Patents by Inventor John Rippeth
John Rippeth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230257692Abstract: The present invention features filtration assemblies, cassettes, systems, and methods for filtering cells from a sample solution and then incubating the captured cells.Type: ApplicationFiled: July 8, 2021Publication date: August 17, 2023Inventors: John RIPPETH, Max WEHEBRINK, Frank TYLDESLEY, Richard SMITH
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Publication number: 20230131415Abstract: The present invention features microbiological nutrient media capable of supporting growth of microorganisms. The medium includes a gelling agent and a dye and/or pigment that reduces background.Type: ApplicationFiled: April 15, 2021Publication date: April 27, 2023Inventors: Jessica Tse BARRA, Juan Pablo RODRIGUEZ SANTANA, Tammy Bohannon GRABAR, John RIPPETH, Michael NOBLE, Gwilym HUGHES
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Patent number: 10605758Abstract: A method and device are provided for measuring a level of a clinically relevant analyte (such as glucose) in a fluid (such as blood). The device includes a flow path for conducting said fluid through the device; a detection chamber arranged on said flow path; and detector means arranged to detect analyte levels in the fluid in said chamber, wherein: said detection chamber contains a predetermined amount of an analyte such that that analyte mixes with fluid in the detection chamber to form, at the detector means, a calibration sample of the fluid at a time after the arrival of the fluid in said detection chamber, and said detector means is arranged to detect a first analyte level of an unadulterated sample of the fluid at a first time which is before the formation of said calibration sample and to detect a second analyte level of said calibration sample at a second time which is after the formation of said calibration sample.Type: GrantFiled: May 10, 2016Date of Patent: March 31, 2020Assignee: PA Knowledge LimitedInventors: Michael Noble, Craig Nelson, Mark Humphries, Carys Lloyd, David Edington, John Rippeth
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Patent number: 10222379Abstract: The present invention provides a flexible format for diagnostic tests that is applicable to measuring a wide range of properties of fluids, particularly physiological fluids, by creating a concentration gradient of an indicator in the sample under analysis and measuring a flux of the indicator through the sample which is used to determine a property of the sample. Aspects of the invention include a method of testing a property of a physiological fluid in a portable test device, a portable test device and a kit including a portable test device and a processor.Type: GrantFiled: September 10, 2013Date of Patent: March 5, 2019Assignee: PA KNOWLEDGE LIMITEDInventors: Michael Noble, Simon Kew, David Edington, John Rippeth, Mark Humphries
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Publication number: 20160252477Abstract: A method and device are provided for measuring a level of a clinically relevant analyte (such as glucose) in a fluid (such as blood). The device includes a flow path for conducting said fluid through the device; a detection chamber arranged on said flow path; and detector means arranged to detect analyte levels in the fluid in said chamber, wherein: said detection chamber contains a predetermined amount of an analyte such that that analyte mixes with fluid in the detection chamber to form, at the detector means, a calibration sample of the fluid at a time after the arrival of the fluid in said detection chamber, and said detector means is arranged to detect a first analyte level of an unadulterated sample of the fluid at a first time which is before the formation of said calibration sample and to detect a second analyte level of said calibration sample at a second time which is after the formation of said calibration sample.Type: ApplicationFiled: May 10, 2016Publication date: September 1, 2016Inventors: Michael NOBLE, Craig NELSON, Mark HUMPHRIES, Carys LLOYD, David EDINGTON, John RIPPETH
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Publication number: 20150247862Abstract: The present invention provides a flexible format for diagnostic tests that is applicable to measuring a wide range of properties of fluids, particularly physiological fluids, by creating a concentration gradient of an indicator in the sample under analysis and measuring a flux of the indicator through the sample which is used to determine a property of the sample. Aspects of the invention include a method of testing a property of a physiological fluid in a portable test device, a portable test device and a kit including a portable test device and a processor.Type: ApplicationFiled: September 10, 2013Publication date: September 3, 2015Inventors: Michael Noble, Simon Kew, David Edington, John Rippeth, Mark Humphries
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Publication number: 20130112573Abstract: A method and device are provided for measuring a level of a clinically relevant analyte (such as glucose) in a fluid (such as blood). The device includes a flow path for conducting said fluid through the device; a detection chamber arranged on said flow path; and detector means arranged to detect analyte levels in the fluid in said chamber, wherein: said detection chamber contains a predetermined amount of an analyte such that that analyte mixes with fluid in the detection chamber to form, at the detector means, a calibration sample of the fluid at a time after the arrival of the fluid in said detection chamber, and said detector means is arranged to detect a first analyte level of an unadulterated sample of the fluid at a first time which is before the formation of said calibration sample and to detect a second analyte level of said calibration sample at a second time which is after the formation of said calibration sample.Type: ApplicationFiled: May 6, 2011Publication date: May 9, 2013Applicant: Exacsys LimitedInventors: Michael Noble, Craig Nelson, Mark Humphries, Carys Lloyd, David Edington, John Rippeth
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Patent number: 7250095Abstract: A non-mediated enzyme electrode comprises a base substrate (2) on which is provided an electrically conductive base layer (8) comprising finely divided platinum group metal or oxide bonded together by a resin; a top layer on the base layer (8), the top layer comprising a buffer. A catalytically active quantity of an oxidoreductase enzyme is provided in at least one of the base layer and the top layer. The invention also provides a biosensor (20) which includes an enzyme electrode, and methods of manufacturing the enzyme electrode and biosensor.Type: GrantFiled: July 10, 2003Date of Patent: July 31, 2007Assignee: Hypoguard LimitedInventors: Murdo M. Black, Colin Butters, Wah O. Ho, John Rippeth
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Publication number: 20070017824Abstract: A biosensor (12) includes a working electrode (5) and a counter electrode (3), wherein at least a part of the working electrode (5) is disposed between and in electrical connection with two separate conductive tracks (1,2). Other aspects of the invention provide a meter (26) for use with the biosensor (12) and a method of determining whether a fluid sample applied to the biosensor (12) has sufficiently wetted the working electrode (5).Type: ApplicationFiled: July 18, 2006Publication date: January 25, 2007Inventors: John Rippeth, Wah Ho
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Publication number: 20070000777Abstract: A test system for measuring analyte concentration in a fluid sample includes: (i) a capillary-fill biosensor (20) having a working electrode (24), a reference electrode (22) and a separate counter electrode (23), arranged such that a fluid sample which flows evenly along the capillary flow path will substantially completely cover the reference electrode (22) before the fluid sample makes contact with any part of the counter electrode (23); and (ii) a test meter (42) for receiving the biosensor (20), the meter (42) including: first signal circuitry (31) for producing a first signal when an electrical circuit is detected between the reference electrode (22) and the working electrode (24); second signal circuitry (33) for producing a second signal when an electrical circuit is detected between the counter electrode (23) and at least one of the reference electrode (22) and the working electrode (24); a timer (35) for determining the time interval between production of said first signal and said second signType: ApplicationFiled: June 1, 2006Publication date: January 4, 2007Inventors: Wah Ho, John Rippeth, Paul Chambers
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Publication number: 20050150763Abstract: A non-mediated biosensor for indicating amperometrically the catalytic activity of an oxidoreductase enzyme in the presence of a fluid containing a substance acted upon by said enzyme, the biosensor comprising: (a) a first substrate; (b) a working electrode and a counter electrode on the first substrate; (c) conductive tracks connected to said electrodes for making electrical connections with a test meter apparatus; (d) a second substrate overlying at least a part of the first substrate; and (e) a spacer layer having a channel therein and disposed between the first substrate and the second substrate, the spacer layer channel co-operating with adjacent surfaces to define a capillary flow path which does not contain a mesh and which extends from an edge of at least one of said substrates to said electrodes; wherein the working electrode includes: (f) an electrically-conductive base layer comprising particles of finely divided platinum-group metal or platinum-group metal oxide bonded together by a resin; (g) a tType: ApplicationFiled: January 4, 2005Publication date: July 14, 2005Inventors: Colin Butters, Wah Ho, Christopher Mayne, John Rippeth
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Publication number: 20050150762Abstract: A biosensor (20) for indicating electrochemically the catalytic activity of an enzyme in the presence of a biological fluid containing an analyte acted upon by said enzyme comprises: (a) a first substrate (2); (b) a second substrate (18) overlying at least a part of the first substrate (2); (c) a working electrode (24) on one of the substrates, the working electrode (24) including a catalytically-active quantity of said enzyme; (d) a counter electrode (22) on one of the substrates; (e) conductive tracks (4, 6) connected to said working (24) and counter (22) electrodes for making electrical connections with a test meter apparatus; (f) a spacer layer (14) having a channel (16) therein and disposed between the first substrate (2) and the second substrate (18), the spacer layer channel (16) co-operating with adjacent surfaces to define a capillary flow path which extends from an edge of at least one of said substrates (2, 18) to said electrodes (22, 24); wherein the electrodes (22, 24) are arranged suchType: ApplicationFiled: January 4, 2005Publication date: July 14, 2005Inventors: Colin Butters, Wah Ho, John Rippeth
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Publication number: 20040061841Abstract: A non-mediated enzyme electrode comprises a base substrate (2) on which is provided an electrically conductive base layer (8) comprising finely divided platinum group metal or oxide bonded together by a resin; a top layer on the base layer (8), the top layer comprising a buffer. A catalytically active quantity of an oxidoreductase enzyme is provided in at least one of the base layer and the top layer. The invention also provides a biosensor (20) which includes an enzyme electrode, and methods of manufacturing the enzyme electrode and biosensor.Type: ApplicationFiled: July 10, 2003Publication date: April 1, 2004Inventors: Murdo M. Black, Colin Butters, Wah O. Ho, John Rippeth