Abstract: A machine learning algorithm is trained on a number of microscopic images and a measure of outcome of each image. Each image is divided into tiles. The measure of outcome is assigned to each tile of the image. The tiles are then used to train the machine learning algorithm. The trained algorithm may then be used to evaluate images.

Abstract: A machine learning algorithm is trained on a number of microscopic images and a measure of outcome of each image. Each image is divided into tiles. The measure of outcome is assigned to each tile of the image. The tiles are then used to train the machine learning algorithm. The trained algorithm may then be used to evaluate images.

Abstract: The present invention relates to a system that can be used to accurately classify objects in biological specimens. The user firstly classifies manually an initial set of images, which are used to train a classifier. The classifier then is run on a complete set of images, and outputs not merely the classification but the probability that each image is in a variety of classes. Images are then displayed, sorted not merely by the proposed class but also the likelihood that the image in fact belongs in a proposed alternative class. The user can then reclassify images as required.

Abstract: An apparatus and computer-implemented method for training a machine-learning algorithm to perform histopathological analysis is disclosed. The method comprises obtaining (210) a plurality of first microscopic images of first histological specimens that have been stained with a first marker; and obtaining (212), a respective plurality of second microscopic images of second histological specimens that have been stained with a second, different marker. The method further comprises obtaining (220) a respective plurality of mask images generated for the second microscopic images, each mask image identifying a histological feature of interest highlighted in the respective second microscopic image by the second marker. The method comprises training (240) the machine-learning algorithm to predict, from a first microscopic image, a histological feature of interest that would be highlighted in the same specimen by the second marker.

Abstract: A machine learning algorithm is trained on a number of microscopic images and a measure of outcome of each image. Each image is divided into tiles. The measure of outcome is assigned to each tile of the image. The tiles are then used to train the machine learning algorithm. The trained algorithm may then be used to evaluate images.

Abstract: An apparatus and computer-implemented method for training a machine-learning algorithm to perform histopathological analysis is disclosed. The method comprises obtaining (210) a plurality of first microscopic images of first histological specimens that have been stained with a first marker; and obtaining (212), a respective plurality of second microscopic images of second histological specimens that have been stained with a second, different marker. The method further comprises obtaining (220) a respective plurality of mask images generated for the second microscopic images, each mask image identifying a histological feature of interest highlighted in the respective second microscopic image by the second marker. The method comprises training (240) the machine-learning algorithm to predict, from a first microscopic image, a histological feature of interest that would be highlighted in the same specimen by the second marker.

Abstract: A method of image classification is used for classifying images of stained cell nuclei. For each nucleus, the total integrated optical density is calculated and a histogram calculated. The image is then classified by automatically identifying peaks, identifying the lowest peak as a 2C peak and classifying the image as at least one of diploid, tetraploid, aneuploid or polyploid based on the number of peaks and the count at an integrated optical densities above the 2C peak.

Abstract: A method of image classification is used for classifying images of stained cell nuclei. For each nucleus, the total integrated optical density is calculated and a histogram calculated. The image is then classified by automatically identifying peaks, identifying the lowest peak as a 2C peak and classifying the image as at least one of diploid, tetraploid, aneuploid or polyploid based on the number of peaks and the count at an integrated optical densities above the 2C peak.