Abstract: The present disclosure relates to methods of treating organic acidemias. In some embodiments, the methods comprise reducing propionyl-CoA, isovaleryl-CoA and methylmalonyl-CoA production, and various related metabolites, in a subject in need thereof.

Abstract: The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.

Abstract: Disclosed embodiments provide a framework to allow users of a peer-to-peer music recommendation service to generate and transmit music recommendation requests to other users of the service and obtain music recommendations that are relevant to these requests. In response to receiving a request to obtain music recommendations, the service transmits the request to a set of recipients specified in the request and from which music recommendations are to be solicited. The request specifies information that is indicative of the types of music being solicited. A recommendation received from a recipient includes identifying information of a song accessible via another music service and information indicative of a type of music of the song. Any received recommendations are presented in response to the request and feedback with regard to these recommendations is collected. Based on the provided feedback, profiles of the recipients that submitted the recommendations are updated.

Abstract: The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.

Abstract: An implantable pulse generator includes a device housing containing pulse generator circuitry and a header connected to the device housing. The header includes a core assembly defining first and second lead bore cavities sized for receiving terminal pins of leads, first and second labels, and an outer layer. The first label is printed onto a surface of the core assembly proximate the first lead bore cavity and includes a first color. The second label is printed onto the surface of the core assembly proximate the second lead bore cavity and includes a second color different from the first color. The outer layer is overmolded over the core assembly so as to encapsulate the first and second labels and to allow access to the first and second lead bore cavities.

Abstract: The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.

Abstract: The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.

Abstract: The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.

Abstract: An implantable pulse generator includes a device housing containing pulse generator circuitry and a header connected to the device housing. The header includes a core assembly defining first and second lead bore cavities sized for receiving terminal pins of leads, first and second labels, and an outer layer. The first label is printed onto a surface of the core assembly proximate the first lead bore cavity and includes a first color. The second label is printed onto the surface of the core assembly proximate the second lead bore cavity and includes a second color different from the first color. The outer layer is overmolded over the core assembly so as to encapsulate the first and second labels and to allow access to the first and second lead bore cavities.

Abstract: A fiber optic directional sensor has a substantially hemispherical dome surface and a substantially flat surface. The sensor is formed from a plurality of optical fibers fused to one another, and each optical fiber extends from the dome surface to the flat surface. One end of each optical fiber is substantially perpendicular to the sensor's dome surface, and the opposite end of the fiber is substantially perpendicular to the sensor's flat surface such that an end face of the fiber is substantially tangent to the dome surface, and another end face of the fiber is substantially tangent to the flat surface. The sensor further includes an optical element which expands the field of view of the sensor and chromatically controls the incoming light. Using the sensor, light from projectiles, such as missiles, bullets, and other weaponry, can be detected, and the locations of the projectiles can be determined.

Abstract: An implantable pulse generator includes a device housing containing pulse generator circuitry and a header connected to the device housing. The header includes a core assembly defining first and second lead bore cavities sized for receiving terminal pins of leads, first and second labels, and an outer layer. The first label is printed onto a surface of the core assembly proximate the first lead bore cavity and includes a first color. The second label is printed onto the surface of the core assembly proximate the second lead bore cavity and includes a second color different from the first color. The outer layer is overmolded over the core assembly so as to encapsulate the first and second labels and to allow access to the first and second lead bore cavities.

Abstract: A 3 by 2 tabloid printing press includes a plate cylinder having a straight across lock-up and a blanket cylinder contacting the plate cylinder; a blanket cylinder printing a web; and a folder superstructure having at least one slitter for slitting the web into three ribbons and a folder for forming a tabloid newspaper from the three ribbons.

Abstract: The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.

Abstract: An image capture system comprises a plurality of cameras and a camera mount. The camera mount has a curved portion, and the plurality of cameras are secured to the curved portion. The cameras are oriented radially inward relative to the curved portion of the camera mount, such that the lines of sight of the cameras intersect. Images are captured substantially simultaneously with the plurality of cameras. The captured images are stitched together to form a collective image. The image capture system may be positioned in an aerial vehicle to provide overhead views of an environment, and captured images may be transmitted to a remote location for viewing in substantially real time. A remote user may indicate a region of interest within the collective image, and the image capture system may render a portion of the collective image in accordance with the user's indications.

Abstract: The present invention generally relates to processes and methods for the capture of carbon dioxide from gases that are produced by various industrial processes including the capture of CO2 from flue gases after the combustion of carbon-based fuels.

Abstract: The present invention generally relates to carbonic anhydrase xerogel particles comprising a polysilicate-polysilicone copolymer and carbonic anhydrase. The carbonic anhydrase xerogel particles can be used for carbon dioxide capture.

Abstract: An implantable pulse generator includes a device housing containing pulse generator circuitry and a header connected to the device housing. The header includes a core assembly defining first and second lead bore cavities sized for receiving terminal pins of leads, first and second labels, and an outer layer. The first label is printed onto a surface of the core assembly proximate the first lead bore cavity and includes a first color. The second label is printed onto the surface of the core assembly proximate the second lead bore cavity and includes a second color different from the first color. The outer layer is overmolded over the core assembly so as to encapsulate the first and second labels and to allow access to the first and second lead bore cavities.

Abstract: The present invention generally relates to immobilized biocatalysts or immobilized enzymes for use in carbon capture and sequestration technology. Thiol-ene chemistry is used to couple a biocatalyst, particularly carbonic anhydrase, to a substrate including a substrate, a solid support, a microparticle, a nanoparticle, or a combination thereof.

Abstract: The present invention generally relates to immobilized biocatalysts or immobilized enzymes for use in carbon capture and sequestration technology. Thiol-ene chemistry is used to couple a biocatalyst, particularly carbonic anhydrase, to a substrate including a substrate, a solid support, a microparticle, a nanoparticle, or a combination thereof.

Abstract: A 3 by 2 tabloid printing press includes a plate cylinder having a straight across lock-up and a blanket cylinder contacting the plate cylinder; a blanket cylinder printing a web; and a folder superstructure having at least one slitter for slitting the web into three ribbons and a folder for forming a tabloid newspaper from the three ribbons.