stiffness, such that its resonant frequency is less than that of the superconducting bearing. The damping of the cryostat may be substantially transferred to the levitated magnetic rotor, thus, providing damping without affecting the rotational loss, as can be derived applying coupled harmonic oscillator theory in rotor dynamics. Thus, damping can be provided to a levitated object, without substantially affecting the rotational loss.

Abstract: This invention is directed to carboxamido opioid compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a central nervous system disorder.

Abstract: A system for power amplification of an RF signal including polar feedback control. The system may include a feedback-controlled modulator configured to modulate an RF signal based on a feedback-corrected control signal. The modulator is further configured to generate a modulated RF signal. The system also may include a phase shifter configured to correct the phase of the modulated RF signal based on a feedback phase control signal. The system further includes a power amplifier in communication with the modulator and/or the phase shifter. The amplifier is configured to amplify the modulated RF signal and to generate an amplified RF output signal. The system also includes a feedback network configured to generate polar feedback signals, including the feedback-corrected control signal and/or the feedback phase control signal.

Abstract: Method and system of placing a RFID tag in a continuous transmission mode. At least some of the illustrative embodiments are methods comprising sending a command from a radio frequency identification (RFID) reader to a first RFID tag, and then transmitting continuously by the first RFID tag based on the command. Other illustrative embodiments are RFID tags comprising a tag antenna, and a RFID circuit coupled to the tag antenna. The RFID circuit is configured to, responsive to a first command from a RFID reader, repeatedly transmit a message to the RFID reader.

Abstract: A method of automatically identifying a region of differing intensity in a functional image is described.

Abstract: A turbofan gas turbine engine (10) comprises a compressor rotor (24) carrying a plurality of circumferentially spaced radially extending rotor blades (26) and a casing (28) surrounding the compressor rotor (24) and compressor rotor blades (26). A compressor rotor blade tip seal (48) comprises an annular member (30) secured to and arranged within the casing (28). The annular member (40) has a plurality of circumferentially spaced axially extending corrugations (32) and a plurality of radially spaced circumferentially extending corrugations (34). A lining (40) is secured to and arranged within the annular member (30). The lining (40) is spaced radially from the tips (27) of the compressor rotor blades (26) to form a clearance (29). An actuator (56) is provided to move the annular member (30) and lining (40) radially to control the size of the clearance (29).

Abstract: A fluid injection system is used in a well. Fluid stages are arranged in repeating series within a tubing of the fluid injection system to facilitate control over effects of injection. A sensor system can be used to detect one or more parameters related to the fluids moved downhole through the tubing to further enhance injection procedures.

Abstract: A sensor measures the current in high frequency pulses (e.g., pulses having fast rise times) that are transported on coaxial transmission lines. The sensor includes an entrance coaxial conductor and an exit coaxial conductor that are interconnected by a continuous inner conductor. The outer conductors of the two coaxial conductors are interrupted and are interconnected by a sensing resistor with a substantially constant resistance. An output sensor coaxial conductor has an inner conductor electrically connected to a first end of the sensing resistor and has an outer conductor connected to a second end of the sensing resistor. Tapered ferrite cores are placed around the three coaxial conductors proximate the connections to the sensing resistor. Preferably, the sensing resistor is a tubular resistor formed on a dielectric cylindrical tube. The sensor is enclosed within a continuous conductive housing.

Abstract: A volumetric representation of a hair simulation model determines collective hair attributes. To determine inter-hair collisions, vertices include average velocities of the adjacent portions of the model. The average velocities determine target velocities. Forces for the model are determined from the target velocity values. To direct hair to a desired pose, vertices include target and current density values representing the density of adjacent portions of the model in the desired pose and current position, respectively. The differences in density values determine pressure forces applied to the model. To determine the illumination of the hair, vertices include density values representing the density of adjacent portions of the model. The density values define a hair surface, and signed distance values relative to the surface are determined for the vertices. Normal vectors are determined from the gradients of the signed distance values at locations corresponding the positions of the hairs.