Abstract: A method for mitigating an involuntary muscle movement in a patient by applying external vibration in multiple locations distributed about a periphery of an upper arm or forearm of the patient for an applied vibration duration that is less than the efficacy duration. Applied vibration duration as a percentage of efficacy duration is ideally less than 80%. A wearable device for performing the method has a flexible base for removably affixing to a patient's upper arm or forearm, a plurality of vibration generators, a power source, and a connected microcontroller configured to control the vibration generated by the vibration generators in accordance with a pulse frequency. The microcontroller is configured to connect to a remote controller via a communications interface. The vibration generators have a nominal vibration frequency different from the pulse frequency.

Abstract: The present invention relates to carrying out infrared emission spectroscopic measurements using a sample directly or a substrate, on which a sample is placed, coated, spun-on, deposited or in some way attached, as an external source to produce a time dependent infrared emissive signature from said sample or substrate with a subsequent analysis of this signature by an infrared spectrograph equipped with a focal plane array detector.

Abstract: A functionalized electrospun matrix for the controlled-release of biologically active agents, such as growth factors, is presented. The functionalized matrix comprises a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin.

Abstract: Nanofiber electroprocessing apparatus comprising a conductive stylus having a 5 to 250 nm diameter tip; a collector spaced below the tip; a continuous supply of flowable polymer to the tip, and a power supply for creating a potential difference between the tip and the collector sufficient to produce a nanofiber. The conductive stylus may comprise an atomic force microscope (AFM) tip and may further be mounted within an AFM scanning holder having a mechanism for moving the tip. A method of electroprocessing a nanofiber comprises providing the conductive stylus, such as an AFM tip, providing a collector below the tip, supplying the tip with the flowable polymer, energizing the tip to create a potential difference between the tip and the collector, and thereby producing the nanofiber. Systems and methods for using nanofibers so created may be used for anticounterfeiting or object identification.

Abstract: A functionalized electrospun matrix for the controlled-release of biologically active agents, such as growth factors, is presented. The functionalized matrix comprises a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin.

Abstract: The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin. Examples of active molecules that may be used with the multicomponent polymer of the invention include, for example, a drug, a biopolymer, for example a growth factor, a protein, a peptide, a nucleotide, a polysaccharide, a biological macromolecule or the like. The invention is further directed to the formation of functionalized crosslinked matrices, such as hydrogels, that include at least one functionalized compatibilizing polymer capable of assembly.

Abstract: A process to make a dyed fiber which has the steps of mixing a dye capable of changing color and a polymer into a solution at a temperature below the temperature at which the dye or polymer degrades to form a polymer dye solution and electrospinning said polymer dye solution to form a fiber wherein the dye penetrates more than the surface of the fiber. The invention also relates to the fiber and use of the fiber.

Abstract: The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin. Examples of active molecules that may be used with the multicomponent polymer of the invention include, for example, a drug, a biopolymer, for example a growth factor, a protein, a peptide, a nucleotide, a polysaccharide, a biological macromolecule or the like. The invention is further directed to the formation of functionalized crosslinked matrices, such as hydrogels, that include at least one functionalized compatibilizing polymer capable of assembly.

Abstract: A method for producing a webbed fibrillar material includes providing a polymer material including a solvent; injecting the polymer material into an electric field toward an electrically charged target; controlling at least one process parameter to produce the webbed fibrillar material having one or more desired characteristics; and collecting the webbed fibrillar material from the target. The process parameter may be selected from the group consisting of an electric field strength, a temperature, a solution viscosity of the polymer material, a distance between an injection point and the target, a solvent type, a relative concentration of the solvent and polymer material, a molecular weight of the molecules of the polymer material, an environmental temperature, an environmental humidity, and a drying time of the injected polymer material.